iGlarLixi (insulin glargine 100 U/ml plus lixisenatide) is effective and well tolerated in people with uncontrolled type 2 diabetes regardless of age: A REALI pooled analysis of prospective real-world data
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
36810874
DOI
10.1111/dom.15027
Knihovny.cz E-zdroje
- Klíčová slova
- age, elderly, fixed-ratio combination, iGlarLixi, insulin glargine, lixisenatide, real-world data, type 2 diabetes,
- MeSH
- diabetes mellitus 2. typu * komplikace farmakoterapie MeSH
- dospělí MeSH
- fixní kombinace léků MeSH
- glykovaný hemoglobin MeSH
- hypoglykemika škodlivé účinky MeSH
- inzulin glargin škodlivé účinky MeSH
- krevní glukóza MeSH
- lidé MeSH
- prospektivní studie MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- senioři MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- fixní kombinace léků MeSH
- glykovaný hemoglobin MeSH
- hypoglykemika MeSH
- inzulin glargin MeSH
- krevní glukóza MeSH
- lixisenatide MeSH Prohlížeč
AIM: To evaluate the effectiveness and safety in routine clinical practice of insulin glargine/lixisenatide (iGlarLixi) in people with type 2 diabetes (T2D) according to age. METHODS: Patient-level data were pooled from 1316 adults with T2D inadequately controlled on oral antidiabetic drugs with or without basal insulin who initiated iGlarLixi for 24 weeks. Participants were classified into age subgroups of younger than 65 years (N = 806) and 65 years or older (N = 510). RESULTS: Compared with participants aged younger than 65 years, those aged 65 years or older had a numerically lower mean body mass index (31.6 vs. 32.6 kg/m2 ), a longer median diabetes duration (11.0 vs. 8.0 years), were more likely to receive prior basal insulin (48.4% vs. 43.5%) and had a lower mean HbA1c (8.93% [74.10 mmol/mol] vs. 9.22% [77.28 mmol/mol]). Similar and clinically relevant reductions in HbA1c and fasting plasma glucose from baseline to week 24 of iGlarLixi therapy were observed regardless of age. At 24 weeks, least-squares adjusted mean (95% confidence interval [CI]) change in HbA1c from baseline was -1.55% (-1.65% to -1.44%) in those aged 65 years or older and -1.42% (-1.50% to -1.33%) in those aged younger than 65 years (95% CI: -0.26% to 0.00%; P = .058 between subgroups). Low incidences of gastrointestinal adverse events and hypoglycaemic episodes were reported in both age subgroups. iGlarLixi decreased mean body weight from baseline to week 24 in both subgroups (-1.6 kg in those aged ≥ 65 years and -2.0 kg in those aged < 65 years). CONCLUSIONS: iGlarLixi is effective and well tolerated in both younger and older people with uncontrolled T2D.
Department of Internal Medicine Centrum Szent János Hospital Budapest Hungary
General Medicines Sanofi Paris France
Institute for Clinical and Experimental Medicine and Charles University Prague Czech Republic
Institute of Clinical Trials and Methodology University College London London UK
International Drug Development Institute Louvain la Neuve Belgium
Zobrazit více v PubMed
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