A perilipin that is expressed by many different cell types. It binds FATTY ACIDS and CHOLESTEROL, stabilizes TRIGLYCERIDES, and localizes to both the surface and hydrophobic core of LIPID DROPLETS, as well as the ENDOPLASMIC RECTICULUM and PLASMA MEMBRANE in MACROPHAGES. It also plays a central role in the biogenesis of lipid droplets and FOAM CELLS and is highly expressed by macrophages at atherosclerotic lesions in human arteries along with the INFLAMMATION markers TNF-ALPHA; MCP-1 RECEPTOR; and IL-6.

DUI

D000070780 MeSH Prohlížeč

CUI

M0298231

Historická pozn.

2017 (1998)

Veřejná pozn.

2017; PERILIPIN-2 was indexed under PEPTIDES 1998-2011; and under MEMBRANE PROTEINS 2011-2016