Silver-enriched microdomain patterns as advanced bactericidal coatings for polymer-based medical devices
Language English Country Netherlands Media print-electronic
Document type Journal Article
PubMed
38981327
DOI
10.1016/j.colsurfb.2024.114067
PII: S0927-7765(24)00326-6
Knihovny.cz E-resources
- Keywords
- Antibacterial efficacy, Bioapplication, Laser-induced immobilization, Polyetheretherketone, Silver nanoparticles,
- MeSH
- Anti-Bacterial Agents * pharmacology chemistry MeSH
- Benzophenones * chemistry pharmacology MeSH
- Coated Materials, Biocompatible chemistry pharmacology MeSH
- Escherichia coli * drug effects MeSH
- Ketones chemistry pharmacology MeSH
- Metal Nanoparticles * chemistry MeSH
- Humans MeSH
- Microbial Sensitivity Tests * MeSH
- Polyethylene Glycols * chemistry pharmacology MeSH
- Polymers * chemistry pharmacology MeSH
- Surface Properties MeSH
- Staphylococcus aureus * drug effects MeSH
- Silver * chemistry pharmacology MeSH
- Particle Size MeSH
- Equipment and Supplies microbiology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Anti-Bacterial Agents * MeSH
- Benzophenones * MeSH
- Coated Materials, Biocompatible MeSH
- Ketones MeSH
- polyetheretherketone MeSH Browser
- Polyethylene Glycols * MeSH
- Polymers * MeSH
- Silver * MeSH
Today, it would be difficult for us to live a full life without polymers, especially in medicine, where its applicability is constantly expanding, giving satisfactory results without any harm effects on health. This study focused on the formation of hexagonal domains doped with AgNPs using a KrF excimer laser (λ=248 nm) on the polyetheretherketone (PEEK) surface that acts as an unfailing source of the antibacterial agent - silver. The hexagonal structure was formed with a grid placed in front of the incident laser beam. Surfaces with immobilized silver nanoparticles (AgNPs) were observed by AFM and SEM. Changes in surface chemistry were studied by XPS. To determine the concentration of released Ag+ ions, ICP-MS analysis was used. The antibacterial tests proved the antibacterial efficacy of Ag-doped PEEK composites against Escherichia coli and Staphylococcus aureus as the most common pathogens. Because AgNPs are also known for their strong toxicity, we also included cytotoxicity tests in this study. The findings presented here contribute to the advancement of materials design in the biomedical field, offering a novel starting point for combating bacterial infections through the innovative integration of AgNPs into inert synthetic polymers.
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