The role of an anti-reflux diet in the treatment of chronic cough caused by laryngopharyngeal reflux
Language English Country Germany Media print-electronic
Document type Journal Article, Observational Study
PubMed
39994032
PubMed Central
PMC11950133
DOI
10.1007/s00405-025-09258-3
PII: 10.1007/s00405-025-09258-3
Knihovny.cz E-resources
- Keywords
- Bronchial asthma, Chronic cough, Diet, Laryngopharyngeal reflux, Proton pump inhibitors, Proximal acid exposure time,
- MeSH
- Alginates therapeutic use MeSH
- Chronic Disease MeSH
- Chronic Cough MeSH
- Adult MeSH
- Proton Pump Inhibitors * therapeutic use MeSH
- Cough * etiology diet therapy MeSH
- Laryngopharyngeal Reflux * complications diet therapy MeSH
- Middle Aged MeSH
- Humans MeSH
- Esophageal pH Monitoring MeSH
- Prospective Studies MeSH
- Aged MeSH
- Severity of Illness Index MeSH
- Treatment Outcome MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Observational Study MeSH
- Names of Substances
- Alginates MeSH
- Proton Pump Inhibitors * MeSH
PURPOSE: To evaluate the role of an anti-reflux diet in the treatment of patients with chronic cough caused by laryngopharyngeal reflux (LPR). METHODS: This prospective observational study included patients with chronic cough (lasting over 3 months) and laryngopharyngeal reflux (LPR) confirmed by hypopharyngeal-esophageal 24-h multichannel intraluminal impedance-pH monitoring (HEMII-pH), according to Dubai criteria. Participants were categorized based on cough severity using a visual analog scale (VAS) from 1 to 10. A VAS < 5 was considered to indicate mild cough, whereas a VAS ≥ 5 were considered to indicate severe cough. Patients with mild cough were treated by anti-reflux diet only, while those with severe cough received additional treatment with proton pump inhibitors (PPIs) and alginates. After 3 months, treatment effectiveness was evaluated by assessing the reduction in cough severity. RESULTS: In patients with mild cough, anti-reflux diet alone proved to be effective, yielding improvement in 83.3% of cases. Among patients with severe cough, a combination of anti-reflux diet, proton pump inhibitors (PPIs), and alginates proved was effective in 81.8% of cases. CONCLUSION: Diet alone is an effective and sufficient treatment for mild chronic cough in patients with LPR. For patients with severe chronic cough with LPT, combined anti-reflux measures are effective.
Department of Biomedical Sciences Faculty of Medicine University of Ostrava Ostrava Czech Republic
Department of Craniofacial Surgery Faculty of Medicine University of Ostrava Ostrava Czech Republic
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