Radiation-associated angiosarcoma of the breast: An international multicenter analysis
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, multicentrická studie
PubMed
35203019
DOI
10.1016/j.suronc.2022.101726
PII: S0960-7404(22)00019-6
Knihovny.cz E-zdroje
- Klíčová slova
- Angiosarcoma, Breast, Multicenter study, Radiation,
- MeSH
- adjuvantní radioterapie * škodlivé účinky MeSH
- dospělí MeSH
- hemangiosarkom * radioterapie MeSH
- lidé středního věku MeSH
- lidé MeSH
- lokální recidiva nádoru MeSH
- mastektomie MeSH
- nádory prsu * radioterapie MeSH
- nádory vyvolané zářením * epidemiologie MeSH
- následné studie MeSH
- retrospektivní studie MeSH
- segmentální mastektomie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
INTRODUCTION: Radiation-associated angiosarcoma (RAAS) is a rare and serious complication of breast irradiation. Due to the rarity of the condition, clinical experience is limited and publications on this topic include only retrospective studies or case reports. MATERIALS AND METHODS: All patients diagnosed with RAAS between January 2000 and December 2017 in twelve centers across the Czech Republic and Slovakia were evaluated. RESULTS: Data of 53 patients were analyzed. The median age at diagnosis was 72 (range 44-89) years. The median latency period between irradiation and diagnosis of RAAS was 78 (range 36-172) months. The median radiation dose was 57.6 (range 34-66) Gy. The whole breast radiation therapy with radiation boost to the tumor bed was the most common radiotherapy regimen. Total mastectomy due to RAAS was performed in 43 patients (81%), radical excision in 8 (15%); 2 patients were not surgically treated due to unresectable disease. Adjuvant chemotherapy followed surgical therapy of RAAS in 18 patients, 3 patients underwent adjuvant radiotherapy. The local recurrence rate of RAAS was 43% and the median time from surgery to the onset of recurrence was 7.5 months (range 3-66 months). The 3-year survival rate was 56%, the 5-year survival rate was only 33%. 46% of patients died during the follow-up period. CONCLUSION: The present data demonstrate that RAAS is a rare condition with high local recurrence rate (43%) and mortality (the 5-year survival rate was 33%.). Early diagnosis of RAAS based on biopsy is crucial for treatment with radical intent. Surgery with negative margins constitutes the most important part of the therapy; the role of adjuvant chemotherapy and radiotherapy is still unclear.
1th Surgical Department General University Hospital Prague Prague Czech Republic
Department of Oncology and Radiotherapy University Hospital Pilsen Pilsen Czech Republic
Department of Oncology EUC Clinic Zlín Zlín Czech Republic
Department of Oncology Pardubice General Hospital Pardubice Czech Republic
Department of Pathology Liberec General Hospital Liberec Czech Republic
Department of Pathology Pardubice General Hospital Pardubice Czech Republic
Department of Pathology St Elizabeth Cancer Institute Bratislava Slovak Republic
Department of Radiation and Clinical Oncology Liberec General Hospital Liberec Czech Republic
Department of Radiooncology St Elizabeth Cancer Institute Bratislava Slovak Republic
Department of Surgery EUC Clinic Zlín Zlín Czech Republic
Department of Surgery Hospital AGEL Ostrava Vítkovice Ostrava Czech Republic
Department of Surgery Liberec General Hospital Liberec Czech Republic
Department of Surgery Pardubice General Hospital Pardubice Czech Republic
Department of Surgery University Hospital Ostrava Ostrava Czech Republic
Department of Surgery University Hospital Pilsen Pilsen Czech Republic
Department of Surgical Oncology St Elizabeth Cancer Institute Bratislava Slovak Republic
Citace poskytuje Crossref.org
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