INTRODUCTION: The Hueter-Volkmann law (HVL) of the response of growth plate to compression load is a basic concept in orthopaedics. However, little is known about the origin of HVL and its history. MATERIALS AND METHODS: A literature search was performed in original publications and historical sources. RESULTS: An analysis of all Volkmann´s and Hueter´s texts has shown that none of their publications was based on experiments, but on the data in the literature and their own clinical observations. They did not deal at all with the effect of pressure on the growth plate and mentioned this structure only marginally. The authors coined the opinion that increased pressure retards and decreased pressure accelerates bone growth. Julius Wolff criticized the HVL and concentrated all his arguments in the book "The law of bone remodeling". According to him, increased pressure leads to bone formation, decreased pressure to its resorption. The Wolff-Volkmann dispute was addressed in the German literature by a number of authors. Walther Müller in his monograph "The normal and pathological physiology of the bone" criticized Wolff for his concept of interstitial bone growth. In Müller´s view, HVL applies to the growing bone and Wolff confuses growth with hypertrophy of the mature bone. CONCLUSION: The circumstances of the emergence of HVL are inaccurately and incompletely described in the current literature, as they are mostly taken from secondary sources. HVL, as it is presented today, is not the original formulation, but the result of a long historical evolution.

Department of Orthopedics 1st Faculty of Medicine Charles University and the Central Military Hospital U Vojenské nemocnice 1200 Prague 6 Czech Republic

Institute of Anatomy 1st Faculty of Medicine Charles University U Nemocnice 3 128 00 Prague 2 Czech Republic

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Sledge CB, Noble J (1978) Experimental limb lengthening by epiphyseal distraction. Clin Orthop Relat Res 136:111–119 PubMed

Simon MR (1978) The effect of dynamic loading on the growth of epiphyseal cartilage in the rat. Acta Anat (Basel) 102:176–183. 10.1159/000145635 PubMed

Mau H (1984) Spezifizierung der korrespondierenden Wachstums-Gesetze von Hueter-Volkmann und Pauwels (Wachstumsdeformitäten) und ihre Beziehung zu den Belastungsdeformitäten. Z Orthop Ihre Grenzgeb 122:293–298. 10.1055/s-2008-1044629 PubMed

Mehlman CT, Araghi A, Roy DR (1997) Hyphenated history: the Hueter-Volkmann law. Am J Orthop 26:798–800 PubMed

Stokes IA (2002) Mechanical effects on skeletal growth. J Musculoskelet Neuronal Interact 2(3):277–280 PubMed

Rauch F (2005) Bone growth in length and width: the Yin and Yang of bone stability. J Musculoskelet Neuronal Interact 5:194–201 PubMed

Willy C, Schneider P, Engelhardt M, Hargens AR, Mubarak SJ (2008) Richard Von Volkmann: surgeon and Renaissance man. Clin Orthop Relat Res 466:500–506. 10.1007/s11999-007-0007-4 PubMed PMC

Carsen S, Grammatopoulos G, Zaltz I, Ward L, Smit K, Beaulé PE (2021) The effects of physical activity on physeal and skeletal development. JBJS Rev. 12;9(10). 10.2106/JBJS.RVW.21.00060 PubMed

Villemure I, Stokes IA (2009) Growth plate mechanics and mechanobiology. A survey of present understanding. J Biomech 42:1793–1803. 10.1016/j.jbiomech.200905.021 PubMed PMC

Bartoníček J, Naňka O (2024) Early history of the study of bone growth (1722–1875). Int Orthop 48(7):1915–1922. 10.1007/s00264-024-06157-w PubMed PMC

Hunter J (1837) The work of John Hunter. (Palmer’s edition 1837). London, Longman 1835–1837

Flourens P (1847) Théorie expérimentale de la formation des os. Paris, Bailliere

Kölliker A (1873) Die normale Resorption des Knochengewebes und ihre Bedeutung für die Entstehung der typischen Knochenformen. Leipzig, Vogel

Wegner G (1874) Ueber das normale und pathologische Wachsthum der Rohrenknochen. (Virchows Archiv) 61:44–76

Miescher F (1836) De inflamatio ossium eorumque anatome generali. Berlin, Eichler

Tod RB, Bowman W (1845) Physiological anatomy and physiology of man. JW Parker, West Strand, London

Quain R, Sharpey W (eds) (1848) Element of anatomy by Jones Quain. Fifth edition. London, Taylor, Walton and Maberly

Hassal AH (1849) The microscopic anatomy of the human body, in health and disease. Samuel Highley, London

Tomes J, De Morgan C (1853) The structure and development of bone. Philosophical Trans 149:109–139. 10.1098/rstl.1853.00041

Müller H (1858) Ueber der Entwicklung der Knochensubstanz nebst Bemerkungen über den Bau rachitischer Knochen. Leipzig, Engelmann

Virchow R (1853) Das normale Knochenwachsthum und rachitische Störung desselbes. Virchow Archiv Pathol Anat (Virchows Archiv) 5:409–507

Wegner G (1870) Ueber hereditäre Knochensyphilis bei Jungen Kindern. Archiv Pathol Anat (Virchows Archiv) 50:305–322. 10.1007/BF01944486

Debrunner H (1932) Richard v. Volkmann. Studien zur Darstellung von Mensch und Werk. Archiv Orthop-Unfall Chir (Arch Orthop Trauma Chir) 31:512–613

Bartoníček J, Rammelt S (2015) Early history of operative treatment of patellar fractures. Int Orthop 39:2303–2308. 10.1007/s00264-015-2768-9 PubMed

Volkmann R (1881) Ischämische Muskellähmungen und -kontrakturen. Zentralbl Chir 8:801–803

Bartoníček J, Rammelt S, Naňka O (2023) Early history of posterior malleolus fractures in ankle fractures. Int Orthop. 10.1007/s00264-023-06080-6 PubMed

Volkmann R (1862) Chirurgische Erfahrungen über Knochenverbiegungen und Knochenwachsthum. Archiv Pathol Anat (Virchows Archiv) 24:512–540. 10.1007/BF01879454

Hueter C (1862) Anatomische Studien an den Extremitätengelenken Neugeborener und Erwachsener. Archiv Pathol Anat (Virchows Archiv). 25:572–599. 10.1007/BF01879806

Hueter C (1863) Anatomische Studien an den Extremitätengelenken Neugeborener und Erwachsener Archiv Pathol Anat (Virchows Archiv). 25:484–519

Duhamel HL (1743) Quatrieme et cinquieme memoires sur les os. Memoires De l’Academie Royale Des Sci 56:87–146

Hueter C (1864) Der Unterkiefer bein Neugebornen und Erwachsenen. Archiv Pathol Anat (Virchows Archiv) 29:121–142

Volkmann R (1865) Die Krankheiten der Bewegungsorgane. In: von Pitha FR, Billroth T (eds) Handbuch der allgemeinen und speziellen Chirurgie. Zweiter Band, Zweite Abteilung, Erste Hälfte, vol 333. Ferdinand Enke, Stuttgart, p 350–351

Volkmann R (1882) Die Krankheiten der Bewegungsorgane. In: von Pitha FR, Billroth T (eds) Handbuch der allgemeinen und speziellen Chirurgie. Zweiter Band, Zweite Abteilung, Erste Hälfte, vol 333. Ferdinand Enke, Stuttgart, pp 350–351

Volkmann R (1870) Notiz betreffend das intersticiale Knochenwachsthum. Centralblatt f Medizinische Wissenschaft 8:129–131

Wolff J (1868) Ueber Knochenwachsthum. Berliner Klinische Wochenschrift 5:62–64

von Meyer H (1867) Die Architectur der Spongiosa. Archiv Anat Physiol Wissench Med (Reichert und Dubois-Reymond’s. Archiv) 8:615–628

Bartoníček J, Alt J, Naňka O (2023) Internal architecture of the proximal femur: calcar femorale or Adams’ arch? Int Orthop 47:1871–1877. 10.1007/s00264-023-05764-3 PubMed PMC

Wolff J, Virchow R (1875) Einige Bemerkungen zum gegenwärtigen Stand der Knochenwachsthumsfrage. Archiv Pathol Anat (Virchows Archiv) 64:140–144. 10.1007/BF01986117

Wolff J (1874) Zur Knochenwachsthumsfrage. Archiv Pathol Anat (Virchows Archiv). 61:417–454. 10.1007/BF01962089

Wolff J (1892) Das Gesetz der Transformation der Knochen. Hirschwald, Berlin

Müller W (1924) Die normale und pathologische Physiologie des Knochens. Barth, Leipzig JA

Bergman E (1931) Über das Längewachstum der Knochen. Dtsch Z Chir 233:149–194

Gelbke H (1950) Tierexperimentelle Untersuchungen zur Frage des epiphysären Längenwachstums des Knochens unter Druck. Langenbecks Arch Klin Chir Ver Dtsch Z Chir 265:133–168 PubMed

Blount WP, Clarke GR (1949) Control of bone growth by epiphyseal stapling. J Bone Joint Surg Am 31A:464–478 PubMed

Arkin AM (1949) The mechanism of the structural changes in scoliosis. J Bone Joint Surg Am 31–A:519–528 PubMed

Gelbke H (1951) The influence of pressure and tension on growing bone in experiments with animals. J Bone Joint Surg Am 33–A:947–954 PubMed

Arkin AM, Katz JF (1956) The effects of pressure on epiphyseal growth; the mechanism of plasticity of growing bone. J Bone Joint Surg Am 38–A:1056–1076 PubMed

Haas SL (1945) Retardation of bone growth by a wire loop. J Bone Joint Surg Am 27:25–36

Haas SL (1948) Mechanical retardation of bone growth. J Bone Joint Surg Am 30–A:506–512 PubMed

Heřt J (1964) Regulation of the longitudinal growth of long bones. (in Czech) Plzeň Lék Sbornik. Suppl 12:1–132

Heřt J (1969) Acceleration of the growth after decrease of load on epiphyseal plates by means of spring distractors. Folia Morphol (Praha) 17:194–203 PubMed