Antiphospholipid antibody-mediated NK cell cytotoxicity
Language English Country Ireland Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
36621092
DOI
10.1016/j.jri.2022.103791
PII: S0165-0378(22)00320-5
Knihovny.cz E-resources
- Keywords
- Antiphospholipid antibodies, Antiphospholipid syndrome, Cytotoxicity, Degranulation, Hypoxia, Natural killer cells,
- MeSH
- Antibodies, Antiphospholipid * MeSH
- Antiphospholipid Syndrome * complications pathology MeSH
- beta 2-Glycoprotein I MeSH
- Killer Cells, Natural * metabolism MeSH
- Humans MeSH
- Pregnancy Trimester, First MeSH
- Pregnancy MeSH
- Check Tag
- Humans MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antibodies, Antiphospholipid * MeSH
- beta 2-Glycoprotein I MeSH
Antiphospholipid syndrome (APS) is an autoimmune thrombophilia that is characterised by thrombosis and obstetric complications in the presence of antiphospholipid antibodies (aPL). Pregnancy complications remain a challenging problem for patients with APS, especially during the first trimester. Although natural killer (NK) cells constitute up to 70% of decidual lymphocytes during the first trimester, their contribution to early pregnancy loss in APS is largely unknown. We aimed to analyse whether aPL are able to recruit antibody-dependent cellular cytotoxicity (ADCC) of NK cells, with special emphasis on the differences in the effects of aPL containing anti-β2GPI domain 1 (anti-β2GPI-D1) antibodies (aPL+/D1+) and those that do not (aPL+/D1-). Our findings revealed a differential distribution of NK subsets in the presence of different aPL. Namely, aPL+/D1- IgGs increased CD56dim/CD16dim cells, while aPL+/D1 + IgGs increased the number of CD56bright/CD16dim cells. ADCC NK cell cytotoxicity was found to be higher in the presence of aPL+/D1- IgGs, as defined by an increased target cell death, degranulation and increased expression of CD11b, CD69 and NKG2D. Overall, our evidence showed that aPL are able to recruit ADCC, suggesting NK cells as candidate cells for APS-related obstetric complications.
References provided by Crossref.org
NK cell dysfunction in antiphospholipid syndrome
