Mineralocorticoid receptor blockade protects the kidneys but does not affect inverted blood pressure rhythm in hypertensive transgenic (mRen-2)27 rats
Jazyk angličtina Země Irsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
37210027
DOI
10.1016/j.mce.2023.111967
PII: S0303-7207(23)00118-1
Knihovny.cz E-zdroje
- Klíčová slova
- Blood pressure, Kidney function, Salt load, Spironolactone, TGR (mRen-2)27 rats,
- MeSH
- albuminurie MeSH
- aldosteron * farmakologie MeSH
- antagonisté mineralokortikoidních receptorů farmakologie MeSH
- geneticky modifikovaná zvířata MeSH
- hypertenze * MeSH
- krevní tlak MeSH
- krysa rodu Rattus MeSH
- ledviny MeSH
- receptory mineralokortikoidů genetika MeSH
- spironolakton farmakologie MeSH
- voda farmakologie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- aldosteron * MeSH
- antagonisté mineralokortikoidních receptorů MeSH
- receptory mineralokortikoidů MeSH
- spironolakton MeSH
- voda MeSH
Aldosterone regulates blood pressure (BP) through water and sodium balance. In our study, we studied if continuous treatment with a mineralocorticoid receptor antagonist, spironolactone (30 mg/kg/day) for 20 days can: 1) attenuate hypertension development and restore inverted 24-h BP rhythm in hypertensive transgenic (mRen-2)27 rats (TGR) measured by telemetry; 2) improve function of the kidneys and heart; 3) be protective against high salt load (1% in water) by mitigating oxidative injury and improving kidney function. Spironolactone decreased albuminuria and 8-isoprostane in normal and salt load conditions in BP-independent effects. Salt load increased BP, impaired autonomic balance, suppressed plasma aldosterone level and increased natriuresis, albuminuria and oxidative injury in TGR. Spironolactone did not restore the inverted 24-h rhythm of BP in TGR, therefore, mineralocorticoids are not crucial in regulation of BP daily profile. Spironolactone improved kidney function, decreased oxidative stress and was protective against high salt load in the BP-independent manner.
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