Dideoxyadenosine [dideoxyadenosin]
- Terms
-
2',3'-dideoxyadenosin
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2',3'-Dideoxyadenosine
ddA (Antiviral)
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is an inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal side effect is nephrotoxicity. In vivo, dideoxyadenosine is rapidly metabolized to DIDANOSINE (ddI) by enzymatic deamination; ddI is then converted to dideoxyinosine monophosphate and ultimately to dideoxyadenosine triphosphate, the putative active metabolite.
- Annotation
- an antiviral; inhibits HIV replication
- DUI
- D016048 MeSH Browser
- CUI
- M0024534
- CAS
- Adenosine, 2',3'-dideoxy-
- Previous indexing
- Dideoxynucleosides (1989); Deoxyadenosine/analogs & derivatives (1975-1989)
- History note
- 90
- Public note
- 90
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