The effect of fecal microbial transplantation in a pediatric patient after 28 episodes of febrile urinary tract infection
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články, kazuistiky
Grantová podpora
VEGA 1/0313/25
Ministerstvo školstva, vedy, výskumu a športu Slovenskej republiky
VEGA 1/0022/26
Ministerstvo školstva, vedy, výskumu a športu Slovenskej republiky
APVV-22-0047
Agentúra Ministerstva Školstva, Vedy, Výskumu a Športu SR
PubMed
40392289
PubMed Central
PMC12402004
DOI
10.1007/s00467-025-06822-1
PII: 10.1007/s00467-025-06822-1
Knihovny.cz E-zdroje
- Klíčová slova
- Chronic kidney disease, Fecal microbial transplantation, Gut microbiome, Metabolome, Recurrent pyelonephritis,
- MeSH
- chronická renální insuficience * etiologie terapie MeSH
- dítě MeSH
- dysbióza terapie mikrobiologie MeSH
- fekální transplantace * metody MeSH
- horečka * terapie etiologie MeSH
- infekce močového ústrojí * terapie mikrobiologie komplikace MeSH
- lidé MeSH
- recidiva MeSH
- střevní mikroflóra MeSH
- výsledek terapie MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
Recurrent febrile urinary tract infections (fUTIs) in children can lead to serious complications such as renal scarring and progressive chronic kidney disease (CKD), with growing evidence indicating that gut microbiome dysbiosis may play a key role in their development. Fecal microbial transplantation (FMT) is an established therapeutic approach for restoring gut microbial balance; however, its use in patients with recurrent fUTIs remains limited and underexplored. This case study describes a 10-year-old boy with recurrent fUTIs and CKD secondary to a posterior urethral valve (PUV) anomaly. The patient was administered a total of seven doses of FMT. FMT reduced pathogenic Enterobacteriaceae, increased beneficial short-chain fatty acid (SCFA)-producing genera, and correspondingly raised SCFA levels, indicating restoration of gut microbiota balance. FMT presents an innovative therapeutic option for pediatric patients with recurrent fUTIs, demonstrating outstanding clinical outcomes.
Children´S Hospital of Philadelphia Philadelphia PA USA
Department of Pediatrics Slovak Medical University in Bratislava Bratislava Slovakia
Department of Pediatrics University of Pennsylvania Philadelphia PA USA
Zobrazit více v PubMed
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