Synergistic effect of folic acid and hypericin administration to improve the efficacy of photodynamic therapy via folate receptors
Jazyk angličtina Země Švýcarsko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
39481178
DOI
10.1016/j.jphotobiol.2024.113046
PII: S1011-1344(24)00206-9
Knihovny.cz E-zdroje
- Klíčová slova
- Folate receptors, Hypericin, Mesoporous silica, Photodynamic therapy, SBA-15, Targeting, Transport,
- MeSH
- anthraceny * MeSH
- folátové receptory zakotvené GPI metabolismus MeSH
- fotochemoterapie * MeSH
- fotosenzibilizující látky * farmakologie chemie MeSH
- hydrofobní a hydrofilní interakce MeSH
- kyselina listová * chemie MeSH
- lidé MeSH
- nádorové buněčné linie MeSH
- nanočástice chemie MeSH
- oxid křemičitý chemie MeSH
- perylen * analogy a deriváty farmakologie chemie MeSH
- singletový kyslík metabolismus MeSH
- synergismus léků * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- anthraceny * MeSH
- folátové receptory zakotvené GPI MeSH
- fotosenzibilizující látky * MeSH
- hypericin MeSH Prohlížeč
- kyselina listová * MeSH
- oxid křemičitý MeSH
- perylen * MeSH
- singletový kyslík MeSH
Transport systems are developed to improve the solubility of the transported drug, increase its stability, enhance its pharmacological activity and target cancer while minimising side effects. In this work, nanoporous silica particles that can be functionalized and loaded with a large number of hydrophobic molecules are proposed. The designed system was modified with folic acid to target the folic acid receptors of cancer cells. This modification enabled a higher uptake of the drug by the cells. Hypericin was selected as a hydrophobic molecule/drug with photodynamic properties suitable for diagnosis and therapy. Fluorescence microscopy and flow cytometry were used to detect the targeting and distribution of hypericin in the cancer cells. Furthermore, the combination of folic acid and hypericin has been shown to form singlet oxygen and to have a synergistic effect in improving the efficacy of photodynamic therapy. The functionalisation of the particles proposed in this work holds great potential for the delivery of hydrophobic drugs to other types of cancer cells with increased expression of the folic acid receptor to which the particles can be attached.
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