OBJECTIVES: Despite advances in the management of ambulatory paediatric ulcerative colitis (UC), challenges remain as many patients are refractory to therapy and some require colectomy. The aim of these guidelines is to provide an update on optimal care for UC through detailed recommendations and practice points. METHODS: These guidelines are an update to those published in 2018 and are a joint effort of the Paediatric IBD Porto group of European Society of Paediatric Gastroenterology, Hepatology and Nutrition and the European Crohn's and Colitis Organisation. An extensive literature search with subsequent evidence appraisal using the Oxford methodology was performed, followed by three online voting sessions and a consensus face-to-face meeting. Thirty-nine recommendations and 77 practice points were endorsed by the 25 experts with at least an 84% consensus rate. RESULTS: Robust evidence-based recommendations and detailed practice points are provided. In addition to reemphasising and updating the role of more 'traditional' UC therapies, these guidelines outline optimising the use of antitumour necrosis factor therapies and integrating newer biologics and small molecules, as well as supportive therapy, to improve outcomes and provide an updated management algorithm. Measurement and monitoring tools and decision aids are provided, and additional aspects, including nutritional support, extraintestinal manifestations, pouchitis, inflammatory bowel disease-unclassified and patient support, are discussed. Some aspects, including surgery and thromboprophylaxis, are covered in the acute severe UC guidelines. CONCLUSIONS: These guidelines serve as an aid in managing children with UC through a combination of evidence-based recommendations and more practical practice points in the ambulatory setting.

Child Life and Health Centre for Inflammation Research University of Edinburgh Scotland UK

Colorectal Surgery Vall d'Hebron University Hospital Universitat Autònoma de Barcelona UAB Barcelona Spain

Department of Advanced Medical and Surgical Sciences Universitá degli Studi della Campania Luigi Vanvitelli Naples Italy

Department of Medicine Solna Division of Clinical Epidemiology Karolinska Institutet Stockholm Sweden

Department of Paediatric Gastroenterology Erasmus MC Sophia Children's Hospital Rotterdam The Netherlands

Department of Paediatric Gastroenterology Hepatology and Nutrition University Medical Center Groningen University of Groningen Groningen the Netherlands

Department of Paediatric Gastroenterology Jenny Lind Children's Hospital Norfolk and Norwich University Hospitals Faculty of Medicine and Health Science University of East Anglia Norwich UK

Department of Paediatric Gastroenterology Royal Hospital for Children and Young People Edinburgh Scotland UK

Department of Paediatrics University Hospital Motol Prague Czech Republic

Department of Paediatrics Vittore Buzzi Children's Hospital University of Milan Milan Italy

Department of Pediatric Gastroenterology Hepatology and Nutrition Hospital Sant Joan de Déu Barcelona Spain

Department of Pediatrics Children's Hospital Zagreb University of Zagreb Medical School Referral Center for Pediatric Gastroenterology and Nutrition Zagreb Croatia

Department of Pediatrics Division of Pediatric Gastroenterology University of Alberta Edmonton Alberta Canada

Division of Gastroenterology Hepatology and Nutrition The Hospital for Sick Children Toronto Ontario Canada

Division of Paediatric Gastroenterology and Nutrition Emma Children's Hospital Amsterdam UMC Amsterdam The Netherlands

DOCHAS Group Children's Health Ireland University College Dublin Dublin Ireland

Faculty of Medical and Health Sciences Tel Aviv University Tel Aviv Israel

Faculty of Medicine Tel Aviv University Tel Aviv Israel

Pediatric Gastroenterology and Nutrition Unit Centro Hospitalar Universitário São João Porto Portugal

Pediatric Gastroenterology Ghent University hospital Ghent Belgium

Pediatric Gastroenterology Hepatology and Cystic Fibrosis Unit Department of Pathophysiology and Transplantation University of Milan Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico di Milano Milan Italy

Pediatric Gastroenterology Institute Dana Dwek Children's Hospital Tel Aviv Sourasky Medical Center Tel Aviv Israel

Schneider Children's Medical Center of Israel Institute of Gastroenterology Nutrition and Liver Diseases Petah Tikva Israel

Section of Paediatrics Department of Translational Medical Science University of Naples Federico 2 Naples Italy

Shaare Zedek Medical Centre The Juliet Keidan Institute of Paediatric Gastroenterology and Nutrition Eisenberg R and D Authority The Hebrew University Jerusalem Israel

Translational Gastroenterology Unit John Radcliffe Hospital Oxford University Hospitals NHS Trust Oxford UK

University of Toronto Toronto Ontario Canada

See more in PubMed

Weidner J, Kern I, Reinecke I, et al. A systematic review and meta‐regression on international trends in the incidence of ulcerative colitis in children and adolescents associated with socioeconomic and geographic factors. Eur J Pediatr. 2024;183(4):1723‐1732. PubMed PMC

Ng SC, Shi HY, Hamidi N, et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population‐based studies. Lancet. 2017;390(10114):2769‐2778. PubMed

Dorn‐Rasmussen M, Lo B, Zhao M, et al. The incidence and prevalence of paediatric‐ and adult‐onset inflammatory bowel disease in Denmark during a 37‐year period: a nationwide cohort study (1980‐2017). J Crohns Colitis. 2023;17(2):259‐268. PubMed

Kuenzig ME, Fung SG, Marderfeld L, et al. Twenty‐first century trends in the global epidemiology of pediatric‐onset inflammatory bowel disease: systematic review. Gastroenterology. 2022;162(4):1147‐1159.e4. PubMed

Vekara L, Kantanen S, Kolho KL, et al. Psychological well‐being of children and adolescents with inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2024;78(6):1287‐1296. PubMed

El‐Matary W, Carroll MW, Deslandres C, et al. The 2023 impact of inflammatory bowel disease in Canada: special populations‐children and adolescents with IBD. J Can Assoc Gastroenterol. 2023;6(suppl 2):S35‐S44. PubMed PMC

Herzog D, Fournier N, Buehr P, et al. Prevalence of intestinal complications in inflammatory bowel disease: a comparison between paediatric‐onset and adult‐onset patients. Eur J Gastroenterol Hepatol. 2017;29(8):926‐931. PubMed

Kim JY, Park DI, Han DS, et al. Comparing the clinical outcomes of young‐onset and adult‐onset ulcerative colitis: a multi‐center Korean association for the study for intestinal diseases study. Korean J Intern Med. 2017;32(1):69‐78. PubMed PMC

Raine T, Bonovas S, Burisch J, et al. ECCO guidelines on therapeutics in ulcerative colitis: medical treatment. J Crohns Colitis. 2022;16(1):2‐17. PubMed

Wine E, deBruyn J, Crowley E, et al. Response from the Canadian children inflammatory bowel disease network to the US Food and Drug Administration draft guidance for industry on pediatric inflammatory bowel disease: developing drugs for treatment. J Can Assoc Gastroenterol. 2024;7:397‐398. PubMed PMC

Hyams JS, Winter HS, Mulberg AE, et al. An open letter to the Food and Drug Administration and pharmaceutical industry concerning drug approval for children with inflammatory bowel disease. Inflamm Bowel Dis. 2024;30(12):2523‐2525. PubMed

Turner D, Russell RK, Wine E, et al. Response to FDA draft guidance on pediatric IBD drug approval trials: a consensus statement from the IBD Porto group. J Pediatr Gastroenterol Nutr. 2025;80(1):238‐241. PubMed

Turner D, Ruemmele FM, Orlanski‐Meyer E, et al. Management of paediatric ulcerative colitis, part 1: ambulatory care—an evidence‐based guideline from European Crohn's and Colitis Organization and European Society of Paediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr. 2018;67(2):257‐291. PubMed

Turner D, Levine A, Escher JC, et al. Management of pediatric ulcerative colitis: joint ECCO and ESPGHAN evidence‐based consensus guidelines. J Pediatr Gastroenterol Nutr. 2012;55(3):340‐361. PubMed

Assa A, Aloi M, Van Biervliet S, et al. Management of paediatric ulcerative colitis, part 2: Acute severe colitis‐An updated evidence‐based consensus guideline from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition and the European Crohn's and Colitis Organization. J Pediatr Gastroenterol Nutr. Published online June 17, 2025. 10.1002/jpn3.70096 PubMed DOI

Levine A, Koletzko S, Turner D, et al. ESPGHAN revised Porto criteria for the diagnosis of inflammatory bowel disease in children and adolescents. J Pediatr Gastroenterol Nutr. 2014;58(6):795‐806. PubMed

Birimberg‐Schwartz L, Zucker DM, Akriv A, et al. Development and validation of diagnostic criteria for IBD subtypes including IBD‐unclassified in children: a multicentre study from the pediatric IBD Porto group of ESPGHAN. J Crohns Colitis. 2017;11(9):1078‐1084. PubMed

Uhlig HH, Charbit‐Henrion F, Kotlarz D, et al. Clinical genomics for the diagnosis of monogenic forms of inflammatory bowel disease: a position paper from the paediatric IBD Porto group of European Society of Paediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr. 2021;72(3):456‐473. PubMed PMC

Ouahed J, Spencer E, Kotlarz D, et al. Very early onset inflammatory bowel disease: a clinical approach with a focus on the role of genetics and underlying immune deficiencies. Inflamm Bowel Dis. 2020;26(6):820‐842. PubMed PMC

Tringali A, Thomson M, Dumonceau JM, et al. Pediatric gastrointestinal endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) and European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) guideline executive summary. Endoscopy. 2017;49(1):83‐91. PubMed

Amil‐Dias J, Kolacek S, Turner D, et al. Surgical management of Crohn disease in children: guidelines from the Paediatric IBD Porto group of ESPGHAN. J Pediatr Gastroenterol Nutr. 2017;64(5):818‐835. PubMed

van Rheenen PF, Kolho KL, Russell RK, et al. Primary sclerosing cholangitis in children with inflammatory bowel disease: an ESPGHAN position paper from the hepatology committee and the IBD Porto group. J Pediatr Gastroenterol Nutr. 2025;80(2):374‐393. PubMed PMC

Wells GA, Shea B, O'Connell D, et al. The Newcastle‐Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta‐analyses; 2013. http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp

Higgins JPT, Green S, eds. Cochrane handbook for systematic reviews of interventions. In: The Cochrane Library. John Wiley & Sons Ltd.; 2011. www.cochrane-handbook.org

OCEBM Levels of Evidence Working Group .

Turner D, Ricciuto A, Lewis A, et al. STRIDE‐II: an update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) initiative of the International Organization to Study IBD (IOIBD): determining therapeutic goals for treat‐to‐target strategies in IBD. Gastroenterology. 2021;160(5):1570‐1583. PubMed

Turner D, Griffiths AM, Veerman G, et al. Endoscopic and clinical variables that predict sustained remission in children with ulcerative colitis treated with infliximab. Clin Gastroenterol Hepatol. 2013;11(11):1460‐1465. PubMed

Turner D, Seow CH, Greenberg GR, Griffiths AM, Silverberg MS, Steinhart AH. A systematic prospective comparison of noninvasive disease activity indices in ulcerative colitis. Clin Gastroenterol Hepatol. 2009;7(10):1081‐1088. PubMed

Turner D, Otley AR, Mack D, et al. Development, validation, and evaluation of a pediatric ulcerative colitis activity index: a prospective multicenter study. Gastroenterology. 2007;133(2):423‐432. PubMed

Sarbagili‐Shabat C, Weiner D, Wardi J, Abramas L, Yaakov M, Levine A. Moderate‐to‐severe endoscopic inflammation is frequent after clinical remission in pediatric ulcerative colitis. J Pediatr Gastroenterol Nutr. 2021;72(4):569‐573. PubMed

Kerur B, Litman HJ, Stern JB, et al. Correlation of endoscopic disease severity with pediatric ulcerative colitis activity index score in children and young adults with ulcerative colitis. World J Gastroenterol. 2017;23(18):3322‐3329. PubMed PMC

Ricciuto A, Fish J, Carman N, et al. Symptoms do not correlate with findings from colonoscopy in children with inflammatory bowel disease and primary sclerosing cholangitis. Clin Gastroenterol Hepatol. 2018;16(7):1098‐1105.e1. PubMed

Hyams JS, Davis S, Mack DR, et al. Factors associated with early outcomes following standardised therapy in children with ulcerative colitis (PROTECT): a multicentre inception cohort study. Lancet Gastroenterol Hepatol. 2017;2(12):855‐868. PubMed PMC

Hyams JS, Davis Thomas S, Gotman N, et al. Clinical and biological predictors of response to standardised paediatric colitis therapy (PROTECT): a multicentre inception cohort study. Lancet. 2019;393(10182):1708‐1720. PubMed PMC

Hyams JS, Brimacombe M, Haberman Y, et al. Clinical and host biological factors predict colectomy risk in children newly diagnosed with ulcerative colitis. Inflamm Bowel Dis. 2022;28(2):151‐160. PubMed PMC

Atia O, Klomberg RCW, de Ridder L, et al. Validation of predictive models for disease outcomes in paediatric ulcerative colitis: a multicentre prospective inception cohort. Aliment Pharmacol Ther. 2023;58(2):182‐190. PubMed

Rinawi F, Assa A, Eliakim R, et al. Risk of colectomy in patients with pediatric‐onset ulcerative colitis. J Pediatr Gastroenterol Nutr. 2017;65(4):410‐415. PubMed

Jang J, Lee SH, Jeong IS, et al. Clinical characteristics and long‐term outcomes of pediatric ulcerative colitis: a single‐center experience in Korea. Gut Liver. 2022;16(2):236‐245. PubMed PMC

Assa A, Rinawi F, Shamir R. The long‐term predictive properties of the Paris classification in paediatric inflammatory bowel disease patients. J Crohns Colitis. 2018;12(1):39‐47. PubMed

Aniwan S, Bruining DH, Park SH, et al. The combination of patient‐reported clinical symptoms and an endoscopic score correlates well with health‐related quality of life in patients with ulcerative colitis. J Clin Med. 2019;8(8):1171. PubMed PMC

Peyrin‐Biroulet L, Van Assche G, Sturm A, et al. Treatment satisfaction, preferences and perception gaps between patients and physicians in the ulcerative colitis CARES study: a real world‐based study. Dig Liver Dis. 2016;48(6):601‐607. PubMed

Marcovitch L, Focht G, Carmon N, et al. Development and validation of the TUMMY‐UC: a patient‐reported outcome for pediatric ulcerative colitis. Gastroenterology. 2023;164(4):610‐618.e4. PubMed

Crawford E, Gestrich C, Malay S, et al. Association of fecal calprotectin with endoscopic and histologic activity in pediatric inflammatory bowel disease. JPGN Rep. 2021;2(4):e129. PubMed PMC

Singh S, Ananthakrishnan AN, Nguyen NH, et al. AGA clinical practice guideline on the role of biomarkers for the management of ulcerative colitis. Gastroenterology. 2023;164(3):344‐372. PubMed

Plevris N, Lees CW. Disease monitoring in inflammatory bowel disease: evolving principles and possibilities. Gastroenterology. 2022;162(5):1456‐1475.e1. PubMed

Diederen K, Hoekman DR, Leek A, et al. Raised faecal calprotectin is associated with subsequent symptomatic relapse, in children and adolescents with inflammatory bowel disease in clinical remission. Aliment Pharmacol Ther. 2017;45(7):951‐960. PubMed

Krishnakumar C, Ananthakrishnan AN, Boyle BM, et al. Early change in fecal calprotectin predicts one‐year outcome in children newly diagnosed with ulcerative colitis. J Pediatr Gastroenterol Nutr. 2022;74(1):72‐78. PubMed

Tsampalieros A, Griffiths AM, Barrowman N, Mack DR. Use of C‐reactive protein in children with newly diagnosed inflammatory bowel disease. J Pediatr. 2011;159(2):340‐342. PubMed

Clough J, Colwill M, Poullis A, Pollok R, Patel K, Honap S. Biomarkers in inflammatory bowel disease: a practical guide. Therap Adv Gastroenterol. 2024;17:17562848241251600. PubMed PMC

Deva Rajoo G, Tan L, Lopez A, Lewindon P, Grover Z. Early response to corticosteroid and baseline C‐reactive protein predicts outcomes in children with moderate to severe ulcerative colitis. Dig Dis Sci. 2019;64(7):1929‐1937. PubMed

Ziade F, Rungoe C, Kallemose T, Paerregaard A, Wewer AV, Jakobsen C. Biochemical markers, genotype, and inflammation in pediatric inflammatory bowel disease: a Danish population‐based study. Dig Dis. 2019;37(2):140‐146. PubMed

Benchimol EI, Tse F, Carroll MW, et al. Canadian association of gastroenterology clinical practice guideline for immunizations in patients with inflammatory bowel disease (IBD)—part 1: live vaccines. Gastroenterology. 2021;161(2):669‐680.e0. PubMed

Jones JL, Tse F, Carroll MW, et al. Canadian association of gastroenterology clinical practice guideline for immunizations In patients with inflammatory bowel disease (IBD)—part 2: inactivated vaccines. Gastroenterology. 2021;161(2):681‐700. PubMed

Oliva S, Thomson M, de Ridder L, et al. Endoscopy in pediatric inflammatory bowel disease: a position paper on behalf of the Porto IBD group of the European Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr. 2018;67(3):414‐430. PubMed

Lobatón T, Bessissow T, De Hertogh G, et al. The modified Mayo Endoscopic Score (MMES): a new index for the assessment of extension and severity of endoscopic activity in ulcerative colitis patients. J Crohns Colitis. 2015;9(10):846‐852. PubMed

Travis SPL, Schnell D, Krzeski P, et al. Developing an instrument to assess the endoscopic severity of ulcerative colitis: the ulcerative colitis endoscopic index of severity (UCEIS). Gut. 2012;61(4):535‐542. PubMed PMC

Scarallo L, Peruggia E, Fioretti L, et al. Long‐term outcome of ulcerative colitis in pediatric patients who achieved mucosal and histological healing: a real‐life referral center experience. J Pediatr Gastroenterol Nutr. 2022;74(2):590.

Gupta A, Yu A, Peyrin‐Biroulet L, Ananthakrishnan AN. Treat to target: the role of histologic healing in inflammatory bowel diseases: a systematic review and meta‐analysis. Clin Gastroenterol Hepatol. 2021;19(9):1800‐1813.e4. PubMed

Stenke E, Stallard L, Cooper S, et al. Mucosal atrophy predicts poorer outcomes in pediatric ulcerative colitis—a national inception cohort study. J Pediatr Gastroenterol Nutr. 2023;76(5):603‐609. PubMed

Green N, Lee D, Wahbeh G, Pacheco MC. Do histologic features help predict colectomy in pediatric patients presenting with acute severe colitis? Pediatr Dev Pathol. 2020;23(5):380‐386. PubMed

Catassi G, Tittarelli S, Veraldi S, et al. Histologic findings at diagnosis as predictive markers of clinical outcome in pediatric ulcerative colitis. Dig Liver Dis. 2024;56(1):106‐111. PubMed

Clarkston K, Karns R, Jegga AG, et al. Targeted assessment of mucosal immune gene expression predicts clinical outcomes in children with ulcerative colitis. J Crohns Colitis. 2022;16(11):1735‐1750. PubMed PMC

Jabandziev P, Kakisaka T, Bohosova J, et al. MicroRNAs in colon tissue of pediatric ulcerative pancolitis patients allow detection and prognostic stratification. J Clin Med. 2021;10(6):1325. PubMed PMC

Pereira MS, Maia L, Azevedo LF, et al. A [Glyco]biomarker that predicts failure to standard therapy in ulcerative colitis patients. J Crohns Colitis. 2019;13(1):39‐49. PubMed

Wedrychowicz A, Tomasik P, Zajac A, et al. Prognostic value of assessment of stool and serum IL‐1beta, IL‐1ra and IL‐6 concentrations in children with active and inactive ulcerative colitis. Arch Med Sci. 2018;14(1):107‐114. PubMed PMC

de Voogd F, van Wassenaer EA, Mookhoek A, et al. Intestinal ultrasound is accurate to determine endoscopic response and remission in patients with moderate to severe ulcerative colitis: a longitudinal prospective cohort study. Gastroenterology. 2022;163(6):1569‐1581. PubMed

van Wassenaer EA, de Voogd FAE, van Rijn RR, et al. Bowel ultrasound measurements in healthy children – systematic review and meta‐analysis. Pediatr Radiol. 2020;50(4):501‐508. PubMed PMC

van Wassenaer EA, de Voogd FAE, van Rijn RR, et al. Diagnostic accuracy of transabdominal ultrasound in detecting intestinal inflammation in paediatric IBD patients—a systematic review. J Crohns Colitis. 2019;13(12):1501‐1509. PubMed PMC

van Wassenaer EA, van Rijn RR, Zwetsloot SLM, et al. Intestinal ultrasound to assess ulcerative colitis disease activity in children: external validation and comparison of 2 intestinal ultrasound activity indices. Inflamm Bowel Dis. 2023;29(8):1217‐1222. PubMed PMC

Gordon H, Biancone L, Fiorino G, et al. ECCO guidelines on inflammatory bowel disease and malignancies. J Crohns Colitis. 2023;17(6):827‐854. PubMed

Annese V, Daperno M, Rutter MD, et al. European evidence based consensus for endoscopy in inflammatory bowel disease. J Crohns Colitis. 2013;7(12):982‐1018. PubMed

Olén O, Askling J, Sachs M, et al. Childhood onset inflammatory bowel disease and risk of cancer: a Swedish nationwide cohort study 1964‐2014. BMJ. 2017;358:j3951. PubMed PMC

Everhov ÅH, Ludvigsson JF, Järås J, et al. Colorectal cancer in childhood‐onset inflammatory bowel disease: a Scandinavian register‐based cohort study, 1969‐2017. J Pediatr Gastroenterol Nutr. 2022;75(4):480‐484. PubMed

de Ridder L, Turner D, Wilson DC, et al. Malignancy and mortality in pediatric patients with inflammatory bowel disease: a multinational study from the Porto Pediatric IBD group. Inflamm Bowel Dis. 2014;20(2):291‐300. PubMed

Lindberg J, Stenling R, Palmqvist R, Rutegård J. Early onset of ulcerative colitis: long‐term follow‐up with special reference to colorectal cancer and primary sclerosing cholangitis. J Pediatr Gastroenterol Nutr. 2008;46(5):534‐538. PubMed

Joosse ME, Aardoom MA, Kemos P, et al. Malignancy and mortality in paediatric‐onset inflammatory bowel disease: a 3‐year prospective, multinational study from the paediatric IBD Porto group of ESPGHAN. Aliment Pharmacol Ther. 2018;48(5):523‐537. PubMed

Murray A, Nguyen TM, Parker CE, et al. Oral 5‐aminosalicylic acid for induction of remission in ulcerative colitis. Cochrane Database Syst Rev. 2020;8:CD000543. PubMed PMC

Murray A, Nguyen TM, Parker CE, et al. Oral 5‐aminosalicylic acid for maintenance of remission in ulcerative colitis. Cochrane Database Syst Rev. 2020;8:CD000544. PubMed PMC

Ferry GD, Kirschner BS, Grand RJ, et al. Olsalazine versus sulfasalazine in mild to moderate childhood ulcerative colitis: results of the pediatric gastroenterology collaborative research group clinical trial. J Pediatr Gastroenterol Nutr. 1993;17(1):32‐38. PubMed

Romano C, Famiani A, Comito D, Rossi P, Raffa V, Fries W. Oral beclomethasone dipropionate in pediatric active ulcerative colitis: a comparison trial with mesalazine. J Pediatr Gastroenterol Nutr. 2010;50(4):385‐389. PubMed

Quiros JA, Heyman MB, Pohl JF, et al. Safety, efficacy, and pharmacokinetics of balsalazide in pediatric patients with mild‐to‐moderate active ulcerative colitis: results of a randomized, double‐blind study. J Pediatr Gastroenterol Nutr. 2009;49(5):571‐579. PubMed PMC

Croft NM, Korczowski B, Kierkuś J, Caballero B, Thakur MK. Safety and efficacy of multimatrix mesalamine in paediatric patients with mild‐to‐moderate ulcerative colitis: a phase 3, randomised, double‐blind study. EClinicalMedicine. 2023;65:102232. PubMed PMC

Winter HS, Krzeski P, Heyman MB, et al. High‐ and low‐dose oral delayed‐release mesalamine in children with mild‐to‐moderately active ulcerative colitis. J Pediatr Gastroenterol Nutr. 2014;59(6):767‐772. PubMed PMC

Turner D, Yerushalmi B, Kori M, et al. Once‐ versus twice‐daily mesalazine to induce remission in paediatric ulcerative colitis: a randomised controlled trial. J Crohns Colitis. 2017;11(5):527‐533. PubMed

Zeisler B, Lerer T, Markowitz J, et al. Outcome following aminosalicylate therapy in children newly diagnosed as having ulcerative colitis. J Pediatr Gastroenterol Nutr. 2013;56(1):12‐18. PubMed

Aloi M, Bramuzzo M, Norsa L, et al. Disease activity patterns in the first 5 years after diagnosis in children with ulcerative colitis: a population‐based study. J Crohns Colitis. 2021;15(3):367‐374. PubMed

Nikfar S, Rahimi R, Rezaie A, Abdollahi M. A meta‐analysis of the efficacy of sulfasalazine in comparison with 5‐aminosalicylates in the induction of improvement and maintenance of remission in patients with ulcerative colitis. Dig Dis Sci. 2009;54(6):1157‐1170. PubMed

Cuffari C, Pierce D, Korczowski B, et al. Randomized clinical trial: pharmacokinetics and safety of multimatrix mesalamine for treatment of pediatric ulcerative colitis. Drug Des Devel Ther. 2016;10:593‐607. PubMed PMC

Christensen LA, Fallingborg J, Jacobsen BA, et al. Bioavailability of 5‐aminosalicylic acid from slow release 5‐aminosalicylic acid drug and sulfasalazine in normal children. Dig Dis Sci. 1993;38(10):1831‐1836. PubMed

Wiersma H, Escher JC, Dilger K, et al. Pharmacokinetics of mesalazine pellets in children with inflammatory bowel disease. Inflamm Bowel Dis. 2004;10(5):626‐631. PubMed

Sandborn WJ, Regula J, Feagan BG, et al. Delayed‐release oral mesalamine 4.8 g/day (800‐mg tablet) is effective for patients with moderately active ulcerative colitis. Gastroenterology. 2009;137(6):1934‐1943.e3. PubMed

Lichtenstein GR, Ramsey D, Rubin DT. Randomised clinical trial: delayed‐release oral mesalazine 4.8 g/day vs. 2.4 g/day in endoscopic mucosal healing—ASCEND I and II combined analysis. Aliment Pharmacol Ther. 2011;33(6):672‐678. PubMed

Van Limbergen J, Russell RK, Drummond HE, et al. Definition of phenotypic characteristics of childhood‐onset inflammatory bowel disease. Gastroenterology. 2008;135(4):1114‐1122. PubMed

Wahl C, Liptay S, Adler G, Schmid RM. Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B. J Clin Invest. 1998;101(5):1163‐1174. PubMed PMC

Mansuri I, Wang S, Rufo PA, Liu E, Chan C, Bousvaros A. Efficacy and safety of sulfasalazine suspension in children with ulcerative colitis. J Pediatr Gastroenterol Nutr. 2023;76(4):460‐467. PubMed

Buurman DJ, De Monchy JGR, Schellekens RCA, van der Waaij LA, Kleibeuker JH, Dijkstra G. Ulcerative colitis patients with an inflammatory response upon mesalazine cannot be desensitized: a randomized study. Scand J Gastroenterol. 2015;50(4):399‐405. PubMed

Heap GA, So K, Weedon M, et al. Clinical features and HLA association of 5‐aminosalicylate (5‐ASA)‐induced nephrotoxicity in inflammatory bowel disease. J Crohns Colitis. 2016;10(2):149‐158. PubMed

Co ML, Gorospe EC. Pediatric case of mesalazine‐induced interstitial nephritis with literature review. Pediatr Int. 2013;55(3):385‐387. PubMed

van Hoeve K, Hoffman I. Renal manifestations in inflammatory bowel disease: a systematic review. J Gastroenterol. 2022;57(9):619‐629. PubMed

Kohli R, Melin‐Aldana H, Sentongo TA. Mesalamine‐induced pneumonitis during therapy for chronic inflammatory bowel disease: a pediatric case report. J Pediatr Gastroenterol Nutr. 2005;41(4):479‐482. PubMed

Sentongo TAS, Piccoli DA. Recurrent pericarditis due to mesalamine hypersensitivity: a pediatric case report and review of the literature. J Pediatr Gastroenterol Nutr. 1998;27(3):344‐347. PubMed

Rosenbaum J, Alex G, Roberts H, Orchard D. Drug rash with eosinophilia and systemic symptoms secondary to sulfasalazine. J Paediatr Child Health. 2010;46(4):193‐196. PubMed

Ratajczak AE, Szymczak‐Tomczak A, Rychter AM, Zawada A, Dobrowolska A, Krela‐Kaźmierczak I. Does folic acid protect patients with inflammatory bowel disease from complications? Nutrients. 2021;13(11):4036. PubMed PMC

Iofel E, Chawla A, Daum F, Markowitz J. Mesalamine intolerance mimics symptoms of active inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2002;34(1):73‐76. PubMed

Carmody JK, Plevinsky J, Peugh JL, et al. Longitudinal non‐adherence predicts treatment escalation in paediatric ulcerative colitis. Aliment Pharmacol Ther. 2019;50(8):911‐918. PubMed PMC

Atia O, Magen Rimon R, Ledderman N, et al. Prevalence and outcomes of no treatment versus 5‐ASA in ulcerative colitis: a nationwide analysis from the epi‐IIRN. Inflamm Bowel Dis. 2024;30(2):213‐221. PubMed

Bonovas S, Fiorino G, Lytras T, Nikolopoulos G, Peyrin‐Biroulet L, Danese S. Systematic review with meta‐analysis: use of 5‐aminosalicylates and risk of colorectal neoplasia in patients with inflammatory bowel disease. Aliment Pharmacol Ther. 2017;45(9):1179‐1192. PubMed

Chapman TP, Frias Gomes C, Louis E, Colombel JF, Satsangi J. Review article: withdrawal of 5‐aminosalicylates in inflammatory bowel disease. Aliment Pharmacol Ther. 2020;52(1):73‐84. PubMed

Tal‐Shifman N, Tzivinikos C, Gasparetto M, et al. P150 identification of features associated with poor outcomes in pediatric patients with ulcerative proctitis: a multicentre study from the paediatric IBD Porto group of ESPGHAN. J Crohns Colitis. 2023;17:i309‐i311. PubMed

Hochart A, Gower‐Rousseau C, Sarter H, et al. Ulcerative proctitis is a frequent location of paediatric‐onset UC and not a minor disease: a population‐based study. Gut. 2017;66(11):1912‐1917. PubMed

Martinelli M, Fedele F, Romano C, et al. Disease course of ulcerative proctitis in children: a population‐based study on behalf of the SIGENP IBD group. Dig Liver Dis. 2024;56(1):70‐76. PubMed

Sokollik C, Fournier N, Rizzuti D, et al. The use of 5‐aminosalicylic acid in children and adolescents with inflammatory bowel disease. J Clin Gastroenterol. 2018;52(10):e87‐e91. PubMed

Heyman MB, Kierkus J, Spénard J, Shbaklo H, Giguere M. Efficacy and safety of mesalamine suppositories for treatment of ulcerative proctitis in children and adolescents. Inflamm Bowel Dis. 2010;16(11):1931‐1939. PubMed PMC

Marteau P. Combined oral and enema treatment with pentasa (mesalazine) is superior to oral therapy alone in patients with extensive mild/moderate active ulcerative colitis: a randomised, double blind, placebo controlled study. Gut. 2005;54(7):960‐965. PubMed PMC

Probert CSJ, Dignass AU, Lindgren S, Oudkerk Pool M, Marteau P. Combined oral and rectal mesalazine for the treatment of mild‐to‐moderately active ulcerative colitis: rapid symptom resolution and improvements in quality of life. J Crohns Colitis. 2014;8(3):200‐207. PubMed

Levine A, Yerushalmi B, Kori M, et al. Mesalamine enemas for induction of remission in oral mesalamine‐refractory pediatric ulcerative colitis: a prospective cohort study. J Crohns Colitis. 2017;11(8):970‐974. PubMed

Marshall JK, Thabane M, Steinhart AH, et al. Rectal 5‐aminosalicylic acid for induction of remission in ulcerative colitis. Cochrane Database Syst Rev. 2010:CD004115. 10.1002/14651858.CD004115.pub2 PubMed DOI

Marshall JK, Thabane M, Steinhart AH, et al. Rectal 5‐aminosalicylic acid for maintenance of remission in ulcerative colitis. Cochrane Database Syst Rev. 2012;11:CD004118. PubMed PMC

Cohen RD, Dalal SR. Systematic review: rectal therapies for the treatment of distal forms of ulcerative colitis. Inflamm Bowel Dis. 2015;21(7):1719‐1736. PubMed

Watanabe M, Nishino H, Sameshima Y, Ota A, Nakamura S, Hibi T. Randomised clinical trial: evaluation of the efficacy of mesalazine (mesalamine) suppositories in patients with ulcerative colitis and active rectal inflammation—a placebo‐controlled study. Aliment Pharmacol Ther. 2013;38(3):264‐273. PubMed

Lamet M. A multicenter, randomized study to evaluate the efficacy and safety of mesalamine suppositories 1 g at bedtime and 500 mg twice daily in patients with active mild‐to‐moderate ulcerative proctitis. Dig Dis Sci. 2011;56(2):513‐522. PubMed PMC

Kruis W, Siegmund B, Lesniakowski K, et al. Novel budesonide suppository and standard budesonide rectal foam induce high rates of clinical remission and mucosal healing in active ulcerative proctitis, a randomised, controlled, non‐inferiority trial. J Crohns Colitis. 2022;16(11):1714‐1724. PubMed PMC

Lawrance IC, Copeland TS. Rectal tacrolimus in the treatment of resistant ulcerative proctitis. Aliment Pharmacol Ther. 2008;28(10):1214‐1220. PubMed

Lee CH, Tasker N, La Hei E, Dutt S. Raised tacrolimus level and acute renal injury associated with acute gastroenteritis in a child receiving local rectal tacrolimus. Clin J Gastroenterol. 2014;7(3):238‐242. PubMed

Lawrance IC, Baird A, Lightower D, Radford‐Smith G, Andrews JM, Connor S. Efficacy of rectal tacrolimus for induction therapy in patients with resistant ulcerative proctitis. Clin Gastroenterol Hepatol. 2017;15(8):1248‐1255. PubMed

Cakir M, Ozgenc F, Yusekkaya HA, Ecevit CO, Yagci RV. Steroid response in moderate to severe pediatric ulcerative colitis: a single center's experience. World J Pediatr. 2011;7(1):50‐53. PubMed

Hyams J, Markowitz J, Lerer T, et al. The natural history of corticosteroid therapy for ulcerative colitis in children. Clin Gastroenterol Hepatol. 2006;4(9):1118‐1123. PubMed

Martinelli M, Giugliano FP, Russo M, et al. The changing face of pediatric ulcerative colitis: a population‐based cohort study. J Pediatr Gastroenterol Nutr. 2018;66(6):903‐908. PubMed

Tung J, Loftus, Jr. EV , Freese DK, et al. A population‐based study of the frequency of corticosteroid resistance and dependence in pediatric patients with Crohn's disease and ulcerative colitis. Inflamm Bowel Dis. 2006;12(12):1093‐1100. PubMed

Gower‐Rousseau C, Dauchet L, Vernier‐Massouille G, et al. The natural history of pediatric ulcerative colitis: a population‐based cohort study. Am J Gastroenterol. 2009;104(8):2080‐2088. PubMed

Jakobsen C, Bartek, Jr. J , Wewer V, et al. Differences in phenotype and disease course in adult and paediatric inflammatory bowel disease—a population‐based study. Aliment Pharmacol Ther. 2011;34(10):1217‐1224. PubMed

Harris RE, Sim W, Sutton H, et al. Using a steroid‐sparing tool in paediatric inflammatory bowel disease to evaluate steroid use and dependency. J Pediatr Gastroenterol Nutr. 2019;69(5):557‐563. PubMed

Beattie RM, Nicholls SW, Domizio P, et al. Endoscopic assessment of the colonic response to corticosteroids in children with ulcerative colitis. J Pediatr Gastroenterol Nutr. 1996;22(4):373‐379. PubMed

Cucinotta U, Arrigo S, Dipasquale V, et al. Clinical course of very early‐onset inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2023;76(5):590‐595. PubMed

Barberio B, Marsilio I, Buda A, et al. Efficacy and safety of oral beclomethasone dipropionate and budesonide MMX versus 5‐aminosalicylates or placebo in ulcerative colitis: a systematic review and meta‐analysis. Therap Adv Gastroenterol. 2023;16:17562848231188549. PubMed PMC

Rimsza ME. Complications of corticosteroid therapy. Arch Pediatr Adolesc Med. 1978;132(8):806‐810. PubMed

Liu D, Ahmet A, Ward L, et al. A practical guide to the monitoring and management of the complications of systemic corticosteroid therapy. Allergy Asthma Clin Immunol. 2013;9(1):30. PubMed PMC

Kaye LD, Kalenak JW, Price RL, Cunningham R. Ocular implications of long‐term prednisone therapy in children. J Pediatr Ophthalmol Strabismus. 1993;30(3):142‐144. PubMed

Akahoshi S, Hasegawa Y. Steroid‐induced iatrogenic adrenal insufficiency in children: a literature review. Endocrines. 2020;1(2):125‐137.

Younes AK, Younes NK. Recovery of steroid induced adrenal insufficiency. Transl Pediatr. 2017;6(4):269‐273. PubMed PMC

Hahner S, Ross RJ, Arlt W, et al. Adrenal insufficiency. Nat Rev Dis Primers. 2021;7(1):19. PubMed

Fleseriu M, Hashim IA, Karavitaki N, et al. Hormonal replacement in hypopituitarism in adults: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2016;101(11):3888‐3921. PubMed

Linder BL, Esteban NV, Yergey AL, Winterer JC, Loriaux DL, Cassorla F. Cortisol production rate in childhood and adolescence. J Pediatr. 1990;117(6):892‐896. PubMed

Esteban NV, Yergey AL. Cortisol production rates measured by liquid chromatography/mass spectrometry. Steroids. 1990;55(4):152‐158. PubMed

Kerrigan JR, Kerrigan JR, Veldhuis JD, Leyo SA, Iranmanesh A, Rogol AD. Estimation of daily cortisol production and clearance rates in normal pubertal males by deconvolution analysis. J Clin Endocrinol Metab. 1993;76(6):1505‐1510. PubMed

Sidoroff M, Kolho KL. Screening for adrenal suppression in children with inflammatory bowel disease discontinuing glucocorticoid therapy. BMC Gastroenterol. 2014;14:51. PubMed PMC

Khan KJ, Dubinsky MC, Ford AC, Ullman TA, Talley NJ, Moayyedi P. Efficacy of immunosuppressive therapy for inflammatory bowel disease: a systematic review and meta‐analysis. Am J Gastroenterol. 2011;106(4):630‐642. PubMed

Gisbert JP, Linares PM, McNicholl AG, Maté J, Gomollón F. Meta‐analysis: the efficacy of azathioprine and mercaptopurine in ulcerative colitis. Aliment Pharmacol Ther. 2009;30(2):126‐137. PubMed

Timmer A, Patton PH, Chande N, McDonald JW, MacDonald JK. Azathioprine and 6‐mercaptopurine for maintenance of remission in ulcerative colitis. Cochrane Database Syst Rev. 2016;2016(5):CD000478. PubMed PMC

Barabino A, Torrente F, Ventura A, Cucchiara S, Castro M, Barbera C. Azathioprine in paediatric inflammatory bowel disease: an Italian multicentre survey. Aliment Pharmacol Ther. 2002;16(6):1125‐1130. PubMed

Kader HA, Mascarenhas MR, Piccoli DA, Stouffer NO, Baldassano RN. Experiences with 6‐mercaptopurine and azathioprine therapy in pediatric patients with severe ulcerative colitis. J Pediatr Gastroenterol Nutr. 1999;28(1):54‐58. PubMed

Verhave M, Winter HS, Grand RJ. Azathioprine in the treatment of children with inflammatory bowel disease. J Pediatr. 1990;117(5):809‐814. PubMed

Tajiri H, Tomomasa T, Yoden A, et al. Efficacy and safety of azathioprine and 6‐mercaptopurine in Japanese pediatric patients with ulcerative colitis: a survey of the Japanese Society for Pediatric Inflammatory Bowel Disease. Digestion. 2008;77(3‐4):150‐154. PubMed

Aloi M, D'Arcangelo G, Bramuzzo M, et al. Effect of early versus late azathioprine therapy in pediatric ulcerative colitis. Inflamm Bowel Dis. 2016;22(7):1647‐1654. PubMed

Hyams JS, Lerer T, Mack D, et al. Outcome following thiopurine use in children with ulcerative colitis: a prospective multicenter registry study. Am J Gastroenterol. 2011;106(5):981‐987. PubMed

Pozler O, Chládek J, Malý J, et al. Steady‐state of azathioprine during initiation treatment of pediatric inflammatory bowel disease. J Crohns Colitis. 2010;4(6):623‐628. PubMed

Atia O, Ledder O, Ben‐Moshe T, et al. Role of thiopurines in pediatric inflammatory bowel diseases: a real‐life prospective cohort study. J Pediatr Gastroenterol Nutr. 2020;70(6):825‐832. PubMed

Abu Hanna F, Atia O, Yerushalmy Feler A, et al. Thiopurines maintenance therapy in children with ulcerative colitis: a multicenter retrospective study. J Pediatr Gastroenterol Nutr. 2023;77(4):505‐511. PubMed

Chhaya V, Pollok RCG, Cecil E, et al. Impact of early thiopurines on surgery in 2770 children and young people diagnosed with inflammatory bowel disease: a national population‐based study. Aliment Pharmacol Ther. 2015;42(8):990‐999. PubMed

Mantzaris GJ, Sfakianakis M, Archavlis E, et al. A prospective randomized observer‐blind 2‐year trial of azathioprine monotherapy versus azathioprine and olsalazine for the maintenance of remission of steroid‐dependent ulcerative colitis. Am J Gastroenterol. 2004;99(6):1122‐1128. PubMed

Szumlanski C, Weinshilboum R. Sulphasalazine inhibition of thiopurine methyltransferase: possible mechanism for interaction with 6‐mercaptopurine and azathioprine. Br J Clin Pharmacol. 1995;39(4):456‐459. PubMed PMC

Andrews JM, Travis SPL, Gibson PR, Gasche C. Systematic review: does concurrent therapy with 5‐ASA and immunomodulators in inflammatory bowel disease improve outcomes? Aliment Pharmacol Ther. 2009;29(5):459‐469. PubMed

Grossman AB, Noble AJ, Mamula P, Baldassano RN. Increased dosing requirements for 6‐mercaptopurine and azathioprine in inflammatory bowel disease patients six years and younger. Inflamm Bowel Dis. 2008;14(6):750‐755. PubMed

Stocco G, Martelossi S, Arrigo S, et al. Multicentric case‐control study on azathioprine dose and pharmacokinetics in early‐onset pediatric inflammatory bowel disease. Inflamm Bowel Dis. 2017;23(4):628‐634. PubMed

Pratt VM, Cavallari LH, Fulmer ML, et al. TPMT and NUDT15 genotyping recommendations: a joint consensus recommendation of the Association for Molecular Pathology, Clinical Pharmacogenetics Implementation Consortium, College of American Pathologists, Dutch Pharmacogenetics Working Group of the Royal Dutch Pharmacists Association, European Society for Pharmacogenomics and Personalized Therapy, and Pharmacogenomics Knowledgebase. J Mol Diagn. 2022;24(10):1051‐1063. PubMed PMC

Desai D, Jena A, Sharma V, Hibi T. Time to incorporate preemptive NUDT15 testing before starting thiopurines in inflammatory bowel disease in Asia and beyond: a review. Expert Rev Clin Pharmacol. 2023;16(7):643‐653. PubMed

Coenen MJH, de Jong DJ, van Marrewijk CJ, et al. Identification of patients with variants in TPMT and dose reduction reduces hematologic events during thiopurine treatment of inflammatory bowel disease. Gastroenterology. 2015;149(4):907‐917.e7. PubMed

Gazouli M, Pachoula I, Panayotou I, et al. Thiopurine methyltransferase genotype and thiopurine S‐methyltransferase activity in Greek children with inflammatory bowel disease. Ann Gastroenterol. 2012;25(3):249‐253. PubMed PMC

De Ridder L, Van Dieren JM, Van Deventer HJH, et al. Pharmacogenetics of thiopurine therapy in paediatric IBD patients. Aliment Pharmacol Ther. 2006;23(8):1137‐1141. PubMed

Gerich ME, Quiros JA, Marcin JP, Tennyson L, Henthorn M, Prindiville TP. A prospective evaluation of the impact of allopurinol in pediatric and adult IBD patients with preferential metabolism of 6‐mercaptopurine to 6‐methylmercaptopurine. J Crohns Colitis. 2010;4(5):546‐552. PubMed

Rahhal RM, Bishop WP. Initial clinical experience with allopurinol‐thiopurine combination therapy in pediatric inflammatory bowel disease. Inflamm Bowel Dis. 2008;14(12):1678‐1682. PubMed

Pavlidis P, Stamoulos P, Abdulrehman A, et al. Long‐term safety and efficacy of low‐dose azathioprine and allopurinol cotherapy in inflammatory bowel disease: a large observational study. Inflamm Bowel Dis. 2016;22(7):1639‐1646. PubMed

Ihekweazu FD, Kellermayer R. Allopurinol: a useful adjunct to thiopurine therapy for pediatric ulcerative colitis in the biologic era. J Pediatr Gastroenterol Nutr. 2014;59(1):22‐24. PubMed

Konidari A, Anagnostopoulos A, Bonnett LJ, Pirmohamed M, El‐Matary W. Thiopurine monitoring in children with inflammatory bowel disease: a systematic review. Br J Clin Pharmacol. 2014;78(3):467‐476. PubMed PMC

Banerjee S, Bishop WP. Evolution of thiopurine use in pediatric inflammatory bowel disease in an academic center. J Pediatr Gastroenterol Nutr. 2006;43(3):324‐330. PubMed

Walker R. Azathioprine dosing and metabolite measurement in pediatric inflammatory bowel disease: does one size fit all? Ann Gastroenterol. 2019;32(4):387‐391. PubMed PMC

Lennard L, Singleton HJ. High‐performance liquid chromatographic assay of the methyl and nucleotide metabolites of 6‐mercaptopurine: quantitation of red blood cell 6‐thioguanine nucleotide, 6‐thioinosinic acid and 6‐methylmercaptopurine metabolites in a single sample. J Chromatogr B: Biomed Sci Appl. 1992;583(1):83‐90. PubMed

Hanai H, Iida T, Takeuchi K, et al. Thiopurine maintenance therapy for ulcerative colitis: the clinical significance of monitoring 6‐thioguanine nucleotide. Inflamm Bowel Dis. 2010;16(8):1376‐1381. PubMed

Wong DR, Coenen MJH, Vermeulen SH, et al. Early assessment of thiopurine metabolites identifies patients at risk of thiopurine‐induced leukopenia in inflammatory bowel disease. J Crohns Colitis. 2017;11(2):175‐184. PubMed

Nguyen TVA, Vu DH, Nguyen TMH, Lachaux A, Boulieu R. Exploring associations of 6‐thioguanine nucleotide levels and other predictive factors with therapeutic response to azathioprine in pediatric patients with IBD using multilevel analysis. Inflamm Bowel Dis. 2013;19(11):2404‐2410. PubMed

Lee MN, Kang B, Choi SY, et al. Relationship between azathioprine dosage, 6‐thioguanine nucleotide levels, and therapeutic response in pediatric patients with IBD treated with azathioprine. Inflamm Bowel Dis. 2015;21(5):1054‐1062. PubMed

Ooi CY, Bohane TD, Lee D, Naidoo D, Day AS. Thiopurine metabolite monitoring in paediatric inflammatory bowel disease. Aliment Pharmacol Ther. 2007;25(8):941‐947. PubMed

Bąk‐Drabik K, Adamczyk P, Duda‐Wrońska J, Dąbrowska‐Piechota D, Jarzumbek A, Kwiecień J. Usefulness of measuring thiopurine metabolites in children with inflammatory bowel disease and autoimmunological hepatitis, treated with azathioprine. Gastroenterol Res Pract. 2021;2021:1‐10. PubMed PMC

Nguyen TVA, Nguyen TMH, Lachaux A, Boulieu R. Usefulness of thiopurine metabolites in predicting azathioprine resistance in pediatric IBD patients. J Clin Pharmacol. 2013;53(9):900‐908. PubMed

Fuentes D, Torrente F, Keady S, et al. High‐dose azathioprine in children with inflammatory bowel disease. Aliment Pharmacol Ther. 2003;17(7):913‐921. PubMed

Salzmann M, von Graffenried T, Righini‐Grunder F, et al. Drug‐related adverse events necessitating treatment discontinuation in pediatric inflammatory bowel disease patients. J Pediatr Gastroenterol Nutr. 2022;75(6):731‐736. PubMed PMC

Jagt JZ, Pothof CD, Buiter HJC, et al. Adverse events of thiopurine therapy in pediatric inflammatory bowel disease and correlations with metabolites: a cohort study. Dig Dis Sci. 2022;67(1):241‐251. PubMed PMC

Kirschner BS. Safety of azathioprine and 6‐mercaptopurine in pediatric patients with inflammatory bowel disease. Gastroenterology. 1998;115(4):813‐821. PubMed

Sandborn WJ. A review of immune modifier therapy for inflammatory bowel disease: azathioprine, 6‐mercaptopurine, cyclosporine, and methotrexate. Am J Gastroenterol. 1996;91(3):423‐433. PubMed

Connell WR, Kamm MA, Ritchie JK, Lennard‐Jones JE. Bone marrow toxicity caused by azathioprine in inflammatory bowel disease: 27 years of experience. Gut. 1993;34(8):1081‐1085. PubMed PMC

Kennedy NA, Rhatigan E, Arnott IDR, et al. A trial of mercaptopurine is a safe strategy in patients with inflammatory bowel disease intolerant to azathioprine: an observational study, systematic review and meta‐analysis. Aliment Pharmacol Ther. 2013;38(10):1255‐1266. PubMed

Shih DQ, Nguyen M, Zheng L, et al. Split‐dose administration of thiopurine drugs: a novel and effective strategy for managing preferential 6‐MMP metabolism. Aliment Pharmacol Ther. 2012;36(5):449‐458. PubMed

Cococcioni L, Pensabene L, Puoti MG, et al. Safety and efficacy of split‐dose thiopurine vs low‐dose thiopurine‐allopurinol cotherapy in pediatric inflammatory bowel disease. Clin Transl Gastroenterol. 2023;14(3):e00544. PubMed PMC

Dubinsky MC, Vasiliauskas EA, Singh H, et al. 6‐thioguanine can cause serious liver injury in inflammatory bowel disease patients. Gastroenterology. 2003;125(2):298‐303. PubMed

Bayoumy AB, Jagt JZ, van Wering HM, et al. Safety of thioguanine in pediatric inflammatory bowel disease: a multi‐center case series. J Pediatr Gastroenterol Nutr. 2022;75(6):e111‐e115. PubMed PMC

Kotlyar DS, Lewis JD, Beaugerie L, et al. Risk of lymphoma in patients with inflammatory bowel disease treated with azathioprine and 6‐mercaptopurine: a meta‐analysis. Clin Gastroenterol Hepatol. 2015;13(5):847‐858.e4. PubMed

Chupin A, Perduca V, Meyer A, Bellanger C, Carbonnel F, Dong C. Systematic review with meta‐analysis: comparative risk of lymphoma with anti‐tumour necrosis factor agents and/or thiopurines in patients with inflammatory bowel disease. Aliment Pharmacol Ther. 2020;52(8):1289‐1297. PubMed

Atia O, Harel S, Ledderman N, et al. Risk of cancer in paediatric onset inflammatory bowel diseases: a nation‐wide study from the epi‐IIRN. J Crohns Colitis. 2022;16(5):786‐795. PubMed

Shah ED, Coburn ES, Nayyar A, Lee KJ, Koliani‐Pace JL, Siegel CA. Systematic review: hepatosplenic T‐cell lymphoma on biologic therapy for inflammatory bowel disease, including data from the Food and Drug Administration Adverse Event Reporting System. Aliment Pharmacol Ther. 2020;51(5):527‐533. PubMed PMC

Dohos D, Hanák L, Szakács Z, et al. Systematic review with meta‐analysis: the effects of immunomodulator or biological withdrawal from mono‐ or combination therapy in inflammatory bowel disease. Aliment Pharmacol Ther. 2021;53(2):220‐233. PubMed PMC

Cassinotti A, Actis GC, Duca P, et al. Maintenance treatment with azathioprine in ulcerative colitis: outcome and predictive factors after drug withdrawal. Am J Gastroenterol. 2009;104(11):2760‐2767. PubMed

Moreno‐Rincón E, Benítez JM, Serrano‐Ruiz FJ, et al. Prognosis of patients with ulcerative colitis in sustained remission after thiopurines withdrawal. Inflamm Bowel Dis. 2015;21(7):1564‐1571. PubMed

Kennedy NA, Kalla R, Warner B, et al. Thiopurine withdrawal during sustained clinical remission in inflammatory bowel disease: relapse and recapture rates, with predictive factors in 237 patients. Aliment Pharmacol Ther. 2014;40(11‐12):1313‐1323. PubMed PMC

Li Y, Li CF, Zhang J, et al. Features of patients with inflammatory bowel diseases who develop hemophagocytic lymphohistiocytosis. Int J Colorectal Dis. 2016;31(7):1375‐1376. PubMed

Biank VF, Sheth MK, Talano J, et al. Association of Crohn's disease, thiopurines, and primary Epstein‐Barr virus infection with hemophagocytic lymphohistiocytosis. J Pediatr. 2011;159(5):808‐812. PubMed PMC

Kucharzik T, Ellul P, Greuter T, et al. ECCO guidelines on the prevention, diagnosis, and management of infections in inflammatory bowel disease. J Crohns Colitis. 2021;15(6):879‐913. PubMed

Gordon J, Ramaswami A, Beuttler M, et al. EBV status and thiopurine use in pediatric IBD. J Pediatr Gastroenterol Nutr. 2016;62(5):711‐714. PubMed

Bachmann J, Le Thi G, Brückner A, et al. Epstein‐Barr virus prevalence at diagnosis and seroconversion during follow‐up in pediatric inflammatory bowel disease. J Clin Med. 2021;10(21):5187. PubMed PMC

Harris RE, Hegde V, Curtis L, et al. Epstein‐Barr virus status and subsequent thiopurine exposure within a paediatric inflammatory bowel disease population. J Pediatr Gastroenterol Nutr. 2021;73(3):358‐362. PubMed

Lam GY. Lymphoproliferative disorders in inflammatory bowel disease patients on immunosuppression: lessons from other inflammatory disorders. World J Gastrointest Pathophysiol. 2015;6(4):181‐192. PubMed PMC

Gordon M, Sinopoulou V, Akobeng AK, Pana M, Gasiea R, Moran GW. Tacrolimus (FK506) for induction of remission in corticosteroid‐refractory ulcerative colitis. Cochrane Database Syst Rev. 2022;4(4):007216. PubMed PMC

Bolia R, Goel A, Semwal P, Srivastava A. Oral tacrolimus in steroid refractory and dependent pediatric ulcerative colitis—a systematic review and meta‐analysis. J Pediatr Gastroenterol Nutr. 2023;77(2):228‐234. PubMed

Ogata H. A randomised dose finding study of oral tacrolimus (FK506) therapy in refractory ulcerative colitis. Gut. 2006;55(9):1255‐1262. PubMed PMC

Nielsen OH, Steenholdt C, Juhl CB, Rogler G. Efficacy and safety of methotrexate in the management of inflammatory bowel disease: a systematic review and meta‐analysis of randomized, controlled trials. EClinicalMedicine. 2020;20:100271. PubMed PMC

Carbonnel F, Colombel JF, Filippi J, et al. Methotrexate is not superior to placebo for inducing steroid‐free remission, but induces steroid‐free clinical remission in a larger proportion of patients with ulcerative colitis. Gastroenterology. 2016;150(2):380‐388.e4. PubMed

Herfarth H, Barnes EL, Valentine JF, et al. Methotrexate is not superior to placebo in maintaining steroid‐free response or remission in ulcerative colitis. Gastroenterology. 2018;155(4):1098‐1108.e9. PubMed PMC

Han M, Jung YS, Cheon JH, Park S. Similar clinical outcomes of early and late anti‐TNF initiation for ulcerative colitis: a nationwide population‐based study. Yonsei Med J. 2020;61(5):382‐390. PubMed PMC

Targownik LE, Bernstein CN, Benchimol EI, et al. Earlier anti‐TNF initiation leads to long‐term lower health care utilization in Crohn's disease but not in ulcerative colitis. Clin Gastroenterol Hepatol. 2022;20(11):2607‐2618.e14. PubMed

Ben‐Horin S, Novack L, Mao R, et al. Efficacy of biologic drugs in short‐duration versus long‐duration inflammatory bowel disease: a systematic review and an individual‐patient data meta‐analysis of randomized controlled trials. Gastroenterology. 2022;162(2):482‐494. PubMed

Lujan R, Focht G, Atia O, et al. Does early initiation of biologics change the natural history of IBD in Pediatrics? A nationwide study from epi‐IIRN. ESPGHAN Annual Meeting; May 17–20, 2023; Vienna.

Atia O, Orlanski‐Meyer E, Lujan R, et al. Colectomy rates did not decrease in paediatric‐ and adult‐onset ulcerative colitis during the biologics era: a nationwide study from the epi‐IIRN. J Crohns Colitis. 2022;16(5):796‐803. PubMed

Atia O, Friss C, Focht G, et al. Durability of the first biologic in children and adults with ulcerative colitis: a nationwide study from the epi‐IIRN. Inflamm Bowel Dis. 2025;31(3):617‐624. PubMed

Hyams J, Damaraju L, Blank M, et al. Induction and maintenance therapy with infliximab for children with moderate to severe ulcerative colitis. Clin Gastroenterol Hepatol. 2012;10(4):391‐399.e1. PubMed

Kelsen JR, Grossman AB, Pauly‐Hubbard H, Gupta K, Baldassano RN, Mamula P. Infliximab therapy in pediatric patients 7 years of age and younger. J Pediatr Gastroenterol Nutr. 2014;59(6):758‐762. PubMed

Adedokun OJ, Xu Z, Padgett L, et al. Pharmacokinetics of infliximab in children with moderate‐to‐severe ulcerative colitis: results from a randomized, multicenter, open‐label, phase 3 study. Inflamm Bowel Dis. 2013;19(13):2753‐2762. PubMed

Church PC, Ho S, Sharma A, et al. Intensified infliximab induction is associated with improved response and decreased colectomy in steroid‐refractory paediatric ulcerative colitis. J Crohns Colitis. 2019;13(8):982‐989. PubMed

Atia O, Pujol‐Muncunill G, Navas‐López VM, et al. Children included in randomised controlled trials of biologics in inflammatory bowel diseases do not represent the real‐world patient mix. Aliment Pharmacol Ther. 2022;56(5):794‐801. PubMed PMC

Turner D, Griffiths AM. Acute severe ulcerative colitis in children: a systematic review. Inflamm Bowel Dis. 2011;17(1):440‐449. PubMed

Hyams JS, Lerer T, Griffiths A, et al. Outcome following infliximab therapy in children with ulcerative colitis. Am J Gastroenterol. 2010;105(6):1430‐1436. PubMed

Larsen MD, Qvist N, Nielsen J, Kjeldsen J, Nielsen RG, Nørgård BM. Use of anti‐TNFα agents and time to first‐time surgery in paediatric patients with ulcerative colitis and Crohn's disease. J Crohns Colitis. 2016;10(6):650‐656. PubMed

Schreiber S, Ben‐Horin S, Leszczyszyn J, et al. Randomized controlled trial: subcutaneous vs intravenous infliximab CT‐P13 maintenance in inflammatory bowel disease. Gastroenterology. 2021;160(7):2340‐2353. PubMed

Husman J, Černá K, Matthes K, et al. Subcutaneous infliximab in Crohn's disease patients with previous immunogenic failure of intravenous infliximab. Int J Colorectal Dis. 2024;39(1):151. PubMed PMC

Gianolio L, Armstrong K, Swann E, et al. Effectiveness of switching to subcutaneous infliximab in pediatric inflammatory bowel disease patients on intravenous maintenance therapy. J Pediatr Gastroenterol Nutr. 2023;77(2):235‐239. PubMed

Croft NM, Jr. Faubion, WA , Kugathasan S, et al. Efficacy and safety of adalimumab in paediatric patients with moderate‐to‐severe ulcerative colitis (ENVISION I): a randomised, controlled, phase 3 study. Lancet Gastroenterol Hepatol. 2021;6(8):616‐627. PubMed

Ruemmele FM, Veres G, Kolho KL, et al. Consensus guidelines of ECCO/ESPGHAN on the medical management of pediatric Crohn's disease. J Crohns Colitis. 2014;8(10):1179‐1207. PubMed

Aloi M, Bramuzzo M, Arrigo S, et al. Efficacy and safety of adalimumab in pediatric ulcerative colitis: a real‐life experience from the SIGENP‐IBD registry. J Pediatr Gastroenterol Nutr. 2018;66(6):920‐925. PubMed

de Ridder L, Assa A, Bronsky J, et al. Use of biosimilars in pediatric inflammatory bowel disease: an updated position statement of the pediatric IBD Porto Group of ESPGHAN. J Pediatr Gastroenterol Nutr. 2019;68(1):144‐153. PubMed

Vickers AD, Ainsworth C, Mody R, et al. Systematic review with network meta‐analysis: comparative efficacy of biologics in the treatment of moderately to severely active ulcerative colitis. PLoS One. 2016;11(10):e0165435. PubMed PMC

Cholapranee A, Hazlewood GS, Kaplan GG, Peyrin‐Biroulet L, Ananthakrishnan AN. Systematic review with meta‐analysis: comparative efficacy of biologics for induction and maintenance of mucosal healing in Crohn's disease and ulcerative colitis controlled trials. Aliment Pharmacol Ther. 2017;45(10):1291‐1302. PubMed PMC

Burr NE, Gracie DJ, Black CJ, et al. Efficacy of biological therapies and small molecules in moderate to severe ulcerative colitis: systematic review and network meta‐analysis. Gut. 2022;71(10):1976‐1987. PubMed

Singh S, Murad MH, Fumery M, Dulai PS, Sandborn WJ. First‐ and second‐line pharmacotherapies for patients with moderate to severely active ulcerative colitis: an updated network meta‐analysis. Clin Gastroenterol Hepatol. 2020;18(10):2179‐2191.e6. PubMed PMC

Mao EJ, Hazlewood GS, Kaplan GG, Peyrin‐Biroulet L, Ananthakrishnan AN. Systematic review with meta‐analysis: comparative efficacy of immunosuppressants and biologics for reducing hospitalisation and surgery in Crohn's disease and ulcerative colitis. Aliment Pharmacol Ther. 2017;45(1):3‐13. PubMed

Jung YS, Han M, Park S, Cheon JH. Biologic use patterns and predictors for non‐persistence and switching of biologics in patients with inflammatory bowel disease: a nationwide population‐based study. Dig Dis Sci. 2020;65(5):1436‐1444. PubMed

Singh S, Andersen NN, Andersson M, Loftus EV, Jess T. Comparison of infliximab and adalimumab in biologic‐naive patients with ulcerative colitis: a nationwide Danish cohort study. Clin Gastroenterol Hepatol. 2017;15(8):1218‐1225.e7. PubMed PMC

Lee YI, Park Y, Park SJ, Kim TI, Kim WH, Cheon JH. Comparison of long‐term outcomes of infliximab versus adalimumab treatment in biologic‐naïve patients with ulcerative colitis. Gut Liver. 2021;15(2):232‐242. PubMed PMC

Volonaki E, Mutalib M, Kiparissi F, Shah N, Lindley KJ, Elawad M. Adalimumab as a second‐line biological therapy in children with refractory ulcerative colitis. Eur J Gastroenterol Hepatol. 2015;27(12):1425‐1428. PubMed

Vahabnezhad E, Rabizadeh S, Dubinsky MC. A 10‐year, single tertiary care center experience on the durability of infliximab in pediatric inflammatory bowel disease. Inflamm Bowel Dis. 2014;20(4):606‐613. PubMed PMC

Narula N, Wong ECL, Marshall JK, Colombel JF, Dulai PS, Reinisch W. Comparative efficacy for infliximab vs vedolizumab in biologic naive ulcerative colitis. Clin Gastroenterol Hepatol. 2022;20(7):1588‐1597.e3. PubMed

Panaccione R, Ghosh S, Middleton S, et al. Combination therapy with infliximab and azathioprine is superior to monotherapy with either agent in ulcerative colitis. Gastroenterology. 2014;146(2):392‐400 e3. PubMed

Wong ECL, Merat S, Monaco C, et al. Comparative efficacy of infliximab versus tofacitinib for inducing remission in biologic naive ulcerative colitis: a propensity matched study. Dig Dis Sci. 2023;68(6):2635‐2646. PubMed

Nanau RM, Cohen LE, Neuman MG. Risk of infections of biological therapies with accent on inflammatory bowel disease. J Pharm Pharm Sci. 2014;17(4):485‐531. PubMed

Lemaitre M, Kirchgesner J, Rudnichi A, et al. Association between use of thiopurines or tumor necrosis factor antagonists alone or in combination and risk of lymphoma in patients with inflammatory bowel disease. JAMA. 2017;318(17):1679‐1686. PubMed PMC

Jacobstein DA, Markowitz JE, Kirschner BS, et al. Premedication and infusion reactions with infliximab: results from a pediatric inflammatory bowel disease consortium. Inflamm Bowel Dis. 2005;11(5):442‐446. PubMed

Farrell RJ, Alsahli M, Jeen YT, Falchuk KR, Peppercorn MA, Michetti P. Intravenous hydrocortisone premedication reduces antibodies to infliximab in Crohn's disease: a randomized controlled trial. Gastroenterology. 2003;124(4):917‐924. PubMed

Lahdenne P, Wikström AM, Aalto K, Kolho KL. Prevention of acute adverse events related to infliximab infusions in pediatric patients. Arthritis Care Res. 2010;62(6):785‐790. PubMed

Lichtenstein GR, Feagan BG, Cohen RD, et al. Serious infection and mortality in patients with Crohn's disease: more than 5 years of follow‐up in the TREAT registry. Am J Gastroenterol. 2012;107(9):1409‐1422. PubMed PMC

Andersen NN, Jess T. Risk of infections associated with biological treatment in inflammatory bowel disease. World J Gastroenterol. 2014;20(43):16014‐16019. PubMed PMC

Hyams JS, Dubinsky MC, Baldassano RN, et al. Infliximab is not associated with increased risk of malignancy or hemophagocytic lymphohistiocytosis in pediatric patients with inflammatory bowel disease. Gastroenterology. 2017;152(8):1901‐1914.e3. PubMed

Jongsma MME, Winter DA, Huynh HQ, et al. Infliximab in young paediatric IBD patients: it is all about the dosing. Eur J Pediatr. 2020;179(12):1935‐1944. PubMed PMC

Bauman LE, Xiong Y, Mizuno T, et al. Improved population pharmacokinetic model for predicting optimized infliximab exposure in pediatric inflammatory bowel disease. Inflamm Bowel Dis. 2020;26(3):429‐439. PubMed PMC

Singh S, Dulai PS, Zarrinpar A, Ramamoorthy S, Sandborn WJ. Obesity in IBD: epidemiology, pathogenesis, disease course and treatment outcomes. Nat Rev Gastroenterol Hepatol. 2017;14(2):110‐121. PubMed PMC

Kurnool S, Nguyen NH, Proudfoot J, et al. High body mass index is associated with increased risk of treatment failure and surgery in biologic‐treated patients with ulcerative colitis. Aliment Pharmacol Ther. 2018;47(11):1472‐1479. PubMed PMC

Papamichael K, Cheifetz AS, Melmed GY, et al. Appropriate therapeutic drug monitoring of biologic agents for patients with inflammatory bowel diseases. Clin Gastroenterol Hepatol. 2019;17(9):1655‐1668.e3. PubMed PMC

Ward MG, Thwaites PA, Beswick L, et al. Intra‐patient variability in adalimumab drug levels within and between cycles in Crohn's disease. Aliment Pharmacol Ther. 2017;45(8):1135‐1145. PubMed

Kato M, Sugimoto K, Ikeya K, et al. Therapeutic monitoring of adalimumab at non‐trough levels in patients with inflammatory bowel disease. PLoS One. 2021;16(7):e0254548. PubMed PMC

Feagan BG, Rutgeerts P, Sands BE, et al. Vedolizumab as induction and maintenance therapy for ulcerative colitis. N Engl J Med. 2013;369(8):699‐710. PubMed

Loftus, Jr. EV , Colombel JF, Feagan BG, et al. Long‐term efficacy of vedolizumab for ulcerative colitis. J Crohns Colitis. 2017;11(4):400‐411. PubMed

Singh N, Rabizadeh S, Jossen J, et al. Multi‐center experience of vedolizumab effectiveness in pediatric inflammatory bowel disease. Inflamm Bowel Dis. 2016;22(9):2121‐2126. PubMed

Ledder O, Assa A, Levine A, et al. Vedolizumab in paediatric inflammatory bowel disease: a retrospective multi‐centre experience from the paediatric IBD Porto group of ESPGHAN. J Crohns Colitis. 2017;11(10):1230‐1237. PubMed

Attauabi M, Madsen GR, Bendtsen F, Seidelin JB, Burisch J. P530 vedolizumab as the first line of biologic therapy for ulcerative colitis and Crohn's disease – a systematic review with meta‐analysis. J Crohns Colitis. 2022;16:i483‐i484. PubMed

Atia O, Shavit‐Brunschwig Z, Mould DR, et al. Outcomes, dosing, and predictors of vedolizumab treatment in children with inflammatory bowel disease (VEDOKIDS): a prospective, multicentre cohort study. Lancet Gastroenterol Hepatol. 2023;8(1):31‐42. PubMed

Atia O, Shavit‐Brunschwig Z, Lev‐Tzion R, et al. Maintenance treatment with vedolizumab in paediatric inflammatory bowel disease (VEDOKIDS): 54‐week outcomes of a multicentre, prospective, cohort study. Lancet Gastroenterol Hepatol. 2025;10(3):234‐247. PubMed

Hajjat TM, Mosha M, Whaley KG, et al. Vedolizumab experience in children and adolescents with inflammatory bowel disease: a multicenter observational study. Crohns Colitis 360. 2021;3(3):otab039. PubMed PMC

Garcia‐Romero R, Martinez de Zabarte Fernandez JM, Pujol‐Muncunill G, et al. Safety and effectiveness of vedolizumab in paediatric patients with inflammatory bowel disease: an observational multicentre Spanish study. Eur J Pediatr. 2021;180(9):3029‐3038. PubMed

Sands BE, Peyrin‐Biroulet L, Loftus, Jr. EV , et al. Vedolizumab versus adalimumab for moderate‐to‐severe ulcerative colitis. N Engl J Med. 2019;381(13):1215‐1226. PubMed

Sands BE, Sandborn WJ, Panaccione R, et al. Ustekinumab as induction and maintenance therapy for ulcerative colitis. N Engl J Med. 2019;381(13):1201‐1214. PubMed

Danese S, Sands BE, Abreu MT, et al. Early symptomatic improvement after ustekinumab therapy in patients with ulcerative colitis: 16‐week data from the UNIFI trial. Clin Gastroenterol Hepatol. 2022;20(12):2858‐2867.e5. PubMed

Cohen S, Rolandsdotter H, Kolho KL, et al. Effectiveness and safety of ustekinumab in pediatric ulcerative colitis: a multi‐center retrospective study from the pediatric IBD Porto group of ESPGHAN. Paediatr Drugs. 2024;26(5):609‐617. PubMed PMC

Dhaliwal J, McKay HE, Deslandres C, et al. One‐year outcomes with ustekinumab therapy in infliximab‐refractory paediatric ulcerative colitis: a multicentre prospective study. Aliment Pharmacol Ther. 2021;53(12):1300‐1308. PubMed

Koudsi M, Martinez‐Vinson C, Pigneur B, et al. Ustekinumab use in pediatric inflammatory bowel disease: a French multicenter study from the pediatric GETAID. J Pediatr Gastroenterol Nutr. 2023;76(6):763‐770. PubMed

Rosh JR, Turner D, Griffiths A, et al. Ustekinumab in paediatric patients with moderately to severely active Crohn's disease: pharmacokinetics, safety, and efficacy results from UniStar, a phase 1 study. J Crohns Colitis. 2021;15(11):1931‐1942. PubMed PMC

Hanžel J, D'Haens GR. Anti‐interleukin‐23 agents for the treatment of ulcerative colitis. Expert Opin Biol Ther. 2020;20(4):399‐406. PubMed

D'Haens G, Dubinsky M, Kobayashi T, et al. Mirikizumab as induction and maintenance therapy for ulcerative colitis. N Engl J Med. 2023;388(26):2444‐2455. PubMed

Louis E, Schreiber S, Panaccione R, et al. Risankizumab for ulcerative colitis: two randomized clinical trials. JAMA. 2024;332(11):881‐897. PubMed PMC

Hyams JS, Chan D, Adedokun OJ, et al. Subcutaneous golimumab in pediatric ulcerative colitis: pharmacokinetics and clinical benefit. Inflamm Bowel Dis. 2017;23(12):2227‐2237. PubMed

Adedokun OJ, Xu Z, Marano CW, et al. Pharmacokinetics and exposure‐response relationship of golimumab in patients with moderately‐to‐severely active ulcerative colitis: results from phase 2/3 PURSUIT induction and maintenance studies. J Crohns Colitis. 2017;11(1):35‐46. PubMed PMC

Sandborn WJ, Feagan BG, Marano C, et al. Subcutaneous golimumab maintains clinical response in patients with moderate‐to‐severe ulcerative colitis. Gastroenterology. 2014;146(1):96‐109 e1. PubMed

Hyams JS, O'Brien CD, Padgett L, et al. Maintenance golimumab treatment in pediatric UC patients with moderately to severely active UC: PURSUIT PEDS PK long‐term study results. Crohns Colitis 360. 2020;2(4):063. PubMed PMC

Sandborn WJ, Su C. Tofacitinib as induction and maintenance therapy for ulcerative colitis. N Engl J Med. 2017;377(5):496‐497. PubMed

Colombel JF, Osterman MT, Thorpe AJ, et al. Maintenance of remission with tofacitinib therapy in patients with ulcerative colitis. Clin Gastroenterol Hepatol. 2022;20(1):116‐125.e5. PubMed

Dhindsa B, Dhaliwal A, Mashiana H, et al. 827 Efficacy and safety of tofacitinib in moderate‐severe ulcerative colitis: a systematic review and meta‐analysis. Am J Gastroenterol. 2019;114:S478.

Lucaciu LA, Constantine‐Cooke N, Plevris N, et al. Real‐world experience with tofacitinib in ulcerative colitis: a systematic review and meta‐analysis. Therap Adv Gastroenterol. 2021;14:17562848211064004. PubMed PMC

Ledder O, Dolinger M, Dubinsky MC, et al. Tofacitinib in pediatric ulcerative colitis: a retrospective multicenter experience. Inflamm Bowel Dis. 2025;31(2):425‐431. PubMed

Ryan N, Cooper S, Dominik A, et al. Outcomes of tofacitinib use in an Irish pediatric cohort. JPGN Rep. 2023;4(3):e332. PubMed PMC

Moore H, Dubes L, Fusillo S, Baldassano R, Stein R. Tofacitinib therapy in children and young adults with pediatric‐onset medically refractory inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2021;73(3):e57‐e62. PubMed

Buisson A, Nachury M, Guilmoteau T, et al. Real‐world comparison of effectiveness between tofacitinib and vedolizumab in patients with ulcerative colitis exposed to at least one anti‐TNF agent. Aliment Pharmacol Ther. 2023;57(6):676‐688. PubMed

Danese S, Vermeire S, Zhou W, et al. Upadacitinib as induction and maintenance therapy for moderately to severely active ulcerative colitis: results from three phase 3, multicentre, double‐blind, randomised trials. Lancet. 2022;399(10341):2113‐2128. PubMed

Panes J, Loftus EV, Higgins PDR, et al. Induction and maintenance treatment with upadacitinib improves health‐related quality of life in patients with moderately to severely active ulcerative colitis: phase 3 study results. Inflamm Bowel Dis. 2023;29(9):1421‐1430. PubMed PMC

Vermeire S, Danese S, Zhou W, et al. Efficacy and safety of upadacitinib maintenance therapy for moderately to severely active ulcerative colitis in patients responding to 8 week induction therapy (U‐ACHIEVE maintenance): overall results from the randomised, placebo‐controlled, double‐blind, phase 3 maintenance study. Lancet Gastroenterol Hepatol. 2023;8(11):976‐989. PubMed

Yerushalmy‐Feler A, Spencer EA, Dolinger MT, et al. Upadacitinib for induction of remission in pediatric ulcerative colitis: an international multi‑center study. J Crohns Colitis. 2025;19(5):jjae182. PubMed

Sandborn WJ, Feagan BG, D'Haens G, et al. Ozanimod as induction and maintenance therapy for ulcerative colitis. N Engl J Med. 2021;385(14):1280‐1291. PubMed

Sandborn WJ, Vermeire S, Peyrin‐Biroulet L, et al. Etrasimod as induction and maintenance therapy for ulcerative colitis (ELEVATE): two randomised, double‐blind, placebo‐controlled, phase 3 studies. Lancet. 2023;401(10383):1159‐1171. PubMed

Yerushalmy‐Feler A, Brauner C, Cohen S. Dual‐targeted therapy in pediatric inflammatory bowel disease: a comprehensive review. Pediatr Drugs. 2023;25(5):489‐498. PubMed

Kellar A, Dolinger MT, Spencer EA, Dubinsky MC. Real‐world outcomes of dual advanced therapy in children and young adults with inflammatory bowel disease. Dig Dis Sci. 2024;69(5):1826‐1833. PubMed

Feagan BG, Sands BE, Sandborn WJ, et al. Guselkumab plus golimumab combination therapy versus guselkumab or golimumab monotherapy in patients with ulcerative colitis (VEGA): a randomised, double‐blind, controlled, phase 2, proof‐of‐concept trial. Lancet Gastroenterol Hepatol. 2023;8(4):307‐320. PubMed

Yerushalmy‐Feler A, Olbjorn C, Kolho KL, et al. Dual biologic or small molecule therapy in refractory pediatric inflammatory bowel disease (DOUBLE‐PIBD): a multicenter study from the pediatric IBD Porto group of ESPGHAN. Inflamm Bowel Dis. 2024;30(2):159‐166. PubMed

Arenas A, Moreta MJ, Ordás I, et al. De‐escalating therapy in inflammatory bowel disease: results from an observational study in clinical practice. Gastroenterol Hepatol. 2024;47(7):673‐682. PubMed

Scarallo L, Bolasco G, Barp J, et al. Anti‐tumor necrosis factor‐alpha withdrawal in children with inflammatory bowel disease in endoscopic and histologic remission. Inflamm Bowel Dis. 2022;28(2):183‐191. PubMed

Gisbert JP, Chaparro M. De‐escalation of biological treatment in inflammatory bowel disease: a comprehensive review. J Crohns Colitis. 2024;18(4):642‐658. PubMed

Mahmoud R, Savelkoul EHJ, Mares W, et al. Complete endoscopic healing is associated with lower relapse risk after anti‐TNF withdrawal in inflammatory bowel disease. Clin Gastroenterol Hepatol. 2023;21(3):750‐760.e4. PubMed

Breton J, Kastl A, Hoffmann N, et al. Efficacy of combination antibiotic therapy for refractory pediatric inflammatory bowel disease. Inflamm Bowel Dis. 2019;25(9):1586‐1593. PubMed PMC

Coelho MR, Romi MD, Ferreira DMTP, Zaltman C, Soares‐Mota M. The use of curcumin as a complementary therapy in ulcerative colitis: a systematic review of randomized controlled clinical trials. Nutrients. 2020;12(8):2296. PubMed PMC

Crothers JW, Chu ND, Nguyen LTT, et al. Daily, oral FMT for long‐term maintenance therapy in ulcerative colitis: results of a single‐center, prospective, randomized pilot study. BMC Gastroenterol. 2021;21(1):281. PubMed PMC

El Hage Chehade N, Ghoneim S, Shah S, et al. Efficacy of fecal microbiota transplantation in the treatment of active ulcerative colitis: a systematic review and meta‐analysis of double‐blind randomized controlled trials. Inflamm Bowel Dis. 2023;29(5):808‐817. PubMed

Akutko K, Stawarski A. Probiotics, prebiotics and synbiotics in inflammatory bowel diseases. J Clin Med. 2021;10(11):2466. PubMed PMC

Atreya R, Bloom S, Scaldaferri F, et al. Clinical effects of a topically applied toll‐like receptor 9 agonist in active moderate‐to‐severe ulcerative colitis. J Crohns Colitis. 2016;10(11):1294‐1302. PubMed PMC

Brezina J, Bajer L, Wohl P, et al. Fecal microbial transplantation versus mesalamine enema for treatment of active left‐sided ulcerative colitis—results of a randomized controlled trial. J Clin Med. 2021;10(13):2753. PubMed PMC

Fritsch J, Garces L, Quintero MA, et al. Low‐fat, high‐fiber diet reduces markers of inflammation and dysbiosis and improves quality of life in patients with ulcerative colitis. Clin Gastroenterol Hepatol. 2021;19(6):1189‐1199.e30. PubMed

Chande N, Costello SP, Limketkai BN, et al. Alternative and complementary approaches for the treatment of inflammatory bowel disease: evidence from Cochrane reviews. Inflamm Bowel Dis. 2020;26(6):843‐851. PubMed

Cold F, Baunwall SMD, Dahlerup JF, Petersen AM, Hvas CL, Hansen LH. Systematic review with meta‐analysis: encapsulated faecal microbiota transplantation – evidence for clinical efficacy. Therap Adv Gastroenterol. 2021;14:17562848211041004. PubMed PMC

Allegretti JR, Kelly CR, Grinspan A, et al. Inflammatory bowel disease outcomes following fecal microbiota transplantation for recurrent PubMed PMC

Faecal Microbiota Transplantation. EU‐IN Horizon Scanning Report. https://www.ema.europa.eu/en/documents/report/faecal-microbiota-transplantation-eu-horizon-scanning-report_en.pdf

Cheng F, Huang Z, Li Z, et al. Efficacy and safety of fecal microbiota transplant for recurrent PubMed

Levast B, Fontaine M, Nancey S, Dechelotte P, Doré J, Lehert P. Single‐donor and pooling strategies for fecal microbiota transfer product preparation in ulcerative colitis: a systematic review and meta‐analysis. Clin Transl Gastroenterol. 2023;14(5):e00568. PubMed PMC

Moayyedi P, Surette MG, Kim PT, et al. Fecal microbiota transplantation induces remission in patients with active ulcerative colitis in a randomized controlled trial. Gastroenterology. 2015;149(1):102‐109.e6. PubMed

Okahara K, Ishikawa D, Nomura K, et al. Matching between donors and ulcerative colitis patients is important for long‐term maintenance after fecal microbiota transplantation. J Clin Med. 2020;9(6):1650. PubMed PMC

Zhang B, Yang L, Ning H, et al. A matching strategy to guide donor selection for ulcerative colitis in fecal microbiota transplantation: meta‐analysis and analytic hierarchy process. Microbiol Spectr. 2023;11(1):e0215921. PubMed PMC

Fuentes S, Rossen NG, van der Spek MJ, et al. Microbial shifts and signatures of long‐term remission in ulcerative colitis after faecal microbiota transplantation. ISME J. 2017;11(8):1877‐1889. PubMed PMC

Goyal A, Yeh A, Bush BR, et al. Safety, clinical response, and microbiome findings following fecal microbiota transplant in children with inflammatory bowel disease. Inflamm Bowel Dis. 2018;24(2):410‐421. PubMed

Pai N, Popov J, Hill L, et al. Results of the first pilot randomized controlled trial of fecal microbiota transplant in pediatric ulcerative colitis: lessons, limitations, and future prospects. Gastroenterology. 2021;161(2):388‐393.e3. PubMed

Hsu M, Tun KM, Batra K, Haque L, Vongsavath T, Hong AS. Safety and efficacy of fecal microbiota transplantation in treatment of inflammatory bowel disease in the pediatric population: a systematic review and meta‐analysis. Microorganisms. 2023;11(5):1272. PubMed PMC

Kedia S, Virmani S, Vuyyuru SK, et al. Faecal microbiota transplantation with anti‐inflammatory diet (FMT‐AID) followed by anti‐inflammatory diet alone is effective in inducing and maintaining remission over 1 year in mild to moderate ulcerative colitis: a randomised controlled trial. Gut. 2022;71(12):2401‐2413. PubMed

Sarbagili‐Shabat C, Albenberg L, Van Limbergen J, et al. A novel UC exclusion diet and antibiotics for treatment of mild to moderate pediatric ulcerative colitis: a prospective open‐label pilot study. Nutrients. 2021;13(11):3736. PubMed PMC

González‐Huix F, Fernández‐Bañares F, Esteve‐Comas M, et al. Enteral versus parenteral nutrition as adjunct therapy in acute ulcerative colitis. Am J Gastroenterol. 1993;88(2):227‐232. PubMed

Cox SR, Lindsay JO, Fromentin S, et al. Effects of low FODMAP diet on symptoms, fecal microbiome, and markers of inflammation in patients with quiescent inflammatory bowel disease in a randomized trial. Gastroenterology. 2020;158(1):176‐188.e7. PubMed

Strisciuglio C, Cenni S, Serra MR, et al. Effectiveness of Mediterranean diet's adherence in children with inflammatory bowel diseases. Nutrients. 2020;12(10):3206. PubMed PMC

Haskey N, Estaki M, Ye J, et al. A Mediterranean diet pattern improves intestinal inflammation concomitant with reshaping of the bacteriome in ulcerative colitis: a randomized controlled trial. J Crohns Colitis. 2023. PubMed PMC

Sarbagili Shabat C, Scaldaferri F, Zittan E, et al. Use of faecal transplantation with a novel diet for mild to moderate active ulcerative colitis: the CRAFT UC randomised controlled trial. J Crohns Colitis. 2022;16(3):369‐378. PubMed PMC

Levine A, Rhodes JM, Lindsay JO, et al. Dietary guidance from the International Organization for the Study of Inflammatory Bowel Diseases. Clin Gastroenterol Hepatol. 2020;18(6):1381‐1392. PubMed

Gordon M, Sinopoulou V, Grafton‐Clarke C, et al. Antibiotics for the induction and maintenance of remission in ulcerative colitis. Cochrane Database Syst Rev. 2022;5:CD013743. PubMed PMC

Kaur L, Gordon M, Baines PA, Iheozor‐Ejiofor Z, Sinopoulou V, Akobeng AK. Probiotics for induction of remission in ulcerative colitis. Cochrane Database Syst Rev. 2020;3(3):005573. PubMed PMC

Iheozor‐Ejiofor Z, Kaur L, Gordon M, Baines PA, Sinopoulou V, Akobeng AK. Probiotics for maintenance of remission in ulcerative colitis. Cochrane Database Syst Rev. 2020;3(3):007443. PubMed PMC

Armstrong HK, Bording‐Jorgensen M, Santer DM, et al. Unfermented β‐fructan fibers fuel inflammation in select inflammatory bowel disease patients. Gastroenterology. 2023;164(2):228‐240. PubMed

Szajewska H, Berni Canani R, Domellöf M, et al. Probiotics for the management of pediatric gastrointestinal disorders: position paper of the ESPGHAN special interest group on gut microbiota and modifications. J Pediatr Gastroenterol Nutr. 2023;76(2):232‐247. PubMed

Guo X, Liu C, Huang Y. Efficacy and safety of vitamin D adjuvant therapy for ulcerative colitis: a meta‐analysis. Comput Math Methods Med. 2022;2022:6836942. PubMed PMC

Chandan S, Mohan BP, Chandan OC, et al. Curcumin use in ulcerative colitis: is it ready for prime time? A systematic review and meta‐analysis of clinical trials. Ann Gastroenterol. 2020;33(1):53‐58. PubMed PMC

Banerjee RPP, Pal P, Penmetsa A, et al. Novel bioenhanced curcumin with mesalamine for induction of clinical and endoscopic remission in mild‐to‐moderate ulcerative colitis: a randomized double‐blind placebo‐controlled pilot study. J Clin Gastroenterol. 2021;55(8):702‐708. PubMed

Lang A, Salomon N, Wu JCY, et al. Curcumin in combination with mesalamine induces remission in patients with mild‐to‐moderate ulcerative colitis in a randomized controlled trial. Clin Gastroenterol Hepatol. 2015;13(8):1444‐1449.e1. PubMed

Hanai HL, Iida T, Takeuchi K, et al. Curcumin maintenance therapy for ulcerative colitis: randomized, multicentre, double‐blind, placebo‐controlled trial. Clin Gastroenterol Hepatol. 2006;4(12):347‐356. PubMed

Ben‐Horin S, Salomon N, Karampekos G, et al. Curcumin‐QingDai combination for patients with active ulcerative colitis: a randomized, double‐blinded, placebo‐controlled trial. Clin Gastroenterol Hepatol. 2024;22(2):347‐356.e6. PubMed

Nachum NL, Salomon N, Yerushalmy‐Feler A, et al. The efficacy of curcumin/Qing Dai combination in children with active ulcerative colitis: a multicenter retrospective cohort study. Front Pediatr. 2024;12:1342656. PubMed PMC

Naganuma M, Sugimoto S, Mitsuyama K, et al. Efficacy of indigo naturalis in a multicenter randomized controlled trial of patients with ulcerative colitis. Gastroenterology. 2018;154(4):935‐947. PubMed

Yanai H, Salomon N, Lahat A, et al. Real‐world experience with curcumin–QingDai combination for patients with active ulcerative colitis: a retrospective multicentre cohort study. Aliment Pharmacol Ther. 2023;58(2):175‐181. PubMed

Kakdiya R, Jha DK, Choudhury A, Jena A, Sharma V. Indigo naturalis (Qing dai) for inflammatory bowel disease: a systematic review and meta‐analysis. Clin Res Hepatol Gastroenterol. 2024;48:102250. PubMed

Ruuska T, Küster P, Grahnquist L, Lindgren F, Wewer AV. Efficacy and safety of granulocyte, monocyte/macrophage adsorptive in pediatric ulcerative colitis. World J Gastroenterol. 2016;22(17):4389‐4396. PubMed PMC

Rolandsdotter H, Eberhardson M, Fagerberg UL, Finkel Y. Granulocyte and monocyte apheresis for induction of remission in children with new‐onset inflammatory bowel colitis. J Pediatr Gastroenterol Nutr. 2018;66(1):84‐89. PubMed

Sands BE, Sandborn WJ, Feagan B, et al. A randomized, double‐blind, sham‐controlled study of granulocyte/monocyte apheresis for active ulcerative colitis. Gastroenterology. 2008;135:400‐409. PubMed

Tanaka T, Yamamoto T, Sawada K, Sacco R. Treatment options for children and adolescents with inflammatory bowel disease: is granulomonocytapheresis an effective alternative to drug therapy? Expert Rev Gastroenterol Hepatol. 2017;11(8):749‐758. PubMed

Everhov ÅH, Sachs MC, Malmborg P, et al. Changes in inflammatory bowel disease subtype during follow‐up and over time in 44,302 patients. Scand J Gastroenterol. 2019;54(1):55‐63. PubMed

Bequet E, Sarter H, Fumery M, et al. Incidence and phenotype at diagnosis of very‐early‐onset compared with later‐onset paediatric inflammatory bowel disease: a population‐based study [1988‐2011]. J Crohns Colitis. 2017;11(5):519‐526. PubMed

Winter DA, Karolewska‐Bochenek K, Lazowska‐Przeorek I, et al. Pediatric IBD‐unclassified is less common than previously reported; results of an 8‐year audit of the EUROKIDS registry. Inflamm Bowel Dis. 2015;21(9):2145‐2153. PubMed

Burisch J, Zammit SC, Ellul P, et al. Disease course of inflammatory bowel disease unclassified in a European population‐based inception cohort: an Epi‐IBD study. J Gastroenterol Hepatol. 2019;34(6):996‐1003. PubMed

Chandradevan R, Hofmekler T, Mondal K, et al. Evolution of pediatric inflammatory bowel disease unclassified (IBD‐U): incorporated with serological and gene expression profiles. Inflamm Bowel Dis. 2018;24(10):2285‐2290. PubMed

Duarte H, Stolfi A, McCall C, Saeed S, Sandberg K. Diagnosis change in pediatric inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2024;78(3):623‐633. PubMed

Wands DIF, Gianolio L, Cameron F, et al. Pediatric inflammatory bowel disease type unclassified: a nationwide cohort study in Scotland with up to 20 years follow‐up shows reclassification in the majority and mild course in those whose diagnosis is unchanged. Inflamm Bowel Dis. 2025;31(2):313‐320. PubMed

Dhaliwal J, Siddiqui I, Muir J, et al. Differentiation of colonic inflammatory bowel disease: re‐examination of paediatric inflammatory bowel disease classes algorithm with resected colon as the criterion standard. J Pediatr Gastroenterol Nutr. 2020;70(2):218‐224. PubMed

Aloi M, Birimberg‐Schwartz L, Buderus S, et al. Treatment options and outcomes of pediatric IBDU compared with other IBD subtypes: a retrospective multicenter study from the IBD Porto group of ESPGHAN. Inflamm Bowel Dis. 2016;22(6):1378‐1383. PubMed

Koh SZ, Zaghiyan KN, Li Q, et al. Clinical factors associated with the development of Crohn's disease in inflammatory bowel disease‐unclassified patients undergoing ileal pouch‐anal anastomosis. Inflamm Bowel Dis. 2016;22(6):1397‐1402. PubMed

Zaghiyan K, Kaminski JP, Barmparas G, Fleshner P. De novo Crohn's disease after ileal pouch‐anal anastomosis for ulcerative colitis and inflammatory bowel disease unclassified: long‐term follow‐up of a prospective inflammatory bowel disease registry. Am Surg. 2016;82(10):977‐981. PubMed

Aljomah G, Baker SS, Schmidt K, et al. Anemia in pediatric inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2018;67(3):351‐355. PubMed

Wiskin AE, Fleming BJ, Wootton SA, Beattie RM. Anaemia and iron deficiency in children with inflammatory bowel disease. J Crohns Colitis. 2012;6(6):687‐691. PubMed

Carvalho FSG, de Medeiros IA, Antunes H. Prevalence of iron deficiency anemia and iron deficiency in a pediatric population with inflammatory bowel disease. Scand J Gastroenterol. 2017;52(10):1099‐1103. PubMed

Sjöberg D, Holmström T, Larsson M, Nielsen AL, Holmquist L, Rönnblom A. Anemia in a population‐based IBD cohort (ICURE): still high prevalence after 1 year, especially among pediatric patients. Inflamm Bowel Dis. 2014;20(12):2266‐2270. PubMed

Pels LP, Van de Vijver E, Waalkens HJ, et al. Slow hematological recovery in children with IBD‐associated anemia in cases of “expectant management”. J Pediatr Gastroenterol Nutr. 2010;51(6):708‐713. PubMed

Rempel J, Grover K, El‐Matary W. Micronutrient deficiencies and anemia in children with inflammatory bowel disease. Nutrients. 2021;13(1):236. PubMed PMC

Gerasimidis K, Barclay A, Papangelou A, et al. The epidemiology of anemia in pediatric inflammatory bowel disease: prevalence and associated factors at diagnosis and follow‐up and the impact of exclusive enteral nutrition. Inflamm Bowel Dis. 2013;19(11):2411‐2422. PubMed

Rampton DS, Goodhand JR, Joshi NM, et al. Oral iron treatment response and predictors in anaemic adolescents and adults with IBD: a prospective controlled open‐label trial. J Crohns Colitis. 2017;11(6):706‐715. PubMed PMC

Shentova‐Eneva R, Kofinova D, Hadzhiyski P, Yaneva P, Lazarova E, Baycheva M. Anemia in newly diagnosed pediatric patients with inflammatory bowel disease. Gastroenterol Insights. 2021;12(4):376‐383.

Martinelli M, Strisciuglio C, Alessandrella A, et al. Serum hepcidin and iron absorption in paediatric inflammatory bowel disease. J Crohns Colitis. 2016;10(5):566‐574. PubMed PMC

Wells CW, Lewis S, Barton RJ, Corbett S. Effects of changes in hemoglobin level on quality of life and cognitive function in inflammatory bowel disease patients. Inflamm Bowel Dis. 2006;12(2):123‐130. PubMed

Danko I, Weidkamp M, Eickhoff JC. Improvement of health‐related quality of life in children with inflammatory bowel disease receiving routine intravenous iron supplementation. J Pediatr Pharmacol Ther. 2019;24(6):517‐527. PubMed PMC

Evstatiev R, Marteau P, Iqbal T, et al. FERGIcor, a randomized controlled trial on ferric carboxymaltose for iron deficiency anemia in inflammatory bowel disease. Gastroenterology. 2011;141(3):846‐853.e2. PubMed

Gisbert JP, Gomollón F. Common misconceptions in the diagnosis and management of anemia in inflammatory bowel disease. Am J Gastroenterol. 2008;103(5):1299‐1307. PubMed

Jacobson‐Kelly AE, Stanek JR, Powers JM, Dotson JL, O'Brien SH. Trends in anemia, iron, therapy, and transfusion in hospitalized pediatric patients with inflammatory bowel disease. J Pediatr. 2020;222:141‐145.e1. PubMed

World Health Organization . Iron deficiency anemia: assessment, prevention and control. A guide for programme managers. A report of United Nations Children's Fund, United Nations University and World Health Organization. https://www.who.int/publications/m/item/iron-children-6to23--archived-iron-deficiency-anaemia-assessment-prevention-and-control

World Health Organization . Haemoglobin Concentrations for the Diagnosis of Anaemia and Assessment of Severity. World Health Organization; 2011.

Maas LA, Krishna M, Parian AM. Ironing it all out: a comprehensive review of iron deficiency anemia in inflammatory bowel disease patients. Dig Dis Sci. 2023;68(2):357‐369. PubMed

Nielsen OH, Ainsworth M, Coskun M, Weiss G. Management of iron‐deficiency anemia in inflammatory bowel disease: a systematic review. Medicine. 2015;94(23):e963. PubMed PMC

Mücke V. Diagnosis and treatment of anemia in patients with inflammatory bowel disease. Ann Gastroenterol. 2016;30(1):15‐22. PubMed PMC

Murawska N, Fabisiak A, Fichna J. Anemia of chronic disease and iron deficiency anemia in inflammatory bowel diseases. Inflamm Bowel Dis. 2016;22(5):1198‐1208. PubMed

Karaskova E, Pospisilova D, Velganova‐Veghova M, et al. Importance of hepcidin in the etiopathogenesis of anemia in inflammatory bowel disease. Dig Dis Sci. 2021;66(10):3263‐3269. PubMed

Karaskova E, Volejnikova J, Holub D, et al. Hepcidin in newly diagnosed inflammatory bowel disease in children. J Paediatr Child Health. 2018;54(12):1362‐1367. PubMed

Lee TW, Kolber MR, Fedorak RN, van Zanten SV. Iron replacement therapy in inflammatory bowel disease patients with iron deficiency anemia: a systematic review and meta‐analysis. J Crohns Colitis. 2012;6(3):267‐275. PubMed

Avni T, Bieber A, Steinmetz T, Leibovici L, Gafter‐Gvili A. Treatment of anemia in inflammatory bowel disease—systematic review and meta‐analysis. PLoS One. 2013;8(12):e75540. PubMed PMC

Bonovas S, Fiorino G, Allocca M, et al. Intravenous versus oral iron for the treatment of anemia in inflammatory bowel disease: a systematic review and meta‐analysis of randomized controlled trials. Medicine. 2016;95(2):e2308. PubMed PMC

Gordon M, Sinopoulou V, Iheozor‐Ejiofor Z, et al. Interventions for treating iron deficiency anaemia in inflammatory bowel disease. Cochrane Database Syst Rev. 2021;1(1):CD013529. PubMed PMC

Bevers N, Van De Vijver E, Aliu A, et al. Ferric carboxymaltose versus ferrous fumarate in anemic children with inflammatory bowel disease: the POPEYE randomized controlled clinical trial. J Pediatr. 2023;256:113‐119.e4. PubMed

D'Arcangelo G, Distante M, Veraldi S, Tarani F, Musto F, Aloi M. Natural history of anemia and efficacy and safety of oral iron therapy in children newly diagnosed with inflammatory bowel disease. J Pediatri Gastroenterol Nutr. 2023;76(6):771‐775. PubMed

Tolkien Z, Stecher L, Mander AP, Pereira DIA, Powell JJ. Ferrous sulfate supplementation causes significant gastrointestinal side‐effects in adults: a systematic review and meta‐analysis. PLoS One. 2015;10(2):e0117383. PubMed PMC

Lugg S, Beal F, Nightingale P, Bhala N, Iqbal T. Iron treatment and inflammatory bowel disease: what happens in real practice? J Crohns Colitis. 2014;8(8):876‐880. PubMed

Lee T, Clavel T, Smirnov K, et al. Oral versus intravenous iron replacement therapy distinctly alters the gut microbiota and metabolome in patients with IBD. Gut. 2017;66(5):863‐871. PubMed PMC

Farrell D, Artom M, Czuber‐Dochan W, Jelsness‐Jørgensen LP, Norton C, Savage E. Interventions for fatigue in inflammatory bowel disease. Cochrane Database Syst Rev. 2020;2020(4):CD012005. PubMed PMC

Gasche C, Ahmad T, Tulassay Z, et al. Ferric maltol is effective in correcting iron deficiency anemia in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2015;21(3):579‐588. PubMed PMC

Howaldt S, Domènech E, Martinez N, Schmidt C, Bokemeyer B. Long‐term effectiveness of oral ferric maltol vs intravenous ferric carboxymaltose for the treatment of iron‐deficiency anemia in patients with inflammatory bowel disease: a randomized controlled noninferiority trial. Inflamm Bowel Dis. 2022;28(3):373‐384. PubMed PMC

Abbati G, Incerti F, Boarini C, et al. Safety and efficacy of sucrosomial iron in inflammatory bowel disease patients with iron deficiency anemia. Intern Emerg Med. 2019;14(3):423‐431. PubMed

Stoffel NU, Cercamondi CI, Brittenham G, et al. Iron absorption from oral iron supplements given on consecutive versus alternate days and as single morning doses versus twice‐daily split dosing in iron‐depleted women: two open‐label, randomised controlled trials. Lancet Haematol. 2017;4(11):e524‐e533. PubMed

Stoffel NU, von Siebenthal HK, Moretti D, Zimmermann MB. Oral iron supplementation in iron‐deficient women: how much and how often? Mol Aspects Med. 2020;75:100865. PubMed

Moretti D, Goede JS, Zeder C, et al. Oral iron supplements increase hepcidin and decrease iron absorption from daily or twice‐daily doses in iron‐depleted young women. Blood. 2015;126(17):1981‐1989. PubMed

Stoffel NU, Zeder C, Brittenham GM, Moretti D, Zimmermann MB. Iron absorption from supplements is greater with alternate day than with consecutive day dosing in iron‐deficient anemic women. Haematologica. 2020;105(5):1232‐1239. PubMed PMC

Kamath S, Parveen RS, Hegde S, Mathias EG, Nayak V, Boloor A. Daily versus alternate day oral iron therapy in iron deficiency anemia: a systematic review. Naunyn Schmiedebergs Arch Pharmacol. 2024;397(5):2701‐2714. PubMed

Andersen CT, Marsden DM, Duggan CP, Liu E, Mozaffarian D, Fawzi WW. Oral iron supplementation and anaemia in children according to schedule, duration, dose and cosupplementation: a systematic review and meta‐analysis of 129 randomised trials. BMJ Glob Health. 2023;8(2):e010745. PubMed PMC

Blumenstein I, Shanbhag S, Langguth P, Kalra PA, Zoller H, Lim W. Newer formulations of intravenous iron: a review of their chemistry and key safety aspects – hypersensitivity, hypophosphatemia, and cardiovascular safety. Expert Opin Drug Saf. 2021;20(7):757‐769. PubMed

Avni T, Bieber A, Grossman A, Green H, Leibovici L, Gafter‐Gvili A. The safety of intravenous iron preparations. Mayo Clin Proc. 2015;90(1):12‐23. PubMed

Akhuemonkhan E, Parian A, Carson KA, Hutfless S. Adverse reactions after intravenous iron infusion among inflammatory bowel disease patients in the United States, 2010–2014. Inflamm Bowel Dis. 2018;24(8):1801‐1807. PubMed PMC

Papadopoulos M, Patel D, Korologou‐Linden R, et al. Safety and efficacy of parenteral iron in children with inflammatory bowel disease. Br J Clin Pharmacol. 2018;84(4):694‐699. PubMed PMC

Sabe R, Vatsayan A, Mahran A, Khalili AS, Ahuja S, Sferra TJ. Safety and efficacy of intravenous iron sucrose for iron‐deficiency anemia in children and adolescents with inflammatory bowel disease. Glob Pediatr Health. 2019;6:2333794X1987098. PubMed PMC

Laass MW, Straub S, Chainey S, Virgin G, Cushway T. Effectiveness and safety of ferric carboxymaltose treatment in children and adolescents with inflammatory bowel disease and other gastrointestinal diseases. BMC Gastroenterol. 2014;14(1):184. PubMed PMC

Sasankan N, Duncan H, Curtis L, et al. Ferric carboxymaltose across all ages in paediatric gastroenterology shows efficacy without increased safety concerns. J Pediatr Gastroenterol Nutr. 2021;72(4):506‐510. PubMed

Carman N, Muir R, Lewindon P. Ferric carboxymaltose in the treatment of iron deficiency in pediatric inflammatory bowel disease. Transl Pediatr. 2019;8(1):28‐34. PubMed PMC

Stein RE, Plantz K, Maxwell EC, Mamula P, Baldassano RN. Intravenous iron sucrose for treatment of iron deficiency anemia in pediatric inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2018;66(2):e51‐e55. PubMed

Venturieri MO, Komati JTS, Lopes LHC, Sdepanian VL. Treatment with noripurum EV® is effective and safe in pediatric patients with inflammatory bowel disease and iron deficiency anemia. Scand J Gastroenterol. 2019;54(2):198‐204. PubMed

Cococcioni L, Pensabene L, El‐Khouly S, et al. Ferric carboxymaltose treatment for iron deficiency anemia in children with inflammatory bowel disease: efficacy and risk of hypophosphatemia. Dig Liver Dis. 2021;53(7):830‐834. PubMed

Danko I, Weidkamp M. Correction of iron deficiency anemia with intravenous iron sucrose in children with inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2016;63(5):e107‐e111. PubMed

Kaenkumchorn TK, Mark D, Niedner K, et al. Association between iron deficit repletion with ferric carboxymaltose relative to iron sucrose in children with inflammatory bowel disease: a retrospective cohort study. J Parenter Enter Nutr. 2023;47(5):670‐676. PubMed

Aksan A, Işık H, Radeke HH, Dignass A, Stein J. Systematic review with network meta‐analysis: comparative efficacy and tolerability of different intravenous iron formulations for the treatment of iron deficiency anaemia in patients with inflammatory bowel disease. Aliment Pharmacol Ther. 2017;45(10):1303‐1318. PubMed

Kennedy NA, Achebe MM, Biggar P, Pöhlmann J, Pollock RF. A systematic literature review and meta‐analysis of the incidence of serious or severe hypersensitivity reactions after administration of ferric derisomaltose or ferric carboxymaltose. Int J Clin Pharm. 2023;45(3):604‐612. PubMed PMC

Rampton D, Folkersen J, Fishbane S, et al. Hypersensitivity reactions to intravenous iron: guidance for risk minimization and management. Haematologica. 2014;99(11):1671‐1676. PubMed PMC

Zoller H, Schaefer B, Glodny B. Iron‐induced hypophosphatemia: an emerging complication. Curr Opin Nephrol Hypertens. 2017;26(4):266‐275. PubMed

Wolf M, Koch TA, Bregman DB. Effects of iron deficiency anemia and its treatment on fibroblast growth factor 23 and phosphate homeostasis in women. J Bone Miner Res. 2013;28(8):1793‐1803. PubMed

Wolf M, Chertow GM, Macdougall IC, Kaper R, Krop J, Strauss W. Randomized trial of intravenous iron‐induced hypophosphatemia. JCI Insight. 2018;3(23):e124486. PubMed PMC

Detlie TE, Lindstrøm JC, Jahnsen ME, et al. Hypophosphatemia after high‐dose intravenous iron treatment in patients with inflammatory bowel disease: mechanisms and possible clinical impact. World J Gastroenterol. 2021;27(17):2039‐2053. PubMed PMC

Kirk SE, Scheurer ME, Bernhardt MB, Mahoney DH, Powers JM. Phosphorus levels in children treated with intravenous ferric carboxymaltose. Am J Hematol. 2021;96(6):E215‐E218. PubMed PMC

Klein K, Asaad S, Econs M, Rubin JE. Severe FGF23‐based hypophosphataemic osteomalacia due to ferric carboxymaltose administration. BMJ Case Rep. 2018;2018:bcr2017222851. PubMed PMC

Vilaca T, Velmurugan N, Smith C, Abrahamsen B, Eastell R. Osteomalacia as a complication of intravenous iron infusion: a systematic review of case reports. J Bone Miner Res. 2020;37(6):1188‐1199. PubMed PMC

Glaspy JA, Lim‐Watson MZ, Libre MA, et al. Hypophosphatemia associated with intravenous iron therapies for iron deficiency anemia: a systematic literature review. Ther Clin Risk Manag. 2020;16:245‐259. PubMed PMC

Schaefer B, Tobiasch M, Viveiros A, et al. Hypophosphataemia after treatment of iron deficiency with intravenous ferric carboxymaltose or iron isomaltoside—a systematic review and meta‐analysis. Br J Clin Pharmacol. 2021;87(5):2256‐2273. PubMed PMC

Harris RE, Armstrong L, Curtis L, et al. Severe hypophosphataemia following ferric carboxymaltose infusion in paediatric patients with inflammatory bowel disease. Frontline Gastroenterol. 2020;11(4):324‐326. PubMed PMC

Imel EA, Econs MJ. Approach to the hypophosphatemic patient. J Clin Endocrinol Metab. 2012;97(3):696‐706. PubMed PMC

Schaefer B, Tobiasch M, Wagner S, et al. Hypophosphatemia after intravenous iron therapy: comprehensive review of clinical findings and recommendations for management. Bone. 2022;154:116202. PubMed

Patel D, Trivedi C, Khan N. Management of anemia in patients with inflammatory bowel disease (IBD). Curr Treat Options Gastroenterol. 2018;16(1):112‐128. PubMed

Martin J, Radeke HH, Dignass A, et al. Current evaluation and management of anemia in patients with inflammatory bowel disease. Expert Rev Gastroenterol Hepatol. 2021;11(1):19‐32. PubMed

Litton E, Xiao J, Ho KM. Safety and efficacy of intravenous iron therapy in reducing requirement for allogeneic blood transfusion: systematic review and meta‐analysis of randomised clinical trials. BMJ. 2013;347(1):f4822. PubMed PMC

García‐Erce JA, Gomollón F, Muñoz M. Blood transfusion for the treatment of acute anaemia in inflammatory bowel disease and other digestive diseases. World J Gastroenterol. 2009;15(37):4686‐4694. PubMed PMC

Klein HG, Spahn DR, Carson JL. Red blood cell transfusion in clinical practice. Lancet. 2007;370(9585):415‐426. PubMed

Gordon H, Burisch J, Ellul P, et al. ECCO guidelines on extraintestinal manifestations in inflammatory bowel disease. J Crohns Colitis. 2024;18(1):1‐37. PubMed

Rogler G, Singh A, Kavanaugh A, Rubin DT. Extraintestinal manifestations of inflammatory bowel disease: current concepts, treatment, and implications for disease management. Gastroenterology. 2021;161(4):1118‐1132. PubMed PMC

Dotson JL, Hyams JS, Markowitz J, et al. Extraintestinal manifestations of pediatric inflammatory bowel disease and their relation to disease type and severity. J Pediatr Gastroenterol Nutr. 2010;51(2):140‐145. PubMed

Jose FA, Garnett EA, Vittinghoff E, et al. Development of extraintestinal manifestations in pediatric patients with inflammatory bowel disease. Inflamm Bowel Dis. 2009;15(1):63‐68. PubMed PMC

Aloi M, Cucchiara S. Extradigestive manifestations of IBD in pediatrics. Eur Rev Med Pharmacol Sci. 2009;13(suppl 1):23‐32. PubMed

Hyams JS. Extraintestinal manifestations of inflammatory bowel disease in children. J Pediatr Gastroenterol Nutr. 1994;19(1):7‐21. PubMed

Greuter T, Bertoldo F, Rechner R, et al. Extraintestinal manifestations of pediatric inflammatory bowel disease: prevalence, presentation, and anti‐TNF treatment. J Pediatr Gastroenterol Nutr. 2017;65(2):200‐206. PubMed

Moninuola OO, Milligan W, Lochhead P, Khalili H. Systematic review with meta‐analysis: association between acetaminophen and nonsteroidal anti‐inflammatory drugs (NSAIDs) and risk of Crohn's disease and ulcerative colitis exacerbation. Aliment Pharmacol Ther. 2018;47(11):1428‐1439. PubMed PMC

O'Toole A, Lucci M, Korzenik J. Inflammatory bowel disease provoked by etanercept: report of 443 possible cases combined from an IBD referral center and the FDA. Dig Dis Sci. 2016;61(6):1772‐1774. PubMed

Gossec L, Kerschbaumer A, Ferreira RJO, et al. EULAR recommendations for the management of psoriatic arthritis with pharmacological therapies: 2023 update. Ann Rheum Dis. 2024;83(6):706‐719. PubMed PMC

Ricciuto A, Kamath BM, Hirschfield GM, Trivedi PJ. Primary sclerosing cholangitis and overlap features of autoimmune hepatitis: a coming of age or an age‐ist problem? J Hepatol. 2023;79(2):567‐575. PubMed

Barberio B, Massimi D, Cazzagon N, Zingone F, Ford AC, Savarino EV. Prevalence of primary sclerosing cholangitis in patients with inflammatory bowel disease: a systematic review and meta‐analysis. Gastroenterology. 2021;161(6):1865‐1877. PubMed

Culver EL, Bungay HK, Betts M, et al. Prevalence and long‐term outcome of sub‐clinical primary sclerosing cholangitis in patients with ulcerative colitis. Liver Int. 2020;40(11):2744‐2757. PubMed

de Groof EJ, Rossen NGM, van Rhijn BD, et al. Burden of disease and increasing prevalence of inflammatory bowel disease in a population‐based cohort in the Netherlands. Eur J Gastroenterol Hepatol. 2016;28(9):1065‐1072. PubMed

Trivedi PJ, Crothers H, Mytton J, et al. Effects of primary sclerosing cholangitis on risks of cancer and death in people with inflammatory bowel disease, based on sex, race, and age. Gastroenterology. 2020;159(3):915‐928. PubMed

Weismüller TJ, Trivedi PJ, Bergquist A, et al. Patient age, sex, and inflammatory bowel disease phenotype associate with course of primary sclerosing cholangitis. Gastroenterology. 2017;152(8):1975‐1984.e8. PubMed PMC

Lunder AK, Hov JR, Borthne A, et al. Prevalence of sclerosing cholangitis detected by magnetic resonance cholangiography in patients with long‐term inflammatory bowel disease. Gastroenterology. 2016;151(4):660‐669.e4. PubMed

Ponsioen CY. Diagnosis, differential diagnosis, and epidemiology of primary sclerosing cholangitis. Dig Dis. 2015;33(suppl 2):134‐139. PubMed

Jorgensen KK, Grzyb K, Lundin KE, et al. Inflammatory bowel disease in patients with primary sclerosing cholangitis: clinical characterization in liver transplanted and nontransplanted patients. Inflamm Bowel Dis. 2012;18(3):536‐545. PubMed

Boonstra K, van Erpecum KJ, van Nieuwkerk KMJ, et al. Primary sclerosing cholangitis is associated with a distinct phenotype of inflammatory bowel disease. Inflamm Bowel Dis. 2012;18(12):2270‐2276. PubMed

Joo M, Abreu‐e‐Lima P, Farraye F, et al. Pathologic features of ulcerative colitis in patients with primary sclerosing cholangitis: a case‐control study. Am J Surg Pathol. 2009;33(6):854‐862. PubMed

Sano H, Nakazawa T, Ando T, et al. Clinical characteristics of inflammatory bowel disease associated with primary sclerosing cholangitis. J Hepatobiliary Pancreat Sci. 2011;18(2):154‐161. PubMed

Haskell H, Andrews, Jr. CW , Reddy SI, et al. Pathologic features and clinical significance of “backwash” ileitis in ulcerative colitis. Am J Surg Pathol. 2005;29(11):1472‐1481. PubMed

Broome U. Primary sclerosing cholangitis and ulcerative colitis: evidence for increased neoplastic potential. Hepatology. 1995;22(5):1404‐1408. PubMed

Fevery J, Henckaerts L, Van Oirbeek R, et al. Malignancies and mortality in 200 patients with primary sclerosering cholangitis: a long‐term single‐centre study. Liver Int. 2012;32(2):214‐222. PubMed

Navaneethan U, Kochhar G, Venkatesh PGK, et al. Duration and severity of primary sclerosing cholangitis is not associated with risk of neoplastic changes in the colon in patients with ulcerative colitis. Gastrointest Endosc. 2012;75(5):1045‐1054.e1. PubMed

Dyson JK. Colorectal cancer in inflammatory bowel disease: what is the real magnitude of the risk? World J Gastroenterol. 2012;18(29):3839‐3848. PubMed PMC

Mooiweer E, van der Meulen‐de Jong AE, Ponsioen CY, et al. Chromoendoscopy for surveillance in inflammatory bowel disease does not increase neoplasia detection compared with conventional colonoscopy with random biopsies: results from a large retrospective study. Am J Gastroenterol. 2015;110(7):1014‐1021. PubMed

Deneau MR, El‐Matary W, Valentino PL, et al. The natural history of primary sclerosing cholangitis in 781 children: a multicenter, international collaboration. Hepatology. 2017;66(2):518‐527. PubMed

Joosse ME, Haisma SM, Sterk MFM, et al. Disease progression in paediatric‐ and adult‐onset sclerosing cholangitis: results from two independent Dutch registries. Liver Int. 2019;39(9):1768‐1775. PubMed

Hensel KO, Kyrana E, Hadzic N, et al. Sclerosing cholangitis in pediatric inflammatory bowel disease: early diagnosis and management affect clinical outcome. J Pediatr. 2021;238:50‐56.e3. PubMed

Charatcharoenwitthaya P, Lindor KD. Primary sclerosing cholangitis: diagnosis and management. Curr Gastroenterol Rep. 2006;8(1):75‐82. PubMed

Beuers U, Spengler U, Kruis W, et al. Ursodeoxycholic acid for treatment of primary sclerosing cholangitis: a placebo‐controlled trial. Hepatology. 1992;16(3):707‐714. PubMed

Chazouillères O, Poupon R, Capron JP, et al. Ursodeoxycholic acid for primary sclerosing cholangitis. J Hepatol. 1990;11(1):120‐123. PubMed

Lindor KD. Ursodiol for primary sclerosing cholangitis. N Engl J Med. 1997;336(10):691‐695. PubMed

Olsson R, Boberg KM, Schaffalitsky de Muckadell O, et al. High‐dose ursodeoxycholic acid in primary sclerosing cholangitis: a 5‐year multicenter, randomized, controlled study. Gastroenterology. 2005;129(5):1464‐1472. PubMed

Lindor KD, Kowdley KV, Harrison EM, et al. ACG clinical guideline: primary sclerosing cholangitis. Am J Gastroenterol. 2015;110(5):646‐659. PubMed

Lindor KD, Kowdley KV, Luketic VAC, et al. High‐dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis. Hepatology. 2009;50(3):808‐814. PubMed PMC

Ali AH, Carey EJ, Lindor KD. Current research on the treatment of primary sclerosing cholangitis. Intractable Rare Dis Res. 2015;4(1):1‐6. PubMed PMC

Ali AH, Damman J, Shah SB, et al. Open‐label prospective therapeutic clinical trials: oral vancomycin in children and adults with primary sclerosing cholangitis. Scand J Gastroenterol. 2020;55(8):941‐950. PubMed

Buness C, Lindor KD, Miloh T. Oral vancomycin therapy in a child with primary sclerosing cholangitis and severe ulcerative colitis. Pediatr Gastroenterol Hepatol Nutr. 2016;19(3):210‐213. PubMed PMC

Davies YK, Tsay CJ, Caccamo DV, Cox KM, Castillo RO, Cox KL. Successful treatment of recurrent primary sclerosing cholangitis after orthotopic liver transplantation with oral vancomycin. Case Rep Transplant. 2013;2013:314292. PubMed PMC

Deneau MR, Mack C, Mogul D, et al. Oral vancomycin, ursodeoxycholic acid, or no therapy for pediatric primary sclerosing cholangitis: a matched analysis. Hepatology. 2021;73(3):1061‐1073. PubMed PMC

Lindor KD. New treatment strategies for primary sclerosing cholangitis. Dig Dis. 2011;29(1):113‐116. PubMed

Mieli‐Vergani G, Vergani D. Unique features of primary sclerosing cholangitis in children. Curr Opin Gastroenterol. 2010;26(3):265‐268. PubMed

Rahimpour S, Nasiri‐Toosi M, Khalili H, Daryani NE, Taromlou MKN, Azizi Z. A triple blinded, randomized, placebo‐controlled clinical trial to evaluate the efficacy and safety of oral vancomycin in primary sclerosing cholangitis: a pilot study. J Gastrointest Liver Dis. 2016;25(4):457‐464. PubMed

Tabibian JH, Weeding E, Jorgensen RA, et al. Randomised clinical trial: vancomycin or metronidazole in patients with primary sclerosing cholangitis – a pilot study. Aliment Pharmacol Ther. 2013;37(6):604‐612. PubMed

Karemera M, Verce M, Roumain M, et al. Pediatric autoimmune or primary sclerosing cholangitis: metronidazole effectiveness on biochemical data, bile acid profile, and gut microbiota: a pilot study. JPGN Rep. 2023;4(3):e334. PubMed PMC

Bogatic D, Bryant RV, Lynch KD, Costello SP. Systematic review: microbial manipulation as therapy for primary sclerosing cholangitis. Aliment Pharmacol Ther. 2023;57(1):23‐36. PubMed PMC

Shah A, Crawford D, Burger D, et al. Effects of antibiotic therapy in primary sclerosing cholangitis with and without inflammatory bowel disease: a systematic review and meta‐analysis. Semin Liver Dis. 2019;39(4):432‐441. PubMed

Färkkilä M, Karvonen AL, Nurmi H, et al. Metronidazole and ursodeoxycholic acid for primary sclerosing cholangitis: a randomized placebo‐controlled trial. Hepatology. 2004;40(6):1379‐1386. PubMed

Jang HJ, Kang B, Choe BH. The difference in extraintestinal manifestations of inflammatory bowel disease for children and adults. Transl Pediatr. 2019;8(1):4‐15. PubMed PMC

Kugathasan S, Miranda A, Nocton J, Drolet BA, Raasch C, Binion DG. Dermatologic manifestations of Crohn disease in children: response to infliximab. J Pediatr Gastroenterol Nutr. 2003;37(2):150‐154. PubMed

Neri B, Mossa M, Salvatori S, et al. Hidradenitis suppurativa and inflammatory bowel disease in a nested case‐control study. Dig Liver Dis. 2023;55(4):490‐495. PubMed

Miele E, Shamir R, Aloi M, et al. Nutrition in pediatric inflammatory bowel disease: a position paper on behalf of the Porto Inflammatory Bowel Disease Group of the European Society of Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr. 2018;66(4):687‐708. PubMed

Schmidt S, Mellström D, Norjavaara E, Sundh VS, Saalman R. Low bone mineral density in children and adolescents with inflammatory bowel disease: a population‐based study from Western Sweden. Inflamm Bowel Dis. 2009;15(12):1844‐1850. PubMed

Guz‐Mark A, Rinawi F, Egotubov O, Shimon I, Shamir R, Assa A. Pediatric‐onset inflammatory bowel disease poses risk for low bone mineral density at early adulthood. Dig Liver Dis. 2017;49(6):639‐642. PubMed

Levy‐Shraga Y, Megnazi O, Modan‐Moses D, et al. Trabecular bone score in children and adolescents with inflammatory bowel diseases. J Clin Densitom. 2021;24(2):243‐251. PubMed

Gokhale R, Favus MJ, Karrison T, Sutton MM, Rich B, Kirschner BS. Bone mineral density assessment in children with inflammatory bowel disease. Gastroenterology. 1998;114(5):902‐911. PubMed

Sylvester FA, Wyzga N, Hyams JS, et al. Natural history of bone metabolism and bone mineral density in children with inflammatory bowel disease. Inflamm Bowel Dis. 2007;13(1):42‐50. PubMed

Walther F, Fusch C, Radke M, Beckert S, Findeisen A. Osteoporosis in pediatric patients suffering from chronic inflammatory bowel disease with and without steroid treatment. J Pediatr Gastroenterol Nutr. 2006;43(1):42‐51. PubMed

Bąk‐Drabik K, Adamczyk P, Chobot A, Kwiecień J, Pluskiewicz W. Bone status assessed by quantitative ultrasound in children with inflammatory bowel disease: a comparison with DXA. Expert Rev Gastroenterol Hepatol. 2016;10(11):1305‐1312. PubMed

Arvanitis M, Hart LC, DeWalt DA, et al. Transition readiness not associated with measures of health in youth with IBD. Inflamm Bowel Dis. 2021;27(1):49‐57. PubMed PMC

Carrara FSA, Piotto DGP, Silva II, et al. Factors related to the readiness of Brazilian chronic pediatric patients to transition to care in adult clinics. J Pediatr. 2023;99(3):254‐262. PubMed PMC

Johnson LE, Lee MJ, Turner‐Moore R, et al. Systematic review of factors affecting transition readiness skills in patients with inflammatory bowel disease. J Crohns Colitis. 2021;15(6):1049‐1059. PubMed

Carlsen K, Haddad N, Gordon J, et al. Self‐efficacy and resilience are useful predictors of transition readiness scores in adolescents with inflammatory bowel diseases. Inflamm Bowel Dis. 2017;23(3):341‐346. PubMed

Corsello A, Pugliese D, Bracci F, et al. Transition of inflammatory bowel disease patients from pediatric to adult care: an observational study on a joint‐visits approach. Ital J Pediatr. 2021;47(1):18. PubMed PMC

van Gaalen MA, van Pieterson M, Waaijenberg P, et al. Effectiveness of transitional care in inflammatory bowel disease; development, validation, and initial outcomes of a transition success score. J Crohns Colitis. 2025;19(4):jjae166. PubMed PMC

van Rheenen PF, Aloi M, Biron IA, et al. European Crohn's and Colitis Organisation topical review on transitional care in inflammatory bowel disease. J Crohns Colitis. 2017;11(9):1032‐1038. PubMed

Benchimol EI, Afif W, Plamondon S, Newhook D, Nicholls SG, Lévesque D. Medical summary template for the transfer of patients with inflammatory bowel disease from pediatric to adult care. J Can Assoc Gastroenterol. 2022;5(1):3‐11. PubMed PMC

Fu N, Bollegala N, Jacobson K, et al. Canadian consensus statements on the transition of adolescents and young adults with inflammatory bowel disease from pediatric to adult care: a collaborative initiative between the Canadian IBD Transition Network and Crohn's and Colitis Canada. J Can Assoc Gastroenterol. 2022;5(3):105‐115. PubMed PMC

Gray WN, Holbrook E, Dykes D, Morgan PJ, Saeed SA, Denson LA. Improving IBD transition, self‐management, and disease outcomes with an in‐clinic transition coordinator. J Pediatr Gastroenterol Nutr. 2019;69(2):194‐199. PubMed

Scaldaferri F, Angelino G, Romeo EF, et al. A transition clinic model for inflammatory bowel disease between two tertiary care centers: outcomes and predictive factors. Eur Rev Med Pharmacol Sci. 2020;24(16):8469‐8476. PubMed

Gray WN, Wagoner ST, Schaefer MR, et al. Transition to adult IBD care: a pilot multi‐site, telehealth hybrid intervention. J Pediatr Psychol. 2021;46(1):1‐11. PubMed PMC

Huang JS, Yueh R, Wood K, et al. Harnessing the electronic health record to distribute transition services to adolescents with inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2020;70(2):200‐204. PubMed

Otto C, Tárnok A, Erős A, et al. Planned transition of adolescent patients with inflammatory bowel disease results in higher remission rates. J Pediatr Nurs. 2019;45:62‐66. PubMed

Arp L, Jansson S, Wewer V, Burisch J. Psychiatric disorders in adult and paediatric patients with inflammatory bowel diseases—a systematic review and meta‐analysis. J Crohn's Colitis. 2022;16(12):1933‐1945. PubMed

Knowles SR, Graff LA, Wilding H, Hewitt C, Keefer L, Mikocka‐Walus A. Quality of life in inflammatory bowel disease: a systematic review and meta‐analyses – part I. Inflamm Bowel Dis. 2018;24(4):742‐751. PubMed

Lund K, Knudsen T, Kjeldsen J, et al. Health‐related quality of life, anxiety, and self‐image in young patients with Crohn's disease and ulcerative colitis. JPGN Rep. 2023;4(1):e287. PubMed PMC

Thavamani A, Umapathi KK, Khatana J, Gulati R. Burden of psychiatric disorders among pediatric and young adults with inflammatory bowel disease: a population‐based analysis. Pediatr Gastroenterol Hepatol Nutr. 2019;22(6):527‐535. PubMed PMC

Mikocka‐Walus A, Knowles SR, Keefer L, Graff L. Controversies revisited: a systematic review of the comorbidity of depression and anxiety with inflammatory bowel diseases. Inflamm Bowel Dis. 2016;22(3):752‐762. PubMed

Cooney R, Tang D, Barrett K, Russell RK. Children and young adults with inflammatory bowel disease have an increased incidence and risk of developing mental health conditions: a UK population‐based cohort study. Inflamm Bowel Dis. 2024;30(8):1264‐1273. PubMed PMC

Arruda JM, Bogetz AL, Vellanki S, Wren A, Yeh AM. Yoga as adjunct therapy for adolescents with inflammatory bowel disease: a pilot clinical trial. Complement Ther Med. 2018;41:99‐104. PubMed

Spekhorst LM, Hummel TZ, Benninga MA, van Rheenen PF, Kindermann A. Adherence to oral maintenance treatment in adolescents with inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2016;62(2):264‐270. PubMed

Cooney R, Barrett K, Russell RK. Impact of mental health comorbidity in children and young adults with inflammatory bowel disease: a UK population‐based cohort study. BMJ Open. 2024;14(2):e080408. PubMed PMC

Wu YY, Luo YY, Huang LF, et al. Prevalence and risk factors of medication non‐adherence in children with inflammatory bowel disease. Zhonghua er ke za zhi = Chin J Pediatr. 2022;60(11):1191‐1195. PubMed

Dijkstra A, Touw DJ, Van Rheenen PF. Simple urine test to evaluate adherence to oral 5‐ASA in teenagers with ulcerative colitis: proof of concept. J Pediatr Gastroenterol Nutr. 2017;65(4):416‐419. PubMed

Gohil S, Majd Z, Sheneman JC, et al. Interventions to improve medication adherence in patients with inflammatory bowel disease: a systematic review. Pharmacoepidemiol Drug Safety. 2020;29(suppl 3):123.

Hommel KA, Ramsey RR, Gray WN, Denson LA. Digital therapeutic self‐management intervention in adolescents with inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2023;76(1):38‐42. PubMed PMC

Varni JW, Shulman RJ, Self MM, et al. Perceived medication adherence barriers mediating effects between gastrointestinal symptoms and health‐related quality of life in pediatric inflammatory bowel disease. Qual Life Res. 2018;27(1):195‐204. PubMed

Hommel KA, McGrady ME, Peugh J, et al. Longitudinal patterns of medication nonadherence and associated health care costs. Inflamm Bowel Dis. 2017;23(9):1577‐1583. PubMed PMC

Samson CM, Mager D, Frazee S, Yu F. Remission in pediatric inflammatory bowel disease correlates with prescription refill adherence rates. J Pediatr Gastroenterol Nutr. 2017;64(4):575‐579. PubMed

Jagt JZ, van Schie DA, Benninga MA, van Rheenen PF, de Boer NKH, de Meij TGJ. Endoscopic surveillance for colorectal cancer in pediatric ulcerative colitis: a survey among Dutch pediatric gastroenterologists. JPGN Rep. 2023;4(3):e341. PubMed PMC

Malham M, Jansson S, Malmborg P, et al. Risk factors of cancer in pediatric‐onset inflammatory bowel disease in Denmark and Finland. J Pediatr Gastroenterol Nutr. 2023;77(1):55‐61. PubMed

Elmahdi R, Lemser CE, Thomsen SB, Allin KH, Agrawal M, Jess T. Development of cancer among patients with pediatric‐onset inflammatory bowel disease: a meta‐analysis of population‐based studies. JAMA Netw Open. 2022;5(3):e220595. PubMed PMC

Kim MJ, Ko JS, Shin M, et al. Colorectal cancer associated with pediatric inflammatory bowel disease: a case series. BMC Pediatr. 2021;21(1):504. PubMed PMC

El‐Matary W, Guthery SL, Amir AZ, et al. Colorectal dysplasia and cancer in pediatric‐onset ulcerative colitis associated with primary sclerosing cholangitis. Clin Gastroenterol Hepatol. 2021;19(5):1067‐1070.e2. PubMed PMC

Boonstra K, Weersma RK, van Erpecum KJ, et al. Population‐based epidemiology, malignancy risk, and outcome of primary sclerosing cholangitis. Hepatology. 2013;58(6):2045‐2055. PubMed

Björnsson E, Angulo P. Cholangiocarcinoma in young individuals with and without primary sclerosing cholangitis. Am J Gastroenterol. 2007;102(8):1677‐1682. PubMed

Ali AH, Tabibian JH, Nasser‐Ghodsi N, et al. Surveillance for hepatobiliary cancers in patients with primary sclerosing cholangitis. Hepatology. 2018;67(6):2338‐2351. PubMed

Tan N, Ngu N, Worland T, et al. Surveillance MRI is associated with improved survival in patients with primary sclerosing cholangitis. Hepatol Commun. 2024;8(5):e0442. PubMed PMC

Administration USFD .

Din S, Segal J, Blackwell J, Gros B, Black CJ, Ford AC. Harms with placebo in trials of biological therapies and small molecules as induction therapy in inflammatory bowel disease: a systematic review and meta‐analysis. Lancet Gastroenterol Hepatol. 2024;9(11):1020‐1029. PubMed

Gros B, Blackwell J, Segal J, Black CJ, Ford AC, Din S. Harms with placebo in trials of biological therapies and small molecules as maintenance therapy in inflammatory bowel disease: a systematic review and meta‐analysis. Lancet Gastroenterol Hepatol. 2024;9(11):1030‐1040. PubMed

Rutgeerts P, Sandborn WJ, Feagan BG, et al. Infliximab for induction and maintenance therapy for ulcerative colitis. N Engl J Med. 2005;353(23):2462‐2476. PubMed

Baumgart DC, Le Berre C. Newer biologic and small‐molecule therapies for inflammatory bowel disease. N Engl J Med. 2021;385(14):1302‐1315. PubMed

Kapoor A, Crowley E. Advances in therapeutic drug monitoring in biologic therapies for pediatric inflammatory bowel disease. Front Pediatr. 2021;9:661536. PubMed PMC

Hudson AS, Isaac DM, Ma H, et al. Four intestinal ultrasound scores and bowel wall thickness alone correlated well with pediatric ulcerative colitis disease activity. J Pediatr Gastroenterol Nutr. 2024;79(5):1000‐1008. PubMed