Metabolic tricks of cancer cells
Language English Country Netherlands Media print-electronic
Document type Journal Article, Review, Research Support, Non-U.S. Gov't
PubMed
35276232
DOI
10.1016/j.bbcan.2022.188705
PII: S0304-419X(22)00030-0
Knihovny.cz E-resources
- Keywords
- Cancer metabolism, Cell death, Glutaminolysis, Metabolic symbiosis, Mitochondrial bioenergetics, Warburg effect,
- MeSH
- Energy Metabolism MeSH
- Humans MeSH
- Metabolic Networks and Pathways MeSH
- Cell Transformation, Neoplastic metabolism MeSH
- Tumor Microenvironment * MeSH
- Neoplasms * pathology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
One of the characteristics of cancer cells important for tumorigenesis is their metabolic plasticity. Indeed, in various stress conditions, cancer cells can reshape their metabolic pathways to support the increased energy request due to continuous growth and rapid proliferation. Moreover, selective pressures in the tumor microenvironment, such as hypoxia, acidosis, and competition for resources, force cancer cells to adapt by complete reorganization of their metabolism. In this review, we highlight the characteristics of cancer metabolism and discuss its clinical significance, since overcoming metabolic plasticity of cancer cells is a key objective of modern cancer therapeutics and a better understanding of metabolic reprogramming may lead to the identification of possible targets for cancer therapy.
References provided by Crossref.org
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