Helminthic host defense peptides: using the parasite to defend the host
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články, přehledy, práce podpořená grantem
PubMed
36890022
DOI
10.1016/j.pt.2023.02.004
PII: S1471-4922(23)00033-8
Knihovny.cz E-zdroje
- Klíčová slova
- antimicrobial peptides, helminths, host defense peptides, immunity, microbiome,
- MeSH
- Bacteria MeSH
- cizopasní červi * MeSH
- kationické antimikrobiální peptidy MeSH
- paraziti * MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- kationické antimikrobiální peptidy MeSH
Parasitic helminths are destined to share niches with a variety of microbiota that inevitably influence their interaction with the host. To modulate the microbiome for their benefit and defend against pathogenic isolates, helminths have developed host defense peptides (HDPs) and proteins as integral elements of their immunity. These often exert a relatively nonspecific membranolytic activity toward bacteria, sometimes with limited or no toxicity toward host cells. With a few exceptions, such as nematode cecropin-like peptides and antibacterial factors (ABFs), helminthic HDPs are largely underexplored. This review scrutinizes current knowledge on the repertoire of such peptides in helminths and promotes their research as potential leads for an anti-infective solution to the burgeoning problem of antibiotic resistance.
Department of Biology Faculty of Science University of Split Ruđera Boškovića 33 Split 21000 Croatia
Department of Life Sciences University of Trieste Trieste 34127 Italy
Citace poskytuje Crossref.org