Saporins [saporiny]

topical
1
Terms

saporin

 

Ribosome-Inactivating Protein
RIP Ribosome-Inactivating Protein
SAP5 Protein
SAP6 Protein
Saporin
Saporin 5 Protein
Saporin 6 Protein
Saporin Protein
Saporin-S9 Protein

Persistent link   https://www.medvik.cz/link/D000076985
Definition

Type 1 ribosome-inactivating proteins derived from SAPONARIA OFFICINALIS that function through endohydrolysis of the N-glycosidic bond at single ADENOSINE residues of 28S RIBOSOMAL RNA. They are used as IMMUNOTOXINS.

DUI
D000076985 MeSH Browser
CUI
M000638939
RN
EC 3.2.2.22
History note
2019 (1985)
Public note
2019; see SAPORIN 1985-2018

Allowable subheadings

AD
administration & dosage 0
AE
adverse effects 0
AN
analysis 0
AI
antagonists & inhibitors 0
BI
biosynthesis 0
BL
blood 0
CF
cerebrospinal fluid 0
CS
chemical synthesis 0
CH
chemistry 0
CL
classification 0
DF
deficiency 0
DE
drug effects 0
EC
economics 0
GE
genetics 0
HI
history 0
IM
immunology 0
IP
isolation & purification 0
ME
metabolism 0
PK
pharmacokinetics 0
PD
pharmacology 1
PH
physiology 0
PO
poisoning 0
RE
radiation effects 0
ST
standards 0
SD
supply & distribution 0
TU
therapeutic use 1
TO
toxicity 0
UL
ultrastructure 0
UR
urine 0

D Chemicals and Drugs
D08 Enzymes and Coenzymes 7
D08.811 Enzymes 1 547
D08.811.277 Hydrolases 475
D08.811.277.450 Glycoside Hydrolases 88
D08.811.277.450.430 N-Glycosyl Hydrolases 6
D08.811.277.450.430.700 Ribosome Inactivating Proteins
D08.811.277.450.430.700.500 Ribosome Inactivating Proteins, Type 1
D08.811.277.450.430.700.500.500 Saporins 1
D12 Amino Acids, Peptides, and Proteins 16
D12.776 Proteins 2 575
D12.776.765 Plant Proteins 414
D12.776.765.710 Ribosome Inactivating Proteins
D12.776.765.710.500 Ribosome Inactivating Proteins, Type 1
D12.776.765.710.500.250 Saporins 1
D12.776.765.710.500.500 Trichosanthin

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