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Závažná autoimunitní tyreotoxikóza komplikovaná febrilní neutropenií jako nežádoucí účinek tyreostatické léčby
[Severe autoimune thyreotoxicosis complicated by febrile neutropenia as a result of thyreostatic therapy]

. 2023 Spring ; 69 (E-2) : 19-22.

Language Czech Country Czech Republic Media print

Document type Journal Article

Links

PubMed 37072262
DOI 10.36290/vnl.2023.024
PII: 134011

Hyperthyreoidism is a clinical manifestation of excessive production of thyroid hormones. In most cases pacient ´s condition allows ambulant treatment. Rarely, it can develop into an acute, life- threatening thyrotoxic crisis which has to be treated in the intensive care unit. Main therapy includes antithyroid medication, corticosteroids, beta- blockers and rehydratation, mostly parenteral. If initial treatment fails, plasmapheresis provides effective strategy. Antithyroid medication may come with side effects as rash, digestive issues, joint pain.Agranulocystosis or acute liver lesion which leads to liver failure belong among the most severe ones. In this case we report a pacient with thyrotoxic crisis, atrial fibrilation which led to ventricular fibrilation, cor thyreotoxicum. The treatment was complicated by febrile neutropenia.

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