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The Global, Regional, and National Burden of Adult Lip, Oral, and Pharyngeal Cancer in 204 Countries and Territories: A Systematic Analysis for the Global Burden of Disease Study 2019

. 2023 Oct 01 ; 9 (10) : 1401-1416.

Language English Country United States Media print

Document type Journal Article, Systematic Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural

Grant support
001 World Health Organization - International

IMPORTANCE: Lip, oral, and pharyngeal cancers are important contributors to cancer burden worldwide, and a comprehensive evaluation of their burden globally, regionally, and nationally is crucial for effective policy planning. OBJECTIVE: To analyze the total and risk-attributable burden of lip and oral cavity cancer (LOC) and other pharyngeal cancer (OPC) for 204 countries and territories and by Socio-demographic Index (SDI) using 2019 Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study estimates. EVIDENCE REVIEW: The incidence, mortality, and disability-adjusted life years (DALYs) due to LOC and OPC from 1990 to 2019 were estimated using GBD 2019 methods. The GBD 2019 comparative risk assessment framework was used to estimate the proportion of deaths and DALYs for LOC and OPC attributable to smoking, tobacco, and alcohol consumption in 2019. FINDINGS: In 2019, 370 000 (95% uncertainty interval [UI], 338 000-401 000) cases and 199 000 (95% UI, 181 000-217 000) deaths for LOC and 167 000 (95% UI, 153 000-180 000) cases and 114 000 (95% UI, 103 000-126 000) deaths for OPC were estimated to occur globally, contributing 5.5 million (95% UI, 5.0-6.0 million) and 3.2 million (95% UI, 2.9-3.6 million) DALYs, respectively. From 1990 to 2019, low-middle and low SDI regions consistently showed the highest age-standardized mortality rates due to LOC and OPC, while the high SDI strata exhibited age-standardized incidence rates decreasing for LOC and increasing for OPC. Globally in 2019, smoking had the greatest contribution to risk-attributable OPC deaths for both sexes (55.8% [95% UI, 49.2%-62.0%] of all OPC deaths in male individuals and 17.4% [95% UI, 13.8%-21.2%] of all OPC deaths in female individuals). Smoking and alcohol both contributed to substantial LOC deaths globally among male individuals (42.3% [95% UI, 35.2%-48.6%] and 40.2% [95% UI, 33.3%-46.8%] of all risk-attributable cancer deaths, respectively), while chewing tobacco contributed to the greatest attributable LOC deaths among female individuals (27.6% [95% UI, 21.5%-33.8%]), driven by high risk-attributable burden in South and Southeast Asia. CONCLUSIONS AND RELEVANCE: In this systematic analysis, disparities in LOC and OPC burden existed across the SDI spectrum, and a considerable percentage of burden was attributable to tobacco and alcohol use. These estimates can contribute to an understanding of the distribution and disparities in LOC and OPC burden globally and support cancer control planning efforts.

Academic Public Health England Public Health England London England United Kingdom

Advanced Dental Sciences Research Center Kermanshah University of Medical Sciences Kermanshah Iran

Amity Institute of Forensic Sciences Amity University Noida India

Applied Biomedical Research Center Mashhad University of Medical Sciences Mashhad Iran

Associazione Italiana Ricerca Oncologica di Base Padova Italy

Australian Research Centre for Population Oral Health University of Adelaide Adelaide South Australia Australia

Biotechnology Research Center Mashhad University of Medical Sciences Mashhad Iran

Cancer Control and Population Sciences Program University of Florida Health Cancer Center Gainesville

Cancer Registry of Norway Oslo Norway

Caspian Digestive Disease Research Center Guilan University of Medical Sciences Rasht Iran

Center for Biomedicine and Community Health International School Vietnam National University Hanoi Vietnam

Center for Biotechnology and Microbiology University of Swat Mingora Pakistan

Centre for Applied Health Economics Griffith University Gold Coast Queensland Australia

Centre for Community Medicine All India Institute of Medical Sciences New Delhi India

Centre for Social Research in Health University of New South Wales Sydney New South Wales Australia

Children's Medical Center Tehran University of Medical Sciences Tehran Iran

Clinical and Epidemiological Research in Primary Care Cordoba Spain

Clinical Sciences Department University of Sharjah Sharjah United Arab Emirates

College of Dental Medicine Qatar University Doha Qatar

College of Dentistry Jazan University Jazan Saudi Arabia

College of Medicine University of Sharjah Sharjah United Arab Emirates

College of Nursing and Health Sciences Flinders University Adelaide South Australia Australia

Competence Center of Mortality Follow Up of the German National Cohort Federal Institute for Population Research Wiesbaden Germany

Computer Electrical and Mathematical Sciences and Engineering Division King Abdullah University of Science and Technology Thuwal Saudi Arabia

Czech National Centre for Evidence based Healthcare and Knowledge Translation Masaryk University Brno Czech Republic

Czech National Centre for Evidence Based Healthcare and Knowledge Translation Masaryk University Brno Czech Republic

Department of Anatomy All India Institute of Medical Sciences Jodhpur India

Department of Anatomy Royal College of Surgeons in Ireland Medical University of Bahrain Busaiteen Bahrain

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Department of Biochemistry Government Medical College Mysuru India

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Department of Internal Medicine Mount Auburn Hospital Harvard University Cambridge Massachusetts

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Institute of Research and Development Duy Tan University Da Nang Vietnam

Internal Medicine Department King Saud University Riyadh Saudi Arabia

International Center of Medical Sciences Research Islamabad Pakistan

Kasturba Medical College Mangalore Manipal Academy of Higher Education Mangalore India

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Laboratory Technology Sciences Department Yasuj University of Medical Sciences Yasuj Iran

Living Systems Institute University of Exeter Exeter England United Kingdom

Manipal College of Dental Sciences Manipal Manipal Academy of Higher Education Manipal India

MAZUMS Office Universal Scientific Education and Research Network Tehran Iran

Medical Ain Shams Research Institute Ain Shams University Cairo Egypt

Medical Laboratory Sciences Sirjan School of Medical Sciences Sirjan Iran

Ministry of Health Herrera Panama

Modestum LTD Eastbourne England United Kingdom

Multidisciplinary Laboratory Foundation University School of Health Sciences Foundation University Islamabad Pakistan

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National Data Management Center for Health Ethiopian Public Health Institute Addis Ababa Ethiopia

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National Institute of Epidemiology Indian Council of Medical Research Chennai India

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Non Communicable Diseases Committee National Institute for Medical Research Development Tehran Iran

Non Communicable Diseases Research Center Tehran University of Medical Sciences Tehran Iran

Obesity Research Center Shahid Beheshti University of Medical Sciences Tehran Iran

Oncological Network Institute for Cancer Research Prevention and Clinical Network Florence Italy

Oral Medicine Clinic School of Dentistry University of Washington Seattle

Pathology and Laboratory Medicine Institute Cleveland Clinic Cleveland Ohio

Pathology Department Alexandria University Alexandria Egypt

Pohang University of Science and Technology Pohang South Korea

Polish Mothers' Memorial Hospital Research Institute Lodz Poland

Population and Patient Health Group King's College London London England United Kingdom

Postgraduate Institute of Medicine University of Colombo Colombo Sri Lanka

Public Health Center Ministry of Health and Welfare Wando South Korea

Public Health Foundation of India Gurugram India

Public Health Sciences Division Fred Hutchinson Cancer Research Center Seattle Washington

Quality and Systems Performance Unit Cancer Institute NSW Sydney New South Wales Australia

Rabigh Faculty of Medicine King Abdulaziz University Jeddah Saudi Arabia

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Research Center for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran

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Saveetha Dental College and Hospitals Saveetha Institute of Medical and Technical Sciences Chennai India

Saveetha Medical College and Hospitals Saveetha Institute of Medical and Technical Sciences Chennai India

School of Dentistry and Medical Sciences Charles Sturt University Orange New South Wales Australia

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