Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu metaanalýza, časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem
Grantová podpora
R01 MH118695
NIMH NIH HHS - United States
R01 NS114628
NINDS NIH HHS - United States
R21 MH097196
NIMH NIH HHS - United States
R01 EB015611
NIBIB NIH HHS - United States
RF1 NS114628
NINDS NIH HHS - United States
R01 MH116147
NIMH NIH HHS - United States
RF1 MH123163
NIMH NIH HHS - United States
U24 RR021992
NCRR NIH HHS - United States
R01 MH121246
NIMH NIH HHS - United States
U24 RR025736
NCRR NIH HHS - United States
R01 AG059874
NIA NIH HHS - United States
R01 MH083968
NIMH NIH HHS - United States
R01 MH121101
NIMH NIH HHS - United States
MR/R024790/1
Medical Research Council - United Kingdom
U54 EB020403
NIBIB NIH HHS - United States
R01 MH117601
NIMH NIH HHS - United States
MR/R024790/2
Medical Research Council - United Kingdom
S10 OD023696
NIH HHS - United States
PubMed
36494461
PubMed Central
PMC10005935
DOI
10.1038/s41380-022-01897-w
PII: 10.1038/s41380-022-01897-w
Knihovny.cz E-zdroje
- MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- magnetická rezonanční tomografie MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mozek patologie MeSH
- prospektivní studie MeSH
- schizofrenie * MeSH
- senioři MeSH
- stárnutí MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- metaanalýza MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
Schizophrenia (SZ) is associated with an increased risk of life-long cognitive impairments, age-related chronic disease, and premature mortality. We investigated evidence for advanced brain ageing in adult SZ patients, and whether this was associated with clinical characteristics in a prospective meta-analytic study conducted by the ENIGMA Schizophrenia Working Group. The study included data from 26 cohorts worldwide, with a total of 2803 SZ patients (mean age 34.2 years; range 18-72 years; 67% male) and 2598 healthy controls (mean age 33.8 years, range 18-73 years, 55% male). Brain-predicted age was individually estimated using a model trained on independent data based on 68 measures of cortical thickness and surface area, 7 subcortical volumes, lateral ventricular volumes and total intracranial volume, all derived from T1-weighted brain magnetic resonance imaging (MRI) scans. Deviations from a healthy brain ageing trajectory were assessed by the difference between brain-predicted age and chronological age (brain-predicted age difference [brain-PAD]). On average, SZ patients showed a higher brain-PAD of +3.55 years (95% CI: 2.91, 4.19; I2 = 57.53%) compared to controls, after adjusting for age, sex and site (Cohen's d = 0.48). Among SZ patients, brain-PAD was not associated with specific clinical characteristics (age of onset, duration of illness, symptom severity, or antipsychotic use and dose). This large-scale collaborative study suggests advanced structural brain ageing in SZ. Longitudinal studies of SZ and a range of mental and somatic health outcomes will help to further evaluate the clinical implications of increased brain-PAD and its ability to be influenced by interventions.
3rd Faculty of Medicine Charles University Prague Czech Republic
Advanced Computation and e Science Instituto de Física de Cantabria CSIC Santander Spain
Campbell Family Mental Health Research Institute CAMH Toronto Canada
Center for the Neurobiology of Learning and Memory University of California Irvine CA USA
Centre for Youth Mental Health The University of Melbourne Melbourne VIC Australia
Centro de Investigación Biomédica en Red de Salud Mental Instituto de Salud Carlos 3 Spain
Dementia Research Centre Queen Square Institute of Neurology University College London London UK
Department of Computer Science Georgia State University Atlanta GA USA
Department of Experimental Psychopathology and Psychotherapy University of Zurich Zurich Switzerland
Department of Neuropsychiatry Seoul National University Hospital Seoul South Korea
Department of Neuroscience and Physiology SUNY Upstate Medical University Syracuse NY USA
Department of Psychiatry and Behavioral Sciences Baylor College of Medicine Houston TX USA
Department of Psychiatry and Human Behavior University of California Irvine CA USA
Department of Psychiatry and Neuropsychology Maastricht University Maastricht The Netherlands
Department of Psychiatry and Psychotherapy Ludwig Maximilians Universität Munich Munich Germany
Department of Psychiatry Jeonbuk National University Hospital Jeonju Korea
Department of Psychiatry Jeonbuk National University Medical School Jeonju Korea
Department of Psychiatry Monash University Clayton VIC Australia
Department of Psychiatry Psychiatric University Hospital University of Basel Basel Switzerland
Department of Psychiatry Psychosomatics and Psychotherapy University of Lübeck Lübeck Germany
Department of Psychiatry Seoul National University College of Medicine Seoul South Korea
Department of Psychiatry Stellenbosch University Cape Town South Africa
Department of Psychiatry University of Basel Basel Switzerland
Department of Psychiatry University of California San Diego San Diego CA USA
Department of Psychiatry University of New Mexico Albuquerque NM USA
Department of Psychiatry University of Toronto Toronto ON Canada
Department of Psychology Georgia State University Atlanta GA USA
Department of Psychology School of Arts and Social Sciences City University of London London UK
Department of Psychology School of Business National College of Ireland Dublin Ireland
Department of Psychology University of Bath Bath UK
Department of Translational Biomedicine and Neuroscience University of Bari Aldo Moro Bari Italy
Division of Addiction Medicine Centre Hospitalier des Quatre Villes St Cloud France
Division of Adult Psychiatry Department of Psychiatry Geneva University Hospitals Geneva Switzerland
Faculty of Electrical Engineering Czech Technical University Prague Prague Czech Republic
FIDMAG Germanes Hospitalàries Research Foundation Barcelona Catalonia Spain
Florey Institute of Neuroscience and Mental Health Parkville VIC Australia
Hospital Benito Menni CASM Sant Boi de Llobregat Catalonia Spain
Hospital Universitario Virgen del Rocío IBiS CSIC Universidad de Sevilla Seville Spain
Hunter Medical Research Institute Newcastle NSW Australia
Institute for Translational Psychiatry University of Münster Münster Germany
Institute of Computer Science Czech Academy of Sciences Prague Czech Republic
Laboratory of Neuropsychiatry IRCCS Santa Lucia Foundation Rome Italy
Lee Kong Chian School of Medicine Nanyang Technological University Singapore Singapore
Mental Health Research Center Moscow Russia
National Institute of Mental Health Klecany Czech Republic
Neuroscience Institute Georgia State University Atlanta GA USA
Neuroscience Research Australia Sydney NSW Australia
Orygen Parkville VIC Australia
Priority Research Centre for Health Behaviour The University of Newcastle Newcastle NSW Australia
Psychiatric University Hospital Zurich Zurich Switzerland
Queensland Brain Institute The University of Queensland Brisbane QLD Australia
School of Biomedical Sciences and Pharmacy University of Newcastle Newcastle NSW Australia
School of Medicine and Public Health The University of Newcastle Newcastle NSW Australia
School of Medicine University of Queensland Herston QLD Australia
School of Psychiatry University of New South Wales Sydney NSW Australia
School of Psychological Sciences University of Newcastle Callaghan NSW Australia
School of Psychology University of New South Wales Sydney NSW Australia
The Queensland Centre for Mental Health Research The University of Queensland Brisbane QLD Australia
West Region Institute of Mental Health Singapore Singapore
Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore
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