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Progranulins [progranuliny]

topical
5
Terms

prekurzorový protein granulinu
progranulin

 

Acrogranin
Granulin Precursor
Granulin Precursor Protein
PC Cell-Derived Growth Factor
Proepithelin
Progranulin

Persistent link   https://www.medvik.cz/link/D000077153
Definition

Cysteine-rich, precursor glycoproteins encoded by the granulin gene (GRN). They contain granulin-repeats separated by linker sequences that are cleaved by a variety of proteases to release the individual GRANULIN PEPTIDES. The mammalian progranulin is composed of a half-granulin repeat followed by 7 granulin repeats. The mammalian GRANULINS are named PARAGRANULIN and granulin 1-7 for their order in the progranulin propeptide. Progranulin has growth-factor like effects and is expressed over a broad range of tissues. Under-expression of progranulin is linked to neurodegenerative diseases including FRONTOTEMPORAL DEMENTIA and NEURONAL CEROID LIPOFUSCINOSIS, while over-expression is linked to metabolic diseases including OBESITY, and INSULIN RESISTANCE.

DUI
D000077153 MeSH Browser
CUI
M000639461
Previous indexing
Intercellular Signaling Peptides and Proteins (1999-2018)
History note
2019
Public note
2019; GRANULIN PRECURSOR PROTEIN was indexed under INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS 2004-2018 and VIRAL PROTEINS1992-2003

Allowable subheadings

AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid 1
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
EC
economics
GE
genetics 2
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine

D Chemicals and Drugs
D06 Hormones, Hormone Substitutes, and Hormone Antagonists 43
D06.472 Hormones 1 278
D06.472.699 Peptide Hormones 54
D06.472.699.009 Activins 3
D06.472.699.042 Adipokines 139
D06.472.699.077 Adrenomedullin 18
D06.472.699.094 Angiotensins 181
D06.472.699.100 Bombesin 4
D06.472.699.150 Calcitonin 516
D06.472.699.275 Gastric Inhibitory Polypeptide 46
D06.472.699.280 Gastrins 122
D06.472.699.301 Ghrelin 107
D06.472.699.322 Gonadotropins 276
D06.472.699.327 Hypothalamic Hormones 26
D06.472.699.337 Inhibins 33
D06.472.699.500 Motilin 2
D06.472.699.584 Natriuretic Peptides 190
D06.472.699.587 Pancreatic Hormones 13
D06.472.699.590 Parathyroid Hormone 355
D06.472.699.591 Parathyroid Hormone-Related Protein 9
D06.472.699.592 Peptide PHI
D06.472.699.595 Peptide YY 13
D06.472.699.631 Pituitary Hormones 92
D06.472.699.649 Placental Hormones 7
D06.472.699.682 Progranulins 5
D06.472.699.682.500 Granulins
D06.472.699.715 Relaxin 22
D06.472.699.810 Secretin 60
D06.472.699.857 Urocortins 3
D06.472.699.905 Urotensins 1
D06.472.699.952 Vasoactive Intestinal Peptide 31
D12 Amino Acids, Peptides, and Proteins 16
D12.644 Peptides 1 395
D12.644.276 Intercellular Signaling Peptides and Proteins 157
D12.644.276.024 Adipokines 139
D12.644.276.049 Agouti Signaling Protein
D12.644.276.074 Agouti-Related Protein 9
D12.644.276.100 Angiogenic Proteins 10
D12.644.276.150 Apelin 4
D12.644.276.200 CCN Intercellular Signaling Proteins 1
D12.644.276.374 Cytokines 2 176
D12.644.276.382 EGF Family of Proteins 7
D12.644.276.390 Endothelial Growth Factors 58
D12.644.276.400 Endothelins 184
D12.644.276.500 Ephrins 1
D12.644.276.624 Fibroblast Growth Factors 124
D12.644.276.671 Hedgehog Proteins 77
D12.644.276.742 Insulin-Like Peptides 1
D12.644.276.812 Kinins 37
D12.644.276.836 Kisspeptins 7
D12.644.276.854 Midkine 3
D12.644.276.857 Myokines 1
D12.644.276.860 Nerve Growth Factors 70
D12.644.276.908 Parathyroid Hormone-Related Protein 9
D12.644.276.910 Platelet-Derived Growth Factor 40
D12.644.276.917 Progranulins 5
D12.644.276.917.500 Granulins
D12.644.276.923 Semaphorins 4
D12.644.276.930 Serrate-Jagged Proteins 1
D12.644.276.942 Slit Homolog 2 Protein
D12.644.276.954 TGF-beta Superfamily Proteins 1
D12.644.276.963 Transforming Growth Factors 39
D12.776 Proteins 2 587
D12.776.467 Intercellular Signaling Peptides and Proteins 157
D12.776.467.024 Adipokines 139
D12.776.467.049 Agouti Signaling Protein
D12.776.467.074 Agouti-Related Protein 9
D12.776.467.100 Angiogenic Proteins 10
D12.776.467.150 B7 Antigens 3
D12.776.467.200 CCN Intercellular Signaling Proteins 1
D12.776.467.374 Cytokines 2 176
D12.776.467.382 EGF Family of Proteins 7
D12.776.467.390 Endothelial Growth Factors 58
D12.776.467.400 Endothelins 184
D12.776.467.500 Ephrins 1
D12.776.467.624 Fibroblast Growth Factors 124
D12.776.467.671 Hedgehog Proteins 77
D12.776.467.742 Insulin-Like Peptides 1
D12.776.467.812 Kinins 37
D12.776.467.836 Matrix Metalloproteinases, Secreted 10
D12.776.467.848 Midkine 3
D12.776.467.854 Myokines 1
D12.776.467.860 Nerve Growth Factors 70
D12.776.467.890 Parathyroid Hormone-Related Protein 9
D12.776.467.910 Platelet-Derived Growth Factor 40
D12.776.467.917 Progranulins 5
D12.776.467.917.500 Granulins
D12.776.467.923 Semaphorins 4
D12.776.467.933 Slit Homolog 2 Protein
D12.776.467.942 TGF-beta Superfamily Proteins 1
D12.776.467.948 Tolloid-Like Metalloproteinases
D12.776.467.960 Transforming Growth Factors 39
D12.776.467.984 Wnt Proteins 57
D12.776.811 Protein Precursors 132
D12.776.811.050 Amyloid beta-Protein Precursor 63
D12.776.811.070 Angiotensinogen 43
D12.776.811.185 Chromogranins 25
D12.776.811.243 Enzyme Precursors 68
D12.776.811.272 Factor V 94
D12.776.811.286 Factor VIII 318
D12.776.811.300 Fibrinogen 487
D12.776.811.420 Kininogens 7
D12.776.811.555 Procalcitonin 37
D12.776.811.690 Procollagen 35
D12.776.811.700 Proglucagon
D12.776.811.703 Progranulins 5
D12.776.811.706 Proinsulin 22
D12.776.811.800 Pro-Opiomelanocortin 21
D12.776.811.850 Tropoelastin 3
D23 Biological Factors 143
D23.529 Intercellular Signaling Peptides and Proteins 157
D23.529.024 Adipokines 139
D23.529.049 Agouti Signaling Protein
D23.529.074 Agouti-Related Protein 9
D23.529.100 Angiogenic Proteins 10
D23.529.134 Apelin 4
D23.529.168 B7 Antigens 3
D23.529.237 CCN Intercellular Signaling Proteins 1
D23.529.374 Cytokines 2 176
D23.529.382 EGF Family of Proteins 7
D23.529.390 Endothelial Growth Factors 58
D23.529.400 Endothelins 184
D23.529.500 Ephrins 1
D23.529.624 Fibroblast Growth Factors 124
D23.529.671 Hedgehog Proteins 77
D23.529.742 Insulin-Like Peptides 1
D23.529.812 Kinins 37
D23.529.831 Midkine 3
D23.529.841 Myokines 1
D23.529.850 Nerve Growth Factors 70
D23.529.890 Parathyroid Hormone-Related Protein 9
D23.529.910 Platelet-Derived Growth Factor 40
D23.529.917 Progranulins 5
D23.529.917.500 Granulins
D23.529.923 Semaphorins 4
D23.529.930 Serrate-Jagged Proteins 1
D23.529.936 Slit Homolog 2 Protein
D23.529.942 TGF-beta Superfamily Proteins 1
D23.529.948 Tolloid-Like Metalloproteinases
D23.529.960 Transforming Growth Factors 39
D23.529.984 Wnt Proteins 57

GRN protein, human Chemical MeSH Browser

Grn protein, mouse Chemical MeSH Browser

Grn protein, rat Chemical MeSH Browser

pgrn-1 protein, C elegans Chemical MeSH Browser

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