Progranulins [progranuliny]
- Terms
-
prekurzorový protein granulinu
progranulin
-
Acrogranin
Granulin Precursor
Granulin Precursor Protein
PC Cell-Derived Growth Factor
Proepithelin
Progranulin
Cysteine-rich, precursor glycoproteins encoded by the granulin gene (GRN). They contain granulin-repeats separated by linker sequences that are cleaved by a variety of proteases to release the individual GRANULIN PEPTIDES. The mammalian progranulin is composed of a half-granulin repeat followed by 7 granulin repeats. The mammalian GRANULINS are named PARAGRANULIN and granulin 1-7 for their order in the progranulin propeptide. Progranulin has growth-factor like effects and is expressed over a broad range of tissues. Under-expression of progranulin is linked to neurodegenerative diseases including FRONTOTEMPORAL DEMENTIA and NEURONAL CEROID LIPOFUSCINOSIS, while over-expression is linked to metabolic diseases including OBESITY, and INSULIN RESISTANCE.
- DUI
- D000077153 MeSH Browser
- CUI
- M000639461
- Previous indexing
- Intercellular Signaling Peptides and Proteins (1999-2018)
- History note
- 2019
- Public note
- 2019; GRANULIN PRECURSOR PROTEIN was indexed under INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS 2004-2018 and VIRAL PROTEINS1992-2003
Allowable subheadings
- AD
- administration & dosage 0
- AE
- adverse effects 0
- AG
- agonists 0
- AA
- analogs & derivatives 0
- AN
- analysis 0
- AI
- antagonists & inhibitors 0
- BI
- biosynthesis 0
- BL
- blood 0
- CF
- cerebrospinal fluid 1
- CS
- chemical synthesis 0
- CH
- chemistry 0
- CL
- classification 0
- DF
- deficiency 0
- EC
- economics 0
- GE
- genetics 1
- HI
- history 0
- IM
- immunology 0
- IP
- isolation & purification 0
- ME
- metabolism 0
- PK
- pharmacokinetics 0
- PD
- pharmacology 0
- PH
- physiology 0
- PO
- poisoning 0
- RE
- radiation effects 0
- ST
- standards 0
- SD
- supply & distribution 0
- TU
- therapeutic use 0
- TO
- toxicity 0
- UR
- urine 0