Camptothecin [kamptothecin]
- Terms
-
Camptothecine
An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.
- DUI
- D002166 MeSH Browser
- CUI
- M0003242
- CAS
- 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (S)-
- Previous indexing
- Alkaloids (1966-1972); Antineoplastic Agents (1966-1972)
- History note
- 73
- Public note
- 73
Allowable subheadings
- AD
- administration & dosage 66
- AE
- adverse effects 27
- AG
- agonists
- AA
- analogs & derivatives 98
- AN
- analysis
- AI
- antagonists & inhibitors
- BI
- biosynthesis
- BL
- blood 1
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry 4
- CL
- classification
- EC
- economics
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism
- PK
- pharmacokinetics 10
- PD
- pharmacology 35
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use 69
- TO
- toxicity 4
- UR
- urine
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