Tosylphenylalanyl Chloromethyl Ketone [tosylfenylalanylchlormethylketon]

topical
4
Terms

Chlorophenyltosylamidobutanone
Tosylphenylalanyl Chloromethane
TPCK

Persistent link   https://www.medvik.cz/link/D014108
Definition

An inhibitor of Serine Endopeptidases. Acts as alkylating agent and is known to interfere with the translation process.

DUI
D014108 MeSH Browser
CUI
M0021715
CAS
Benzenesulfonamide, N-(3-chloro-2-oxo-1-(phenylmethyl)propyl)-4-methyl-, (S)-
Previous indexing
Tosyl Compounds (1973-1974); Phenylalanine (1972-1974); Chlorine (1974)
History note
91(75); was see under AMINO ACID CHLOROMETHYL KETONES 1977-90; was see under PHENYLALANINE 1975-76
Public note
91; was see under AMINO ACID CHLOROMETHYL KETONES 1977-90; was see under PHENYLALANINE 1975-76

Allowable subheadings

AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology 4
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine

D Chemicals and Drugs
D02 Organic Chemicals 391
D02.065 Amides 260
D02.065.884 Sulfonamides 777
D02.065.884.060 Benzenesulfonamides 3
D02.065.884.060.003 Acetohexamide
D02.065.884.060.005 Bosentan 16
D02.065.884.060.010 Carbutamide 2
D02.065.884.060.020 Celecoxib 14
D02.065.884.060.040 Chlorpropamide 9
D02.065.884.060.050 Chlorthalidone 42
D02.065.884.060.100 Gliclazide 63
D02.065.884.060.150 Mafenide 1
D02.065.884.060.160 Sulfachlorpyridazine
D02.065.884.060.170 Sulfadiazine 28
D02.065.884.060.180 Sulfadimethoxine 3
D02.065.884.060.190 Sulfadoxine 4
D02.065.884.060.200 Sulfaguanidine 3
D02.065.884.060.210 Sulfalene
D02.065.884.060.220 Sulfamerazine 2
D02.065.884.060.230 Sulfameter 4
D02.065.884.060.240 Sulfamethazine 14
D02.065.884.060.250 Sulfamethizole 1
D02.065.884.060.300 Sulfamethoxazole 31
D02.065.884.060.325 Sulfamethoxypyridazine 9
D02.065.884.060.338 Sulfamonomethoxine 2
D02.065.884.060.344 Sulfamoxole
D02.065.884.060.350 Sulfanilamide 1
D02.065.884.060.400 Sulfaphenazole 3
D02.065.884.060.450 Sulfapyridine 4
D02.065.884.060.500 Sulfaquinoxaline
D02.065.884.060.550 Sulfathiazole 2
D02.065.884.060.600 Sulfisomidine 1
D02.065.884.060.650 Sulfisoxazole 5
D02.065.884.060.700 Tamsulosin 14
D02.065.884.060.740 Tolazamide
D02.065.884.060.745 Tolbutamide 57
D02.065.884.060.872 Tosyllysine Chloromethyl Ketone 4
D02.065.884.060.936 Tosylphenylalanyl Chloromethyl Ketone 4
D02.455 Hydrocarbons 139
D02.455.426 Hydrocarbons, Cyclic 24
D02.455.426.559 Hydrocarbons, Aromatic 50
D02.455.426.559.389 Benzene Derivatives 73
D02.455.426.559.389.085 Benzenesulfonamides 3
D02.455.426.559.389.085.003 Acetohexamide
D02.455.426.559.389.085.005 Bosentan 16
D02.455.426.559.389.085.010 Carbutamide 2
D02.455.426.559.389.085.020 Celecoxib 14
D02.455.426.559.389.085.040 Chlorpropamide 9
D02.455.426.559.389.085.050 Chlorthalidone 42
D02.455.426.559.389.085.100 Gliclazide 63
D02.455.426.559.389.085.150 Mafenide 1
D02.455.426.559.389.085.160 Sulfachlorpyridazine
D02.455.426.559.389.085.170 Sulfadiazine 28
D02.455.426.559.389.085.180 Sulfadimethoxine 3
D02.455.426.559.389.085.190 Sulfadoxine 4
D02.455.426.559.389.085.200 Sulfaguanidine 3
D02.455.426.559.389.085.210 Sulfalene
D02.455.426.559.389.085.220 Sulfamerazine 2
D02.455.426.559.389.085.230 Sulfameter 4
D02.455.426.559.389.085.240 Sulfamethazine 14
D02.455.426.559.389.085.250 Sulfamethizole 1
D02.455.426.559.389.085.300 Sulfamethoxazole 31
D02.455.426.559.389.085.325 Sulfamethoxypyridazine 9
D02.455.426.559.389.085.338 Sulfamonomethoxine 2
D02.455.426.559.389.085.344 Sulfamoxole
D02.455.426.559.389.085.350 Sulfanilamide 1
D02.455.426.559.389.085.400 Sulfaphenazole 3
D02.455.426.559.389.085.450 Sulfapyridine 4
D02.455.426.559.389.085.500 Sulfaquinoxaline
D02.455.426.559.389.085.550 Sulfathiazole 2
D02.455.426.559.389.085.600 Sulfisomidine 1
D02.455.426.559.389.085.650 Sulfisoxazole 5
D02.455.426.559.389.085.700 Tamsulosin 14
D02.455.426.559.389.085.740 Tolazamide
D02.455.426.559.389.085.745 Tolbutamide 57
D02.455.426.559.389.085.872 Tosyllysine Chloromethyl Ketone 4
D02.455.426.559.389.085.936 Tosylphenylalanyl Chloromethyl Ketone 4
D02.455.426.559.389.832 Toluene 210
D02.455.426.559.389.832.140 Bromcresol Green 3
D02.455.426.559.389.832.150 Bromcresol Purple 2
D02.455.426.559.389.832.180 Bromphenol Blue 3
D02.455.426.559.389.832.200 Bromthymol Blue 3
D02.455.426.559.389.832.500 Toluene 2,4-Diisocyanate 12
D02.455.426.559.389.832.559 Toluidines 77
D02.455.426.559.389.832.661 Tosyl Compounds 23
D02.455.426.559.389.832.670 Tosylarginine Methyl Ester 2
D02.455.426.559.389.832.690 Tosyllysine Chloromethyl Ketone 4
D02.455.426.559.389.832.710 Tosylphenylalanyl Chloromethyl Ketone 4
D02.455.426.559.389.832.767 Trifluralin 2
D02.455.426.559.389.832.868 Trinitrotoluene 20
D02.886 Sulfur Compounds 42
D02.886.590 Sulfones 123
D02.886.590.700 Sulfonamides 777
D02.886.590.700.090 Benzenesulfonamides 3
D02.886.590.700.090.003 Acetohexamide
D02.886.590.700.090.005 Bosentan 16
D02.886.590.700.090.010 Carbutamide 2
D02.886.590.700.090.020 Celecoxib 14
D02.886.590.700.090.040 Chlorpropamide 9
D02.886.590.700.090.050 Chlorthalidone 42
D02.886.590.700.090.100 Gliclazide 63
D02.886.590.700.090.150 Mafenide 1
D02.886.590.700.090.160 Sulfachlorpyridazine
D02.886.590.700.090.170 Sulfadiazine 28
D02.886.590.700.090.180 Sulfadimethoxine 3
D02.886.590.700.090.190 Sulfadoxine 4
D02.886.590.700.090.200 Sulfaguanidine 3
D02.886.590.700.090.210 Sulfalene
D02.886.590.700.090.220 Sulfamerazine 2
D02.886.590.700.090.230 Sulfameter 4
D02.886.590.700.090.240 Sulfamethazine 14
D02.886.590.700.090.250 Sulfamethizole 1
D02.886.590.700.090.300 Sulfamethoxazole 31
D02.886.590.700.090.325 Sulfamethoxypyridazine 9
D02.886.590.700.090.338 Sulfamonomethoxine 2
D02.886.590.700.090.344 Sulfamoxole
D02.886.590.700.090.350 Sulfanilamide 1
D02.886.590.700.090.400 Sulfaphenazole 3
D02.886.590.700.090.450 Sulfapyridine 4
D02.886.590.700.090.500 Sulfaquinoxaline
D02.886.590.700.090.550 Sulfathiazole 2
D02.886.590.700.090.600 Sulfisomidine 1
D02.886.590.700.090.650 Sulfisoxazole 5
D02.886.590.700.090.700 Tamsulosin 14
D02.886.590.700.090.740 Tolazamide
D02.886.590.700.090.745 Tolbutamide 57
D02.886.590.700.090.872 Tosyllysine Chloromethyl Ketone 4
D02.886.590.700.090.936 Tosylphenylalanyl Chloromethyl Ketone 4
D02.886.590.887 Tosyl Compounds 23
D02.886.590.887.140 Bromcresol Green 3
D02.886.590.887.150 Bromcresol Purple 2
D02.886.590.887.180 Bromphenol Blue 3
D02.886.590.887.200 Bromthymol Blue 3
D02.886.590.887.570 Tosylarginine Methyl Ester 2
D02.886.590.887.600 Tosyllysine Chloromethyl Ketone 4
D02.886.590.887.660 Tosylphenylalanyl Chloromethyl Ketone 4
D12 Amino Acids, Peptides, and Proteins 16
D12.125 Amino Acids 1 360
D12.125.065 Amino Acid Chloromethyl Ketones 11
D12.125.065.850 Tosyllysine Chloromethyl Ketone 4
D12.125.065.930 Tosylphenylalanyl Chloromethyl Ketone 4

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