Závažná autoimunitní tyreotoxikóza komplikovaná febrilní neutropenií jako nežádoucí účinek tyreostatické léčby
[Severe autoimune thyreotoxicosis complicated by febrile neutropenia as a result of thyreostatic therapy]
Language Czech Country Czech Republic Media print
Document type Journal Article
PubMed
37072262
DOI
10.36290/vnl.2023.024
PII: 134011
- Keywords
- Lugol solution, agranulocytosis, hyperthyreoidism, hyperthyroidism, thyrotoxic crisis, total thyreoidectomy,
- MeSH
- Febrile Neutropenia * complications drug therapy MeSH
- Hyperthyroidism * complications MeSH
- Humans MeSH
- Antithyroid Agents therapeutic use MeSH
- Thyroid Crisis * drug therapy etiology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Antithyroid Agents MeSH
Hyperthyreoidism is a clinical manifestation of excessive production of thyroid hormones. In most cases pacient ´s condition allows ambulant treatment. Rarely, it can develop into an acute, life- threatening thyrotoxic crisis which has to be treated in the intensive care unit. Main therapy includes antithyroid medication, corticosteroids, beta- blockers and rehydratation, mostly parenteral. If initial treatment fails, plasmapheresis provides effective strategy. Antithyroid medication may come with side effects as rash, digestive issues, joint pain.Agranulocystosis or acute liver lesion which leads to liver failure belong among the most severe ones. In this case we report a pacient with thyrotoxic crisis, atrial fibrilation which led to ventricular fibrilation, cor thyreotoxicum. The treatment was complicated by febrile neutropenia.
References provided by Crossref.org