The effect of fecal microbial transplantation in a pediatric patient after 28 episodes of febrile urinary tract infection
Language English Country Germany Media print-electronic
Document type Journal Article, Case Reports
Grant support
VEGA 1/0313/25
Ministerstvo školstva, vedy, výskumu a športu Slovenskej republiky
VEGA 1/0022/26
Ministerstvo školstva, vedy, výskumu a športu Slovenskej republiky
APVV-22-0047
Agentúra Ministerstva Školstva, Vedy, Výskumu a Športu SR
PubMed
40392289
PubMed Central
PMC12402004
DOI
10.1007/s00467-025-06822-1
PII: 10.1007/s00467-025-06822-1
Knihovny.cz E-resources
- Keywords
- Chronic kidney disease, Fecal microbial transplantation, Gut microbiome, Metabolome, Recurrent pyelonephritis,
- MeSH
- Renal Insufficiency, Chronic * etiology therapy MeSH
- Child MeSH
- Dysbiosis therapy microbiology MeSH
- Fecal Microbiota Transplantation * methods MeSH
- Fever * therapy etiology MeSH
- Urinary Tract Infections * therapy microbiology complications MeSH
- Humans MeSH
- Recurrence MeSH
- Gastrointestinal Microbiome MeSH
- Treatment Outcome MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
Recurrent febrile urinary tract infections (fUTIs) in children can lead to serious complications such as renal scarring and progressive chronic kidney disease (CKD), with growing evidence indicating that gut microbiome dysbiosis may play a key role in their development. Fecal microbial transplantation (FMT) is an established therapeutic approach for restoring gut microbial balance; however, its use in patients with recurrent fUTIs remains limited and underexplored. This case study describes a 10-year-old boy with recurrent fUTIs and CKD secondary to a posterior urethral valve (PUV) anomaly. The patient was administered a total of seven doses of FMT. FMT reduced pathogenic Enterobacteriaceae, increased beneficial short-chain fatty acid (SCFA)-producing genera, and correspondingly raised SCFA levels, indicating restoration of gut microbiota balance. FMT presents an innovative therapeutic option for pediatric patients with recurrent fUTIs, demonstrating outstanding clinical outcomes.
Children´S Hospital of Philadelphia Philadelphia PA USA
Department of Pediatrics Slovak Medical University in Bratislava Bratislava Slovakia
Department of Pediatrics University of Pennsylvania Philadelphia PA USA
See more in PubMed
Williams G, Craig JC (2019) Long-term antibiotics for preventing recurrent urinary tract infection in children. Cochrane Database Syst Rev 4:CD001534. 10.1002/14651858.CD001534.pub4 PubMed PMC
Paalanne N, Husso A, Salo J et al (2018) Intestinal microbiome as a risk factor for urinary tract infections in children. Eur J Clin Microbiol Infect Dis 37:1881–1891. 10.1007/s10096-018-3322-7 PubMed
Adamová LM, Slezáková D, Hric I et al (2024) Impact of dance classes on motor and cognitive functions and gut microbiota composition in multiple sclerosis patients: randomized controlled trial. Eur J Sport Sci 24:1186–1196. 10.1002/ejsc.12166 PubMed PMC
Vedrik KEW, de Meij TGJ, Bokenkamp A et al (2022) Transmission of antibiotic-suspectible Escherichia coli causing urinary tract infections in a fecal microbiota transplantation recipient: consequences for donor screening? Open Forum Infect Dis 9:ofac324. 10.1093/ofid/ofac324 PubMed PMC
Lagier JC, Raoult D (2020) Faecal microbiota transplantations and urinary tract infections. Lancet 395:270–271. 10.1016/S0140-6736(19)32992-7 PubMed
