We report a protocol for the one-pot two-step synthesis of noradamantane methylene amines. The first step is the triflic acid-promoted decarboxylation of adamantane carbamates, which causes rearrangement of the adamantane framework to form noradamantane iminium salts, which are reduced to amines in the second separate step.

Charles University Faculty of Science Department of Inorganic Chemistry Hlavova 8 12840 Praha Czech Republic

Charles University Faculty of Science Department of Organic Chemistry Hlavova 8 12840 Praha Czech Republic

University of Pardubice Faculty of Chemical Technology Studentská 573 53210 Pardubice Czech Republic

Uzhhorod National University Narodna Ploshcha 3 88000 Uzhhorod Ukraine

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Synthesis of 1,2-Disubstituted Adamantane Derivatives by Construction of the Adamantane Framework