Properdin [properdin]
topical
22
- Terms
-
Complement Factor P
Persistent link
https://www.medvik.cz/link/D011414
Definition
A 53-kDa protein that is a positive regulator of the alternate pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It stabilizes the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb) and protects it from rapid inactivation, thus facilitating the cascade of COMPLEMENT ACTIVATION and the formation of MEMBRANE ATTACK COMPLEX. Individuals with mutation in the PFC gene exhibit properdin deficiency and have a high susceptibility to infections.
- DUI
- D011414 MeSH Browser
- CUI
- M0017748
- CAS
- Complement factor P
Allowable subheadings
- AD
- administration & dosage 2
- AE
- adverse effects 0
- AG
- agonists 0
- AA
- analogs & derivatives 0
- AN
- analysis 2
- AI
- antagonists & inhibitors 2
- BI
- biosynthesis 2
- CF
- cerebrospinal fluid 0
- CS
- chemical synthesis 0
- CH
- chemistry 1
- CL
- classification 0
- DF
- deficiency 0
- DE
- drug effects 1
- EC
- economics 0
- GE
- genetics 0
- HI
- history 0
- IM
- immunology 0
- IP
- isolation & purification 2
- ME
- metabolism 1
- PK
- pharmacokinetics 0
- PD
- pharmacology 0
- PH
- physiology 1
- PO
- poisoning 0
- RE
- radiation effects 0
- ST
- standards 0
- SD
- supply & distribution 0
- TU
- therapeutic use 2
- TO
- toxicity 0
- UL
- ultrastructure 0
- UR
- urine 0
...
Occurrences in Medvik records
D
Chemicals and Drugs
D12.776.124.486.274.550
Complement C6
D12.776.124.486.274.650
Complement C7
D12.776.124.486.274.850
Complement C9