A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.

Annotation

for physiol process only; for technique use NUCLEIC ACID AMPLIFICATION TECHNIQUES or specifics

pouze fyziologický proces; pro techniku užij deskriptor TECHNIKY AMPLIFIKACE NUKLEOVÝCH KYSELIN nebo konkrétní

DUI

D005784 MeSH Browser

CUI

M0009060

Previous indexing

Plasmids (1975-1979); Genes (1966-1967); Nucleic Acid Hybridization (1971-1979); Genes, Structural (1968-1979)

History note

80

Public note

80