A forkhead box transcription factor that is expressed in the developing eyelid and during very early development of the gonad, prior to sex determination. It is essential for development of the ovary and inhibits SOX9 TRANSCRIPTION FACTOR to prevent differentiation to testes. It also induces APOPTOSIS in ovarian cells. Mutations in the FOXL2 gene are associated with BLEPHAROPHIMOSIS; Ptosis, and Epicanthus inversus (BPES with ovarian failure).

DUI

D000074842 MeSH Prohlížeč

CUI

M000628267

Předchozí užití

Forkhead Transcription Factors (2006-2017)

Historická pozn.

2018

Veřejná pozn.

2018