Metabolic tricks of cancer cells
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, přehledy, práce podpořená grantem
PubMed
35276232
DOI
10.1016/j.bbcan.2022.188705
PII: S0304-419X(22)00030-0
Knihovny.cz E-zdroje
- Klíčová slova
- Cancer metabolism, Cell death, Glutaminolysis, Metabolic symbiosis, Mitochondrial bioenergetics, Warburg effect,
- MeSH
- energetický metabolismus MeSH
- lidé MeSH
- metabolické sítě a dráhy MeSH
- nádorová transformace buněk metabolismus MeSH
- nádorové mikroprostředí * MeSH
- nádory * patologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
One of the characteristics of cancer cells important for tumorigenesis is their metabolic plasticity. Indeed, in various stress conditions, cancer cells can reshape their metabolic pathways to support the increased energy request due to continuous growth and rapid proliferation. Moreover, selective pressures in the tumor microenvironment, such as hypoxia, acidosis, and competition for resources, force cancer cells to adapt by complete reorganization of their metabolism. In this review, we highlight the characteristics of cancer metabolism and discuss its clinical significance, since overcoming metabolic plasticity of cancer cells is a key objective of modern cancer therapeutics and a better understanding of metabolic reprogramming may lead to the identification of possible targets for cancer therapy.
Citace poskytuje Crossref.org
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