Steady-state of azathioprine during initiation treatment of pediatric inflammatory bowel disease
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
21122571
DOI
10.1016/j.crohns.2010.06.005
PII: S1873-9946(10)00095-4
Knihovny.cz E-zdroje
- MeSH
- azathioprin metabolismus farmakokinetika terapeutické užití MeSH
- dítě MeSH
- genotyp MeSH
- guaninnukleotidy krev farmakokinetika MeSH
- idiopatické střevní záněty farmakoterapie enzymologie MeSH
- imunosupresiva metabolismus farmakokinetika terapeutické užití MeSH
- lidé MeSH
- merkaptopurin analogy a deriváty krev metabolismus farmakokinetika MeSH
- methyltransferasy genetika metabolismus MeSH
- mladiství MeSH
- předškolní dítě MeSH
- prospektivní studie MeSH
- stupeň závažnosti nemoci MeSH
- thionukleotidy krev farmakokinetika MeSH
- výsledek terapie MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- 6-methylthiopurine MeSH Prohlížeč
- 6-thioguanylic acid MeSH Prohlížeč
- azathioprin MeSH
- guaninnukleotidy MeSH
- imunosupresiva MeSH
- merkaptopurin MeSH
- methyltransferasy MeSH
- thionukleotidy MeSH
- thiopurine methyltransferase MeSH Prohlížeč
BACKGROUND AND AIM: Azathioprine (AZA) has a slow onset of action in treatment of pediatric inflammatory bowel disease (IBD). It is anticipated, that this delay correlates to the kinetics of 6-thioguanine nucleotides (6-TGN) accumulation. The aim of this study was to evaluate the time to steady state of 6-TGN concentration in red blood cells. METHODS: The inclusion criteria were: a) age 0-19 years b) IBD diagnosis c) AZA treatment initiation. High performance liquid chromatography was used for the 6-TGN analysis. Concentrations of metabolites were studied in weeks 0, 1, 2, 5, and 8 after beginning of treatment. RESULTS: The inclusion criteria were matched to 18 patients with IBD. The median time to steady state of 6-TGN was 55.3 days. The mean 6-TGN concentration at the steady state achieved 326 (SD 154) pmol/8.108 erythrocytes. High erythrocyte TPMT activity corresponds to the low steady state 6-TGN concentration and vice versa. This correlation reached statistical significance (p<0.01) for the dose expressed in mg per square meter of body surface area. CONCLUSION: The time to steady state of 6-TGN erythrocyte concentration is significantly shorter than would expected according to clinical observation describe earlier.
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