Reference values of parathyroid hormone in very low birth weight infants
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články
- Klíčová slova
- Parathyroid hormone, hyperparathyroidism, preterm infants, reference range,
- MeSH
- alkalická fosfatasa krev MeSH
- fosfor krev moč MeSH
- kreatinin krev moč MeSH
- lidé MeSH
- novorozenec s velmi nízkou porodní hmotností * krev moč MeSH
- novorozenec MeSH
- parathormon * krev MeSH
- referenční hodnoty MeSH
- vápník * krev moč MeSH
- vitamin D krev analogy a deriváty MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- novorozenec MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- 25-hydroxyvitamin D MeSH Prohlížeč
- alkalická fosfatasa MeSH
- fosfor MeSH
- kreatinin MeSH
- parathormon * MeSH
- vápník * MeSH
- vitamin D MeSH
PURPOSE: The primary goal was to estimate reference values of parathyroid hormone (PTH) in very low birth weight infants without severe neonatal morbidity. A secondary objective was to assess the relationship between PTH serum levels and selected laboratory markers of bone metabolism. METHODS: Ninety two infants with birth weight less than 1500 g met the inclusion criteria of the study. Serum levels of PTH, 25-hydroxyvitamin-D [25(OH)D], C3-epi-25(OH)D, total calcium, phosphorus, and alkaline phosphatase, and urinary levels of calcium, phosphorus, and creatinine were examined on day 14 and subsequently every 2 weeks until discharge. RESULTS: Of the total 167 serum samples examined for PTH levels in infants without 25(OH)D deficiency the estimated range was 0.9-11.9 pmol/l (8.5-112.3 pg/mL). During the first month, no statistically significant correlation was observed between PTH level and that of 25(OH)D, C3-epimers of 25(OH)D, S-Ca, S-P, or ALP, nor with urinary excretion of calcium and phosphorus. From the second month of life, there was a moderately significant correlation between PTH and 25(OH)D (Rho = -0.40, P =< .001), between PTH and calcium/creatinine ratio (Rho = -0.56, P = < .001), and between PTH and phosphorus/creatinine ratio (Rho = 0.51, P = < .001). CONCLUSIONS: The physiological range for PTH levels for preterm neonates without 25(OH)D deficiency was estimated as 0.9-11.9 pmol/l (8.5-112.3 pg/mL). It seems that elevation of serum PTH above this range can be considered as hyperparathyroidism in very low birth weight infants.
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Vitamin D metabolome in preterm infants: insights into postnatal metabolism
