P-type ATPases [ATPasy typu P]
- Terms
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ATPasa typu P
ATPáza typu P
ATPázy typu P
E1-E2 ATPasa
E1-E2 ATPasy
E1-E2 ATPáza
E1-E2 ATPázy
P-ATPasa
P-ATPasy
P-ATPázy
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E1-E2 ATPase
E1-E2 ATPases
P Type Atpase
P-type Adenosine Triphosphatase
P-type Adenosine Triphosphatases
P-type ATPase
Phosphorylation-type Adenosine Triphosphatases
Phosphorylation-type ATPases
A highly conserved family of ATPases that facilitate the transport of lipids and cations across the plasma membrane. Structurally, they are elongated ALPHA-HELICES constituting five functionally distinct domains: three cytoplasmic domains A, N, and P which contain the catalytic sites, and two transmembrane domains. The N domain phosphorylates the P-domain at an invariant ASPARTATE residue, which, in turn, is dephosphorylated by the A domain. The phosphorylation and dephosphorylation cycles drive conformational changes in the protein between two states (E1 and E2), which allow the substrate to access the other side of the membrane.
- DUI
- D000073779 MeSH Browser
- CUI
- M000623906
- Previous indexing
- Adenosine Triphosphatases (1992-2017)
- History note
- 2018
- Public note
- 2018
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