Head and neck cancer (HNC) is the sixth most common cancer globally. Incidence and survival rates vary significantly across geographic regions and tumor subsites. This is partly due to differences in risk factor exposure, which includes tobacco smoking, alcohol consumption and human papillomavirus (HPV) infection, alongside detection and treatment strategies. The VOYAGER (human papillomaVirus, Oral and oropharYngeal cAncer GEnomic Research) consortium is a collaboration between five large North American and European studies which generated data on 10,530 participants (7,233 cases and 3,297 controls). The primary goal of the collaboration was to improve understing of the role of HPV and genetic factors in oral cavity and oropharyngeal cancer risk and outcome. Demographic and clinical data collected by the five studies were harmonized, and HPV status was determined for the majority of cases. In addition, 999 tumors were sequenced to define somatic mutations. These activities generated a comprehensive biomedical resource that can be utilized to answer critical outsting research questions to help improve HNC prevention, early detection, treatment, and surveillance.

Bristol Dental School University of Bristol Bristol UK

Cancer Surveillance International Agency for Research on Cancer France

Centro de Investigación Biomédica en Red Epidemiología y Salud Pública Madrid Spain

Computational Biology and Medicine Program Princess Margaret Cancer Centre Toronto Canada

Dalla Lana School of Public Health University of Toronto Toronto Canada

Department of Cardiac Thoracic and Vascular Sciences University of Padova Italy

Department of Epidemiology Gillings School of Global Public Health University of North Carolina US

Department of Human Genetics School of Public Health University of Pittsburgh and UPMC Hillman Cancer Center Pittsburgh US

Department of Medicine University of Tennessee USA

Department of Radiation Oncology Princess Margaret Cancer Centre University Health Network University of Toronto Toronto Canada

Epidemiological Methods and Etiological Research Leibniz Institute for Prevention Research and Epidemiology BIPS Germany

Genomic Epidemiology Group World Health Organization International Agency for Research on Cancer Lyon France

Infections and Cancer Epidemiology German Cancer Research Center Heidelberg Germany

Infections and Cancer Unit Cancer Epidemiology Research Program Catalan Institute of Oncology IDIBELL Barcelona Spain

Institute of Hygiene and Epidemiology Charles University Prague Czech Republic

MRC Integrative Epidemiology Unit Population Health Sciences Bristol Medical School University of Bristol Bristol UK

Nutrition and Cancer Unit Cancer Epidemiology Research Program Catalan Institute of Oncology IDIBELL Barcelona Spain

Prosserman Centre for Population Health Research Lunenfeld Tanenbaum Research Institute Sinai Health System Toronto Canada

Reference Centre for Epidemiology and Cancer Prevention in Piemonte Italy

School of Dental Science Dublin Dental University Hospital Trinity College Dublin Irel

School of Medicine Dentistry and Nursing University of Glasgow UK

School of Medicine Medical Sciences and Nutrition University of Aberdeen UK

School of Medicine National and Kapodistrian University of Athens Greece

School of Public Health University of West Attica Greece

Unit of Cancer Epidemiology Centro di Riferimento Oncologico di Aviano National Cancer Institute IRCCS Italy

University Hospitals Bristol NHS Foundation Trust Bristol Dental Hospital Bristol UK

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