Deubiquitinating Enzyme CYLD [deubikvitinizační enzym CYLD]
topical
1
- Terms
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deubiquitinační enzym CYLD
protein CYLD
protein cylindromatózy
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CYLD Protein
Cylindromatosis Protein
Deubiquitinating Enzyme Cylindromatosis
Persistent link
https://www.medvik.cz/link/D000074749
Definition
A deubiquitinase and tumor-suppressor protein that specifically cleaves LYSINE-63-linked polyubiquitin chains and also has endodeubiquitinase activity. It functions to regulate NF-KAPPA B and WNT SIGNALING PATHWAY activity, contributing to cell survival, proliferation, and differentiation. Mutations in the CYLD gene are associated with cases of FAMILIAL CYLINDROMATOSIS.
- DUI
- D000074749 MeSH Browser
- CUI
- M000627388
- Previous indexing
- Tumor Suppressor Proteins (2001-2017)
- History note
- 2018
- Public note
- 2018
Allowable subheadings
- AD
- administration & dosage 0
- AE
- adverse effects 0
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- antagonists & inhibitors 0
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- CS
- chemical synthesis 0
- CH
- chemistry 0
- CL
- classification 0
- DF
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- DE
- drug effects 0
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- economics 0
- GE
- genetics 1
- HI
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- immunology 0
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- isolation & purification 0
- ME
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- PK
- pharmacokinetics 0
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- pharmacology 0
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- physiology 0
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- poisoning 0
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- radiation effects 0
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- TU
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Occurrences in Medvik records
D
Chemicals and Drugs
D12.776.624.776.021
DCC Receptor
D12.776.624.776.418
Cystatin M
D12.776.624.776.503
Inhibitor of Growth Protein 1
D12.776.624.776.633
Patched Receptors