STUDY OBJECTIVES: Social jetlag manifests as a difference in sleep timing on workdays and free days. Social jetlag is often associated with shorter, lower-quality sleep, so it is unclear how much the chronic circadian misalignment contributes to observed negative health outcomes. We aimed to (1) investigate associations between social jetlag, chronotype (one of its determinants), and the levels of health markers, (2) describe factors associated with social jetlag, and (3) examine whether working from home can reduce social jetlag. METHODS: Adult respondents participated in a nationally representative longitudinal survey of Czech households (individuals in each wave: n2018/19/20 = 5132/1957/1533), which included Munich ChronoType Questionnaire to evaluate chronotype and social jetlag. A subset provided blood samples (n2019 = 1957) for detection of nine biomarkers and was surveyed in three successive years (social jetlag calculated for n2018/19/20 = 3930/1601/1237). Data were analyzed by nonparametric univariate tests and mixed effects multivariate regression with social jetlag, chronotype, sex, age, body-mass index, and reported diseases as predictors and biomarker levels as outcomes. RESULTS: Higher social jetlag (≥0.65 h) was significantly associated with increased levels of total cholesterol and low-density lipoprotein cholesterol, particularly in participants older than 50 years (Mann-Whitney, men: pCHL = 0.0005, pLDL = 0.0009; women: pCHL = 0.0079, pLDL = 0.0068). Extreme chronotypes were associated with cardiovascular disease risk markers regardless of social jetlag (Kruskal-Wallis, p < 0.0001). Commuting to work and time stress were identified as important contributors to social jetlag. Individual longitudinal data showed that working from home decreased social jetlag and prolonged sleep. CONCLUSIONS: We report significant associations between sleep phase preference, social jetlag, and cardio-metabolic biomarkers.

Institute of Physiology The Czech Academy of Sciences Prague Czech Republic

Institute of Sociology The Czech Academy of Sciences Prague Czech Republic

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Sleep. 2023 Jun 13;46(6):zsad081. doi: 10.1093/sleep/zsad081. PubMed

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Panda S. Circadian physiology of metabolism. Science. 2016;354(6315):1008–1015. doi: 10.1126/science.aah4967 PubMed DOI PMC

Hastings MH, et al. . Generation of circadian rhythms in the suprachiasmatic nucleus. Nat Rev Neurosci. 2018;19(8):453–469. doi: 10.1038/s41583-018-0026-z PubMed DOI

Czeisler CA, et al. . Stability, precision, and near-24-hour period of the human circadian pacemaker. Science. 1999;284(5423):2177–2181. doi: 10.1126/science.284.5423.2177 PubMed DOI

Haus EL, et al. . Shift work and cancer risk: potential mechanistic roles of circadian disruption, light at night, and sleep deprivation. Sleep Med Rev. 2013;17(4):273–284. doi: 10.1016/j.smrv.2012.08.003 PubMed DOI

Morris CJ, et al. . Circadian misalignment increases cardiovascular disease risk factors in humans. Proc Natl Acad Sci U S A. 2016;113(10):E1402–E1411. doi: 10.1073/pnas.1516953113 PubMed DOI PMC

Walker WH, 2nd, et al. . Circadian rhythm disruption and mental health. Transl Psychiatry. 2020;10(1):28. doi: 10.1038/s41398-020-0694-0 PubMed DOI PMC

Horne JA, et al. . Individual differences in human circadian rhythms. Biol Psychol. 1977;5(3):179–190. doi: 10.1016/0301-0511(77)90001-1 PubMed DOI

Horne JA, et al. . A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. Int J Chronobiol. 1976;4(2):97–110. PubMed

Roenneberg T, et al. . Life between clocks: daily temporal patterns of human chronotypes. J Biol Rhythms. 2003;18(1):80–90. doi: 10.1177/0748730402239679 PubMed DOI

Roenneberg T, et al. . Chronotype and Social Jetlag: a (Self-) critical review. Biology. 2019;8(3). doi: 10.3390/biology8030054 PubMed DOI PMC

Pandi-Perumal SR, et al. . Dim light melatonin onset (DLMO): a tool for the analysis of circadian phase in human sleep and chronobiological disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31(1):1–11. doi: 10.1016/j.pnpbp.2006.06.020 PubMed DOI

Novakova M, et al. . Human chronotype is determined in bodily cells under real-life conditions. Chronobiol Int. 2013;30(4):607–617. doi: 10.3109/07420528.2012.754455 PubMed DOI

Levandovski R, et al. . Chronotype: a review of the advances, limits and applicability of the main instruments used in the literature to assess human phenotype. Trends Psychiatry Psychother. 2013;35:3–11. doi: 10.1590/s2237-60892013000100002 PubMed DOI

Antypa N, et al. . Chronotype associations with depression and anxiety disorders in a large cohort study. Depress Anxiety. 2016;33(1):75–83. doi: 10.1002/da.22422 PubMed DOI

Levandovski R, et al. . Depression scores associate with chronotype and social jetlag in a rural population. Chronobiol Int. 2011;28(9):771–778. doi: 10.3109/07420528.2011.602445 PubMed DOI

Baldanzi G, et al. . Evening chronotype is associated with elevated biomarkers of cardiometabolic risk in the EpiHealth cohort: a cross-sectional study. Sleep. 2022;45(2). doi: 10.1093/sleep/zsab226 PubMed DOI PMC

Kobayashi Frisk M, et al. . Eveningness is associated with sedentary behavior and increased 10-year risk of cardiovascular disease: the SCAPIS pilot cohort. Sci Rep. 2022;12(1):8203. doi: 10.1038/s41598-022-12267-5 PubMed DOI PMC

Vetter C. Circadian disruption: what do we actually mean? Eur J Neurosci. 2020;51(1):531–550. doi: 10.1111/ejn.14255 PubMed DOI PMC

Wittmann M, et al. . Social jetlag: misalignment of biological and social time. Chronobiol Int. 2006;23(1-2):497–509. doi: 10.1080/07420520500545979 PubMed DOI

Pallesen S, et al. . Prevalence of shift work disorder: a systematic review and meta-analysis. Front Psychol. 2021;12:638252. doi: 10.3389/fpsyg.2021.638252 PubMed DOI PMC

Roenneberg T, et al. . The Circadian clock and human health. Curr Biol. 2016;26(10):R432–R443. doi: 10.1016/j.cub.2016.04.011 PubMed DOI

Haynie DL, et al. . Beyond sleep duration: bidirectional associations among chronotype, social jetlag, and drinking behaviors in a longitudinal sample of US high school students. Sleep. 2018;41(2). doi: 10.1093/sleep/zsx202 PubMed DOI PMC

Haraszti RA, et al. . Social jetlag negatively correlates with academic performance in undergraduates. Chronobiol Int. 2014;31(5):603–612. doi: 10.3109/07420528.2013.879164 PubMed DOI

Rutters F, et al. . Is social jetlag associated with an adverse endocrine, behavioral, and cardiovascular risk profile? J Biol Rhythms. 2014;29(5):377–383. doi: 10.1177/0748730414550199 PubMed DOI

Roenneberg T, et al. . Social jetlag and obesity. Curr Biol. 2012;22(10):939–943. doi: 10.1016/j.cub.2012.03.038 PubMed DOI

Parsons MJ, et al. . Social jetlag, obesity and metabolic disorder: investigation in a cohort study. Int J Obes. 2015;39(5):842–848. doi: 10.1038/ijo.2014.201 PubMed DOI PMC

Caliandro R, et al. . Social jetlag and related risks for human health: a timely review. Nutrients. 2021;13(12):4543. doi: 10.3390/nu13124543 PubMed DOI PMC

Koopman ADM, et al. . The association between social jetlag, the metabolic syndrome, and type 2 diabetes mellitus in the general population: the new Hoorn study. J Biol Rhythms. 2017;32(4):359–368. doi: 10.1177/0748730417713572 PubMed DOI PMC

Islam Z, et al. . Association of social jetlag with metabolic syndrome among Japanese working population: the Furukawa Nutrition and Health Study. Sleep Med. 2018;51:53–58. doi: 10.1016/j.sleep.2018.07.003 PubMed DOI

Zuraikat FM, et al. . Sleep regularity and cardiometabolic heath: is variability in sleep patterns a risk factor for excess adiposity and glycemic dysregulation? Curr Diab Rep. 2020;20(8):38. doi: 10.1007/s11892-020-01324-w PubMed DOI PMC

Wong PM, et al. . Social jetlag, chronotype, and cardiometabolic risk. J Clin Endocrinol Metab. 2015;100(12):4612–4620. doi: 10.1210/jc.2015-2923 PubMed DOI PMC

Portaluppi F, et al. . Circadian rhythms and cardiovascular health. Sleep Med Rev. 2012;16(2):151–166. doi: 10.1016/j.smrv.2011.04.003 PubMed DOI

Sudy AR, et al. . Association of social jetlag with sleep quality and autonomic cardiac control during sleep in young healthy men. Front Neurosci. 2019;13:950. doi: 10.3389/fnins.2019.00950 PubMed DOI PMC

Islam Z, et al. . Social jetlag is associated with an increased likelihood of having depressive symptoms among the Japanese working population: the Furukawa Nutrition and Health Study. Sleep. 2020;43(1). doi: 10.1093/sleep/zsz204 PubMed DOI PMC

Foster RG, et al. . Sleep and circadian rhythm disruption in social jetlag and mental illness. Prog Mol Biol Transl Sci. 2013;119:325–346. doi: 10.1016/B978-0-12-396971-2.00011-7 PubMed DOI

Jankowski KS, et al. . Chronotype, social jetlag and sleep loss in relation to sex steroids. Psychoneuroendocrinology. 2019;108:87–93. doi: 10.1016/j.psyneuen.2019.05.027 PubMed DOI

Mota MC, et al. . Social jetlag and metabolic control in non-communicable chronic diseases: a study addressing different obesity statuses. Sci Rep. 2017;7(1):6358. doi: 10.1038/s41598-017-06723-w PubMed DOI PMC

Girtman KL, et al. . Later sleep timing and social jetlag are related to increased inflammation in a population with a high proportion of OSA: findings from the Cleveland Family Study. J Clin Sleep Med. 2022;18(9):2179–2187. doi: 10.5664/jcsm.10078 PubMed DOI PMC

Beauvalet JC, et al. . Social jetlag in health and behavioral research: a systematic review. ChronoPhysiology Ther. 2017;7:19–31. doi: 10.2147/CPT.S108750 DOI

Sladek M, et al. . Chronotype assessment via a large scale socio-demographic survey favours yearlong Standard time over Daylight Saving Time in central Europe. Sci Rep. 2020;10(1):1419. doi: 10.1038/s41598-020-58413-9 PubMed DOI PMC

Roenneberg T, et al. . Epidemiology of the human circadian clock. Sleep Med Rev. 2007;11(6):429–438. doi: 10.1016/j.smrv.2007.07.005 PubMed DOI

Jones E, et al. . SciPy: Open Source Scientific Tools for Python [computer program]. 2001.

van der Maaten L, et al. . Visualizing data using t-SNE. J Mach Learn Res. 2008;9(86):2579–2605.

Pedregosa F, et al. . Scikit-learn: machine learning in Python. J Mach Learn Res. 2011;12:2825–2830.

Seabold S, et al. . Statsmodels: econometric and statistical modeling with python. In: Proceedings from the 9th Python in Science Conference; 2010; Austin, Texas.

Kudrnáčová M. Czech Household Panel Survey. Data Documentation [Internet]. 2019. http://dspace.soc.cas.cz:8080/xmlui/handle/123456789/3780. Accessed January 19, 2021.

Castro N, et al. . Social jetlag and cardiometabolic risk in preadolescent children. Front Cardiovasc Med. 2021;8:705169. doi: 10.3389/fcvm.2021.705169 PubMed DOI PMC

Rusu A, et al. . Social jetlag, sleep-related parameters, and glycemic control in adults with type 1 diabetes: results of a cross-sectional study. J Diabetes. 2019;11(5):394–401. doi: 10.1111/1753-0407.12867 PubMed DOI

Dobiasova M, et al. . The plasma parameter log (TG/HDL-C) as an atherogenic index: correlation with lipoprotein particle size and esterification rate in apoB-lipoprotein-depleted plasma (FER(HDL)). Clin Biochem. 2001;34(7):583–588. doi: 10.1016/s0009-9120(01)00263-6 PubMed DOI

McMahon DM, et al. . Relationships between chronotype, social jetlag, sleep, obesity and blood pressure in healthy young adults. Chronobiol Int. 2019;36(4):493–509. doi: 10.1080/07420528.2018.1563094 PubMed DOI

Patterson F, et al. . Interactive effects of sleep duration and morning/evening preference on cardiovascular risk factors. Eur J Public Health. 2018;28(1):155–161. doi: 10.1093/eurpub/ckx029 PubMed DOI PMC

O’Byrne NA, et al. . Sleep and circadian regulation of cortisol: a short review. Curr Opin Endocr Metab Res. 2021;18:178–186. doi: 10.1016/j.coemr.2021.03.011 PubMed DOI PMC

Shea SA, et al. . Independent circadian and sleep/wake regulation of adipokines and glucose in humans. J Clin Endocrinol Metab. 2005;90(5):2537–2544. doi: 10.1210/jc.2004-2232 PubMed DOI PMC

Wehrens SMT, et al. . Meal timing regulates the human circadian system. Curr Biol. 2017;27(12):1768–1775.e3. doi: 10.1016/j.cub.2017.04.059 PubMed DOI PMC

Leung GKW, et al. . Effect of meal timing on postprandial glucose responses to a low glycemic index meal: a crossover trial in healthy volunteers. Clin Nutr. 2019;38(1):465–471. doi: 10.1016/j.clnu.2017.11.010 PubMed DOI

Zhang Z, et al. . Social jetlag and chronotypes in the chinese population: analysis of data recorded by wearable devices. J Med Internet Res. 2019;21(6):e13482. doi: 10.2196/13482 PubMed DOI PMC

Tavernier R, et al. . Perceived morningness-eveningness predicts academic adjustment and substance use across university, but social jetlag is not to blame. Chronobiol Int. 2015;32(9):1233–1245. doi: 10.3109/07420528.2015.1085062 PubMed DOI

Suikki T, et al. . Association between social jet lag, quality of diet and obesity by diurnal preference in Finnish adult population. Chronobiol Int. 2021;38(5):720–731. doi: 10.1080/07420528.2021.1876721 PubMed DOI

Martinez-Lozano N, et al. . Evening types have social jet lag and metabolic alterations in school-age children. Sci Rep. 2020;10(1):16747. doi: 10.1038/s41598-020-73297-5 PubMed DOI PMC

Bottary R, et al. . Social jetlag is independently associated with chronotype and poor memory for extinguished fear. Exp Results. 2020;1:1–8. doi: 10.1017/exp.2020.26 DOI

Takaesu Y, et al. . Association of sleep duration on workdays or free days and social jetlag with job stress. Psychiatry Clin Neurosci. 2021;75(8):244–249. doi: 10.1111/pcn.13274 PubMed DOI

Mathew GM, et al. . Sleep duration and social jetlag are independently associated with anxious symptoms in adolescents. Chronobiol Int. 2019;36(4):461–469. doi: 10.1080/07420528.2018.1509079 PubMed DOI PMC

Lehto JE, et al. . School burnout and sleep in Finnish secondary school students. Sleep Sci. 2019;12(1):10–14. doi: 10.5935/1984-0063.20190051 PubMed DOI PMC

Waleriańczyk W, et al. . Testing the role of midpoint sleep and social jetlag in the context of work psychology: an exploratory study. Biol Rhythm Res. 2020;51(7):1026–1043. doi: 10.1080/09291016.2019.1571707 DOI

Cespedes Feliciano EM, et al. . Chronotype, social jet lag, and cardiometabolic risk factors in early adolescence. JAMA Pediatr. 2019. doi: 10.1001/jamapediatrics.2019.3089 PubMed DOI PMC

Diaz-Morales JF, et al. . Social jetlag, academic achievement and cognitive performance: understanding gender/sex differences. Chronobiol Int. 2015;32(6):822–831. doi: 10.3109/07420528.2015.1041599 PubMed DOI

Liang F, et al. . Associations of social jetlag with dietary behavior, physical activity and obesity among Chinese adolescents. Nutrients. 2022;14(3):510. doi: 10.3390/nu14030510 PubMed DOI PMC

Alves MS, et al. . Social jetlag among night workers is negatively associated with the frequency of moderate or vigorous physical activity and with energy expenditure related to physical activity. J Biol Rhythms. 2017;32(1):83–93. doi: 10.1177/0748730416682110 PubMed DOI

Zerbini G, et al. . Strategies to decrease social jetlag: reducing evening blue light advances sleep and melatonin. Eur J Neurosci. 2018;51(12):2355–2366. doi: 10.1111/ejn.14293 PubMed DOI

Genta FD, et al. . COVID-19 pandemic impact on sleep habits, chronotype, and health-related quality of life among high school students: a longitudinal study. J Clin Sleep Med. 2021;17(7):1371–1377. doi: 10.5664/jcsm.9196 PubMed DOI PMC

Korman M, et al. . COVID-19-mandated social restrictions unveil the impact of social time pressure on sleep and body clock. Sci Rep. 2020;10(1):22225. doi: 10.1038/s41598-020-79299-7 PubMed DOI PMC

Mota MC, et al. . Association between social jetlag food consumption and meal times in patients with obesity-related chronic diseases. PLoS One. 2019;14(2):e0212126. doi: 10.1371/journal.pone.0212126 PubMed DOI PMC

Zarrinpar A, et al. . Daily eating patterns and their impact on health and disease. Trends Endocrinol Metab. 2016;27(2):69–83. doi: 10.1016/j.tem.2015.11.007 PubMed DOI PMC

Makarem N, et al. . Variability in daily eating patterns and eating jetlag are associated with worsened cardiometabolic risk profiles in the American Heart Association Go Red for women strategically focused research network. J Am Heart Assoc. 2021;10(18):e022024. doi: 10.1161/JAHA.121.022024 PubMed DOI PMC

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