Infections are a growing global threat, and the number of resistant species of microbial pathogens is alarming. However, the rapid development of cross-resistant or multidrug-resistant strains and the development of so-called 'superbugs' are in stark contrast to the number of newly launched anti-infectives on the market. In this review, I summarize the causes of antimicrobial resistance, briefly discuss different approaches to the discovery and development of new anti-infective drugs, and focus on drug repurposing strategy, which is discussed from all possible perspectives. A comprehensive overview of drugs of other indications tested for their in vitro antimicrobial activity to support existing anti-infective therapeutics is provided, including several critical remarks on this strategy of repurposing non-antibiotics to antibacterial drugs.

Department of Analytical Chemistry Faculty of Natural Sciences Comenius University Ilkovicova 6 842 15 Bratislava Slovakia; Department of Chemical Biology Faculty of Science Palacky University Slechtitelu 27 783 71 Olomouc Czech Republic

Citace poskytuje Crossref.org

Design, Synthesis and Antimicrobial Properties of New Tetracyclic Quinobenzothiazine Derivatives

Trifluoromethylcinnamanilide Michael Acceptors for Treatment of Resistant Bacterial Infections

Anticancer Applications of Essential Oils Formulated into Lipid-Based Delivery Nanosystems

Study of Biological Activities and ADMET-Related Properties of Salicylanilide-Based Peptidomimetics