CD44 mediated colon cancer targeting mutlifaceted lignin nanoparticles: Synthesis, in vitro characterization and in vivo efficacy studies
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
37499773
DOI
10.1016/j.ijpharm.2023.123270
PII: S0378-5173(23)00690-7
Knihovny.cz E-zdroje
- Klíčová slova
- Active targeting, Hyaluronic acid, Lignin nanoparticles, Mitochondrial depolarization, Solid tumor, hyaluronan/CD44 receptors,
- MeSH
- antigeny CD44 metabolismus MeSH
- irinotekan farmakologie MeSH
- kyselina hyaluronová chemie MeSH
- lignin MeSH
- myši MeSH
- nádorové buněčné linie MeSH
- nádory tračníku * farmakoterapie MeSH
- nanočástice * chemie MeSH
- protinádorové látky * chemie MeSH
- tkáňová distribuce MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antigeny CD44 MeSH
- irinotekan MeSH
- kyselina hyaluronová MeSH
- lignin MeSH
- protinádorové látky * MeSH
Hyaluronic acid (HA) coated irinotecan loaded lignin nanoparticles (HDLNPs) were synthesized using ionic interaction method. Optimized nanoparticles were characterized for their active chemotherapeutic targeting potential to CD44 receptors overly-expressed on cancer cells. Blood component interaction studies supported hemocompatible nature of HDLNPs and also demonstrated their sustained plasma residence property. Cell anti-proliferation and mitochondrial depolarization studies on HT-29 cells suggest significantly (p < 0.01) improved chemotherapeutic efficacy of HDLNPs. In vitro cell based studies showed that nanoparticles have retained antioxidant activity of lignin that can prevent cancer relapse. In vivo biodistribution studies in tumor-bearing Balb/c mice confirmed improved drug localization in tumor site for longer duration. Tumor regression and histopathological studies indicated the efficacy ofligand-assisted targeting chemotherapy over the conventional therapy. Hematological and biochemical estimation suggested that irinotecan-associated myelosuppression, liver steatosis and rare kidney failure can be avoided by its encapsulation in HA-coated lignin nanoparticles. HDLNPs were found to be stable over a period of 12 months.
Cell Biology Lab Dabur Research Foundation Ghaziabad UP India
Department of Production Engineering Warsaw University of Life Sciences Poland
Faculty of Business and Economics Mendel University in Brno Brno Czech Republic
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