BACKGROUND: Physical inactivity and unhealthy dietary habits are known to be disadvantageous for the development of late adverse effects in survivors of childhood, adolescent, and young adult cancer. To make interventions, aimed at improving lifestyle, fit into the daily life of survivors, interventions should be designed and delivered in a person-centred way with a limited time burden. As part of the European PanCareFollowUp project, an eHealth intervention was developed to support sustainable changes to physical activity levels and/or diet of childhood, adolescent, and young adult cancer survivors. This feasibility study aims to gain insight into the feasibility and potential effect sizes of the PanCareFollowUp lifestyle intervention. METHODS: The PanCareFollowUp lifestyle intervention consists of person-centred 3-6 screen-to-screen sessions with a certified lifestyle coach. The intervention will be evaluated with a single-arm pre-post feasibility study conducted at two survivorship care clinics in the Netherlands. A total of 60 participants who are (i) diagnosed with cancer <25 years, (ii) ≥ 5 years post-treatment, (iii) aged 16-55 years, and (iv) have a low physical activity level and/or unhealthy dietary intake manifested by overweight will be recruited. Using reports, hospital records, and questionnaires for survivors, coaches, and late effect doctors, feasibility will be based on (i) adherence to intervention, (ii) acceptability, (iii) practicality, (iv) integration/implementation, (v) demand, and (vi) attrition. The potential effect sizes of the intervention will be explored by determining the percentage of survivors that reach the personalized lifestyle goals that were set with the coach. Physical activity level, dietary intake, BMI, general self-efficacy, self-management, and motivation level will be assessed at three time points with questionnaires, reports, and/or an accelerometer. DISCUSSION: Data of this study will be gathered to assess the feasibility and potential effect sizes. This will allow for further intervention refinement as needed as well as to inform a future large-scale intervention study and a manual for implementation at other centres. TRIAL REGISTRATION: International Clinical Trial Registry Platform (ICTRP) number: NL8932 (ICTRP Search Portal (who.int)). Registered on September 29, 2020.

Centre of Expertise for Cancer Survivorship Radboud Institute for Health Sciences Radboud University Medical Centre Reinier Postlaan 4 6500 HB Nijmegen the Netherlands

Department of Haematology Radboud University Medical Centre Radboud Institute for Health Sciences Geert Grooteplein Zuid 10 6525 GA Nijmegen Nederland

Department of Health Technology and Services Research Technical Medical Centre University of Twente P O Box 217 7500 AE Enschede the Netherlands

Department of Paediatrics Emma Children's Hospital Amsterdam UMC Meibergdreef 9 1105 AZ Amsterdam the Netherlands

Faculty of Medicine Utrecht University and Utrecht Medical Centre Universiteitsweg 98 3584 CG Utrecht the Netherlands

Great North Children's Hospital Royal Victoria Infirmary Queen Victoria Road Newcastle upon Tyne NE1 4LP UK

International Clinical Research Centre St Anne's University Hospital Masaryk University Pekařská 53 656 91 Brno Czech Republic

PanCare Jacobus Bellamylaan 16 1401 AZ Bussum the Netherlands

Population Health Sciences Institute Newcastle University Ridley Building 1 Queen Victoria Road Newcastle upon Tyne NE1 7RU4 UK

Princess Máxima Centre for Paediatric Oncology Heidelberglaan 25 3584 CS Utrecht the Netherlands

Scientific Institute for Quality of Healthcare Radboud Institute for Health Sciences Radboud University Medical Centre Geert Grooteplein Zuid 10 6525 GA Nijmegen the Netherlands

Translational and Clinical Research Institute Wolfson Childhood Cancer Research Centre Herschel Building Brewery Lane Newcastle upon Tyne NE1 7RU UK

Wolfson Childhood Cancer Research Centre Newcastle University Centre for Cancer Newcastle University Herschel Building Brewery Lane Newcastle upon Tyne NE1 7RU UK

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