INTRODUCTION: The role of eicosanoids, metabolites of arachidonic acid with cardio-renal activity, remains unclear in human heart failure (HF). METHODS: We enrolled 50 patients with HF to measure plasma 14,15-EET and 14,15-DHET levels using commercial ELISA kits and compared them with 25 age- and sex-matched controls. RESULTS: Both of the measured eicosanoids were significantly higher in the HF group: 14,15-EET (91.3 ±25.7 ng/ml vs. 64.95 ±35.4 ng/ml) and 14,15-DHET (10.58 ±2.06 ng/ml vs. 9.07 ±1.60 ng/ml), p for both < 0.001. CONCLUSIONS: We found that peripheral plasma eicosanoid (14,15-EET, 14,15-DHET) levels are raised in patients with HF compared to age- and sex-matched controls.

Center of Experimental Medicine Institute of Clinical and Experimental Medicine Prague Czech Republic

Department of Cardiology University Hospital Motol and 2 Faculty of Medicine Charles University Prague Czech Republic

Department of Medical Chemistry and Biochemistry University Hospital Motol and 2 Faculty of Medicine Charles University Prague Czech Republic

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Conrad N, Judge A, Tran J, et al. . Temporal trends and patterns in heart failure incidence: a population-based study of 4 million individuals. Lancet 2018; 391: 572-80. PubMed PMC

McDonagh TA, Metra M, Adamo M, et al. . 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J 2021; 42: 3599-726. PubMed

Arundel C, Lam PH, Faselis C, et al. . Length of stay and readmission in older adults hospitalized for heart failure. Arch Med Sci 2021; 17: 891-9. PubMed PMC

Vaduganathan M, Claggett BL, Jhund PS, et al. . Estimating lifetime benefits of comprehensive disease-modifying pharmacological therapies in patients with heart failure with reduced ejection fraction: a comparative analysis of three randomised controlled trials. Lancet 2020; 396: 121-8. PubMed

Imig JD, Cervenka L, Neckar J. Epoxylipids and soluble epoxide hydrolase in heart diseases. Biochem Pharmacol 2022; 195: 114866. PubMed PMC

Fan F, Roman RJ. Effect of cytochrome P450 metabolites of arachidonic acid in nephrology. J Am Soc Nephrol 2017; 28: 2845-55. PubMed PMC

Lai J, Chen C. The role of epoxyeicosatrienoic acids in cardiac remodeling. Front Physiol 2021; 12: 642470. PubMed PMC

Fleming I. The pharmacology of the cytochrome P450 epoxygenase/soluble epoxide hydrolase axis in the vasculature and cardiovascular disease. Pharmacol Rev 2014; 66: 1106-40. PubMed

Imig JD, Elmarakby A, Nithipatikom K, et al. . Development of epoxyeicosatrienoic acid analogs with in vivo anti-hypertensive actions. Front Physiol 2010; 1: 157. PubMed PMC

Gawrys O, Husková Z, Baranowska I, et al. . Combined treatment with epoxyeicosatrienoic acid analog and 20-hydroxyeicosatetraenoic acid antagonist provides substantial hypotensive effect in spontaneously hypertensive rats. J Hypertens 2020; 38: 1802-10. PubMed

Kala P, Miklovič M, Jíchová Š, et al. . Effects of epoxyeicosatrienoic acid-enhancing therapy on the course of congestive heart failure in angiotensin ii-dependent rat hypertension: from mRNA analysis towards functional in vivo evaluation. Biomedicines 2021; 9: 1053. PubMed PMC

Elmarakby AA. Reno-protective mechanisms of epoxyeicosatrienoic acids in cardiovascular disease. Am J Physiol Regul Integr Comp Physiol 2012; 302: R321-30. PubMed

Sporková A, Redd RN, Falck JR, et al. . Interlobular arteries from 2-kidney, 1-clip goldblatt hypertensive rats’ exhibit-impaired vasodilator response to epoxyeicosatrienoic acids. Am J Med Sci 2016; 351: 513-9. PubMed PMC

Long-chain polyunsaturated fatty acid-containing phosphatidylcholines predict survival rate in patients after heart failure