DNA Topoisomerases, Type I [DNA-topoisomerasy I]
- Terms
-
DNA topoizomerázy I
DNA topoizomerázy typu I
DNA-topoisomerasy - typ I
DNA-topoizomerasa III
DNA-topoizomerasa III alfa
DNA-topoizomerasa III beta
DNA-topoizomeráza III
DNA-topoizomeráza III alfa
DNA-topoizomeráza III beta
TOP3alfa
Topo III
TOPO IIIalfa
topoisomerasa 1
topoizomeráza I
topoizomeráza III
topoizomeráza III beta
topoizomeráza IIIalfa
topoizomeráza IIIbeta
-
DNA Nicking-Closing Protein
DNA Nicking-Closing Proteins
DNA Relaxing Enzyme
DNA Relaxing Enzymes
DNA Relaxing Protein
DNA Topoisomerase
DNA Topoisomerase I
DNA Topoisomerase III
DNA Topoisomerase III alpha
DNA Topoisomerase III beta
DNA Type 1 Topoisomerase
DNA Untwisting Enzyme
DNA Untwisting Enzymes
DNA Untwisting Protein
DNA Untwisting Proteins
TOP3 Topoisomerase
TOP3alpha
Topo III
TOPO IIIalpha
Topoisomerase I
Topoisomerase III
Topoisomerase III beta
Topoisomerase IIIalpha
Topoisomerase IIIbeta
Type I DNA Topoisomerase
DNA TOPOISOMERASES that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. DNA Topoisomerases, Type I enzymes reduce the topological stress in the DNA structure by relaxing the superhelical turns and knotted rings in the DNA helix.
- Annotation
- do not confuse entry term DNA UNTWISTING PROTEIN with DNA UNWINDING PROTEINS see DNA HELICASES; coordinate with BACTERIAL PROTEINS or ARCHAEAL PROTEINS if pertinent
- DUI
- D004264 MeSH Browser
- CUI
- M0381011
- CAS
- DNA topoisomerase
- Previous indexing
- Proteins (1966-1977); Deoxyribonucleases (1966-1977); DNA, Circular (1973-1977); Polynucleotide Synthetases (1973-1977); specific protein (1966-1977)
- History note
- 2002
- Public note
- 2002; see DNA TOPOISOMERASE 1994-2001, see DNA UNTWISTING PROTEINS 1978-1993; for DNA NICKING-CLOSING PROTEIN see DNA NICKING-CLOSING PROTEINS 1978-1993; for DNA RELAXING ENZYME see DNA RELAXING ENZYMES 1978-1993; for DNA UNTWISTING ENZYME see DNA UNTWISTING ENZYMES 1978-1993
Combination
- antagonists & inhibitors
- Topoisomerase I Inhibitors
Allowable subheadings
- AD
- administration & dosage 1
- AE
- adverse effects 0
- AN
- analysis 0
- BI
- biosynthesis 0
- BL
- blood 0
- CF
- cerebrospinal fluid 0
- CS
- chemical synthesis 0
- CH
- chemistry 3
- CL
- classification 1
- DF
- deficiency 0
- DE
- drug effects 0
- EC
- economics 0
- GE
- genetics 5
- HI
- history 0
- IM
- immunology 1
- IP
- isolation & purification 0
- ME
- metabolism 14
- PK
- pharmacokinetics 0
- PD
- pharmacology 1
- PH
- physiology 0
- PO
- poisoning 0
- RE
- radiation effects 0
- ST
- standards 0
- SD
- supply & distribution 0
- TU
- therapeutic use 3
- TO
- toxicity 0
- UL
- ultrastructure 0
- UR
- urine 0