A patched receptor for several HEDGEHOG PROTEINS that associates with the SMOOTHENED RECEPTOR to modulate hedgehog signaling. It is also a TUMOR SUPPRESSOR PROTEIN; mutations in the patched-1 gene are associated with BASAL CELL NEVUS SYNDROME; SQUAMOUS CELL CARCNIOMA of the ESOPHAGUS; trichoepitheliomas, and CARCINOMA, TRANSITIONAL CELL of the URINARY BLADDER.

DUI

D000072081 MeSH Prohlížeč

CUI

M000616305

Historická pozn.

2017 (1996)

Veřejná pozn.

2017; PATCHED-1 RECEPTOR was indexed under RECEPTORS, CELL SURFACE 2005-2016, and under MEMBRANE PROTEINS 1996-2005