Thyroid Nuclear Factor 1 [tyreoidální jaderný faktor 1]

topical
Terms

protein TITF-1
protein TITF1
tyreoidální transkripční faktor 1

 

Homeobox Protein Nkx-2.1
NK2 Homeobox 1 Protein
Thyroid Transcription Factor 1
Thyroid-Specific Enhancer-Binding Protein
TITF-1 Protein
TITF1 Protein
TTF-1 Thyroid Nuclear Factor

Persistent link   https://www.medvik.cz/link/D000074482
Definition

A homeobox protein and transcription factor that localizes to the cell nucleus where it activates expression of thyroid specific genes such as THYROGLOBULIN and the THYROTROPIN RECEPTOR. It is critical for maintaining thyroid tissue in a differentiated state and also plays a role in lung development. Mutations in the NKX2-1 gene are associated with CHOREA, BENIGN HEREDITARY.

DUI
D000074482 MeSH Browser
CUI
M0181663
History note
2018 (1990)
Public note
2018; THYROID NUCLEAR FACTOR 1 was indexed under NUCLEAR PROTEINS and TRANSCRIPTION FACTORS 1990-2017

Allowable subheadings

AD
administration & dosage 0
AE
adverse effects 0
AG
agonists 0
AN
analysis 0
AI
antagonists & inhibitors 0
BI
biosynthesis 0
BL
blood 0
CF
cerebrospinal fluid 0
CS
chemical synthesis 0
CH
chemistry 0
CL
classification 0
DF
deficiency 0
DE
drug effects 0
EC
economics 0
GE
genetics 0
HI
history 0
IM
immunology 0
IP
isolation & purification 0
ME
metabolism 0
PK
pharmacokinetics 0
PD
pharmacology 0
PH
physiology 0
PO
poisoning 0
RE
radiation effects 0
ST
standards 0
SD
supply & distribution 0
TU
therapeutic use 0
TO
toxicity 0
UL
ultrastructure 0
UR
urine 0

D Chemicals and Drugs
D12 Amino Acids, Peptides, and Proteins 16
D12.776 Proteins 2 575
D12.776.260 DNA-Binding Proteins 556
D12.776.260.400 Homeodomain Proteins 122
D12.776.260.400.124 Antennapedia Homeodomain Protein 1
D12.776.260.400.140 CDX2 Transcription Factor 3
D12.776.260.400.155 Fushi Tarazu Transcription Factors
D12.776.260.400.186 Goosecoid Protein 2
D12.776.260.400.218 Hepatocyte Nuclear Factor 1 1
D12.776.260.400.226 Homeobox A10 Proteins
D12.776.260.400.228 Homeobox Protein PITX2
D12.776.260.400.230 Homeobox Protein Nkx-2.2
D12.776.260.400.234 Homeobox Protein Nkx-2.5 1
D12.776.260.400.242 Homeobox Protein SIX3
D12.776.260.400.249 MADS Domain Proteins 3
D12.776.260.400.436 MSX1 Transcription Factor 8
D12.776.260.400.483 Myeloid Ecotropic Viral Integration Site 1 Protein 1
D12.776.260.400.530 Nanog Homeobox Protein 3
D12.776.260.400.624 Onecut Transcription Factors
D12.776.260.400.718 Otx Transcription Factors 4
D12.776.260.400.812 PAX7 Transcription Factor 2
D12.776.260.400.836 Pre-B-Cell Leukemia Transcription Factor 1 2
D12.776.260.400.848 Prospero-Related Homeobox 1 Protein
D12.776.260.400.859 Short Stature Homeobox Protein 8
D12.776.260.400.871 Thyroid Nuclear Factor 1
D12.776.260.400.883 Zinc Finger E-box Binding Homeobox 2 3
D12.776.260.400.906 Zinc Finger E-box-Binding Homeobox 1 6
D12.776.660 Nuclear Proteins 452
D12.776.660.049 Antennapedia Homeodomain Protein 1
D12.776.660.075 Ataxins 2
D12.776.660.100 BRCA1 Protein 101
D12.776.660.105 BRCA2 Protein 95
D12.776.660.167 CCAAT-Enhancer-Binding Proteins 11
D12.776.660.201 CDX2 Transcription Factor 3
D12.776.660.235 Chromosomal Proteins, Non-Histone 93
D12.776.660.264 Fanconi Anemia Complementation Group A Protein 1
D12.776.660.285 Fanconi Anemia Complementation Group D2 Protein 4
D12.776.660.289 Fanconi Anemia Complementation Group E Protein
D12.776.660.293 Fanconi Anemia Complementation Group F Protein
D12.776.660.323 Fanconi Anemia Complementation Group N Protein 4
D12.776.660.338 GADD45 Proteins
D12.776.660.352 Hepatocyte Nuclear Factors 5
D12.776.660.415 Homeobox Protein Nkx-2.2
D12.776.660.478 Host Cell Factor C1 2
D12.776.660.486 Immunoglobulin J Recombination Signal Sequence-Binding Protein
D12.776.660.494 Inhibitor of Growth Protein 1
D12.776.660.502 Karyopherins 9
D12.776.660.526 Mad2 Proteins 1
D12.776.660.551 Mediator Complex 5
D12.776.660.600 NF-kappa B 215
D12.776.660.625 Antigens, Nuclear 11
D12.776.660.650 Nuclear Matrix-Associated Proteins 2
D12.776.660.675 Nuclear Receptor Coactivators 6
D12.776.660.688 Nuclear Receptor Interacting Protein 1 3
D12.776.660.691 Nucleolin
D12.776.660.694 Nucleophosmin 17
D12.776.660.700 Oncogene Protein p55(v-myc) 1
D12.776.660.720 Poly-ADP-Ribose Binding Proteins 5
D12.776.660.740 Proliferating Cell Nuclear Antigen 60
D12.776.660.745 Promyelocytic Leukemia Protein 4
D12.776.660.750 Protamines 42
D12.776.660.760 Proto-Oncogene Proteins c-fos 61
D12.776.660.763 Proto-Oncogene Proteins c-jun 17
D12.776.660.764 Proto-Oncogene Proteins c-mdm2 65
D12.776.660.765 Proto-Oncogene Proteins c-myc 66
D12.776.660.767 Proto-Oncogene Proteins c-rel 2
D12.776.660.768 ran GTP-Binding Protein 4
D12.776.660.769 Retinoblastoma Binding Proteins 3
D12.776.660.770 Retinoblastoma-Like Protein p107 4
D12.776.660.794 Retinoblastoma-Like Protein p130 5
D12.776.660.807 Retinoblastoma Protein 52
D12.776.660.820 Silent Information Regulator Proteins, Saccharomyces cerevisiae
D12.776.660.823 Thyroid Nuclear Factor 1
D12.776.660.912 Tumor Protein p73 6
D12.776.930 Transcription Factors 727
D12.776.930.100 Adenovirus E1A Proteins 5
D12.776.930.110 Adenovirus E1B Proteins 3
D12.776.930.120 Antennapedia Homeodomain Protein 1
D12.776.930.123 AIRE Protein 2
D12.776.930.125 Basic Helix-Loop-Helix Transcription Factors 61
D12.776.930.127 Basic-Leucine Zipper Transcription Factors 18
D12.776.930.130 beta Catenin 97
D12.776.930.137 BRCA1 Protein 101
D12.776.930.146 CDX2 Transcription Factor 3
D12.776.930.155 Core Binding Factors 3
D12.776.930.160 COUP Transcription Factors
D12.776.930.165 Cyclic AMP Receptor Protein 2
D12.776.930.211 E2F Transcription Factors 16
D12.776.930.213 Early Growth Response Transcription Factors 1
D12.776.930.215 Elongin
D12.776.930.216 Erythroid-Specific DNA-Binding Factors 1
D12.776.930.312 Fushi Tarazu Transcription Factors
D12.776.930.313 G-Box Binding Factors
D12.776.930.314 GATA Transcription Factors 2
D12.776.930.315 Goosecoid Protein 2
D12.776.930.317 Heat Shock Transcription Factors 1
D12.776.930.318 Hepatocyte Nuclear Factors 5
D12.776.930.320 Homeobox Protein PITX2
D12.776.930.321 Homeobox Protein Nkx-2.2
D12.776.930.324 Homeobox Protein Nkx-2.5 1
D12.776.930.325 Host Cell Factor C1 2
D12.776.930.326 I-kappa B Proteins 5
D12.776.930.327 Immunoglobulin J Recombination Signal Sequence-Binding Protein
D12.776.930.329 Inhibitor of Differentiation Proteins 2
D12.776.930.332 Interferon Regulatory Factors 11
D12.776.930.354 Interferon-Stimulated Gene Factor 3
D12.776.930.375 Kruppel-Like Transcription Factors 26
D12.776.930.386 Leucine-Responsive Regulatory Protein
D12.776.930.397 MADS Domain Proteins 3
D12.776.930.419 MDS1 and EVI1 Complex Locus Protein 2
D12.776.930.440 MSX1 Transcription Factor 8
D12.776.930.462 Myeloid Ecotropic Viral Integration Site 1 Protein 1
D12.776.930.483 Myeloid-Lymphoid Leukemia Protein 39
D12.776.930.542 Nanog Homeobox Protein 3
D12.776.930.600 NF-kappa B 215
D12.776.930.608 NFATC Transcription Factors 13
D12.776.930.612 NFI Transcription Factors 6
D12.776.930.616 Nuclear Factor 90 Proteins
D12.776.930.617 Nuclear Receptor Coactivators 6
D12.776.930.618 Nuclear Respiratory Factors
D12.776.930.640 Onecut Transcription Factors
D12.776.930.645 Orphan Nuclear Receptors 2
D12.776.930.650 Otx Transcription Factors 4
D12.776.930.680 p300-CBP Transcription Factors 5
D12.776.930.700 Paired Box Transcription Factors 21
D12.776.930.705 Peroxisome Proliferator-Activated Receptors 54
D12.776.930.710 POU Domain Factors 4
D12.776.930.712 Pre-B-Cell Leukemia Transcription Factor 1 2
D12.776.930.713 Promyelocytic Leukemia Protein 4
D12.776.930.714 B-Cell Lymphoma 3 Protein
D12.776.930.715 Proto-Oncogene Proteins c-bcl-6 3
D12.776.930.720 Proto-Oncogene Proteins c-ets 19
D12.776.930.725 Proto-Oncogene Proteins c-myb 30
D12.776.930.730 Proto-Oncogene Proteins c-rel 2
D12.776.930.760 Receptors, Aryl Hydrocarbon 133
D12.776.930.770 Receptors, Notch 20
D12.776.930.775 Receptors, Retinoic Acid 42
D12.776.930.778 Receptors, Steroid 143
D12.776.930.780 Repressor Proteins 189
D12.776.930.785 Rho Factor 12
D12.776.930.800 Sigma Factor 55
D12.776.930.806 Smad Proteins 14
D12.776.930.809 SMARCB1 Protein 15
D12.776.930.815 Snail Family Transcription Factors 4
D12.776.930.823 SOX Transcription Factors 1
D12.776.930.840 STAT Transcription Factors 23
D12.776.930.850 T-Box Domain Proteins 14
D12.776.930.875 TCF Transcription Factors 3
D12.776.930.882 TEA Domain Transcription Factors 3
D12.776.930.888 Thyroid Nuclear Factor 1
D12.776.930.900 Trans-Activators 110
D12.776.930.907 Transcription Factor AP-2 1
D12.776.930.908 Transcription Factor DP1 10
D12.776.930.919 Transcription Factor MTF-1
D12.776.930.930 Transcription Factors, General 1
D12.776.930.955 Transcriptional Elongation Factors 8
D12.776.930.960 Tristetraprolin 2
D12.776.930.969 Tumor Protein p73 6
D12.776.930.977 Winged-Helix Transcription Factors

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