Tumor Suppressor p53-Binding Protein 1 [53BP1]
- Terms
-
nádorově supresorový protein p53
tumor suppressor p53-binding protein 1
-
53BP1 Protein
p202 Protein
TP53BP1 Protein
Tumor Protein p53-Binding Protein, 1
A nuclear and cytoplasmic protein that associates with KINETOCHORES and contains a C-terminal TUDOR DOMAIN. It plays a critical role in the cellular response to DNA DAMAGE and localizes to DOUBLE-STRAND DNA BREAKS. It may also function in M PHASE CELL CYCLE CHECKPOINTS and as an enhancer of TUMOR SUPPRESSOR PROTEIN P53-mediated transcriptional activation.
- DUI
- D000071857 MeSH Browser
- CUI
- M000615636
- Previous indexing
- Intracellular Signaling Peptides and Proteins (2005-2016); Chromosomal Proteins, Non-Histone (2005-2016); DNA-Binding Proteins (2005-2016)
- History note
- 2017
- Public note
- 2017
Allowable subheadings
- AD
- administration & dosage
- AE
- adverse effects
- AG
- agonists
- AN
- analysis
- AI
- antagonists & inhibitors
- BI
- biosynthesis
- BL
- blood
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry 2
- CL
- classification
- DF
- deficiency
- DE
- drug effects
- EC
- economics
- GE
- genetics 8
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism 14
- PK
- pharmacokinetics
- PD
- pharmacology
- PH
- physiology
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use
- TO
- toxicity
- UL
- ultrastructure
- UR
- urine
TP53BP1 protein, human Chemical MeSH Browser
Trp53bp1 protein, mouse Chemical MeSH Browser