Dystrophin [dystrofin]

topical
46
Persistent link   https://www.medvik.cz/link/D016189
Definition

A muscle protein localized in surface membranes which is the product of the Duchenne/Becker muscular dystrophy gene. Individuals with Duchenne muscular dystrophy usually lack dystrophin completely while those with Becker muscular dystrophy have dystrophin of an altered size. It shares features with other cytoskeletal proteins such as SPECTRIN and alpha-actinin but the precise function of dystrophin is not clear. One possible role might be to preserve the integrity and alignment of the plasma membrane to the myofibrils during muscle contraction and relaxation. MW 400 kDa.

Annotation
a muscle protein: see MeSH definition for relation to musc dystrophy; /biosyn /drug eff /physiol /ultrastruct permitted
DUI
D016189 MeSH Browser
CUI
M0024706
Previous indexing
Muscle Proteins (1988-1990)
History note
91
Public note
91

Allowable subheadings

AD
administration & dosage 0
AE
adverse effects 0
AG
agonists 0
AN
analysis 7
AI
antagonists & inhibitors 0
BI
biosynthesis 0
BL
blood 0
CF
cerebrospinal fluid 0
CS
chemical synthesis 0
CH
chemistry 0
CL
classification 0
DF
deficiency 6
DE
drug effects 1
EC
economics 0
GE
genetics 23
HI
history 0
IM
immunology 1
IP
isolation & purification 0
ME
metabolism 3
PK
pharmacokinetics 0
PD
pharmacology 0
PH
physiology 3
PO
poisoning 0
RE
radiation effects 0
ST
standards 0
SD
supply & distribution 0
TU
therapeutic use 0
TO
toxicity 0
UL
ultrastructure 0
UR
urine 0

D Chemicals and Drugs
D12 Amino Acids, Peptides, and Proteins 16
D12.776 Proteins 2 575
D12.776.210 Contractile Proteins 27
D12.776.210.500 Muscle Proteins 133
D12.776.210.500.095 Actinin 11
D12.776.210.500.100 Actins 292
D12.776.210.500.154 Actomyosin 22
D12.776.210.500.187 Calponins 1
D12.776.210.500.220 Calsequestrin 4
D12.776.210.500.227 CapZ Actin Capping Protein
D12.776.210.500.235 Caveolin 3 1
D12.776.210.500.242 Cofilin 2
D12.776.210.500.246 Connectin 3
D12.776.210.500.248 Dysferlin
D12.776.210.500.250 Dystrophin 46
D12.776.210.500.410 Dystrophin-Associated Proteins
D12.776.210.500.570 Myogenic Regulatory Factors 6
D12.776.210.500.588 Myoglobin 139
D12.776.210.500.600 Myosins 132
D12.776.210.500.675 NAV1.4 Voltage-Gated Sodium Channel
D12.776.210.500.750 Parvalbumins 21
D12.776.210.500.775 Profilins 10
D12.776.210.500.800 Ryanodine Receptor Calcium Release Channel 44
D12.776.210.500.847 Tropomodulin 1
D12.776.210.500.895 Tropomyosin 23
D12.776.210.500.910 Troponin 263
D12.776.220 Cytoskeletal Proteins 97
D12.776.220.040 Adenomatous Polyposis Coli Protein 13
D12.776.220.145 Catenins 1
D12.776.220.148 Centrosomal Associated Proteins
D12.776.220.149 Collapsin Response Mediator Protein 1
D12.776.220.150 Cornified Envelope Proline-Rich Proteins 2
D12.776.220.250 Dystrophin 46
D12.776.220.362 Dystrophin-Associated Proteins
D12.776.220.475 Intermediate Filament Proteins 57
D12.776.220.525 Microfilament Proteins 52
D12.776.220.600 Microtubule Proteins 22
D12.776.220.790 Plakins 1
D12.776.220.885 Plakophilins 1
D12.776.220.909 Pyrin
D12.776.220.932 Septins 5
D12.776.220.980 Spectrin 20
D12.776.220.985 Talin 7
D12.776.220.987 Utrophin 1
D12.776.220.990 Vinculin 13
D12.776.220.995 Zyxin
D12.776.543 Membrane Proteins 849
D12.776.543.019 5-Lipoxygenase-Activating Proteins 1
D12.776.543.029 Amphiregulin 3
D12.776.543.039 Amyloid beta-Protein Precursor 58
D12.776.543.080 Ankyrins 10
D12.776.543.090 Arrestins 6
D12.776.543.095 B7 Antigens 3
D12.776.543.100 Bacterial Outer Membrane Proteins 92
D12.776.543.116 Bcl-2-Like Protein 11 5
D12.776.543.131 Cadherin Related Proteins 1
D12.776.543.162 Calnexin 4
D12.776.543.178 Carbonic Anhydrase IX 19
D12.776.543.193 Chemokine CX3CL1 3
D12.776.543.200 Cornified Envelope Proline-Rich Proteins 2
D12.776.543.213 Discs Large Homolog 1 Protein
D12.776.543.219 Disks Large Homolog 4 Protein 1
D12.776.543.225 Dysferlin
D12.776.543.250 Dystrophin 46
D12.776.543.268 Dystrophin-Associated Proteins
D12.776.543.277 Electron Transport Chain Complex Proteins 31
D12.776.543.287 Ephrins 1
D12.776.543.306 gp100 Melanoma Antigen 1
D12.776.543.325 Heterotrimeric GTP-Binding Proteins 14
D12.776.543.475 LDL-Receptor Related Protein-Associated Protein
D12.776.543.484 Lipid-Linked Proteins 1
D12.776.543.488 MARVEL Domain-Containing Proteins 1
D12.776.543.493 Matrix Metalloproteinases, Membrane-Associated 1
D12.776.543.512 Membrane Fusion Proteins
D12.776.543.550 Membrane Glycoproteins 200
D12.776.543.585 Membrane Transport Proteins 207
D12.776.543.602 Mitochondrial Trifunctional Protein 2
D12.776.543.620 Myelin Proteins 32
D12.776.543.637 Myristoylated Alanine-Rich C Kinase Substrate
D12.776.543.653 NADPH Oxidases 44
D12.776.543.685 Neurofibromin 2 3
D12.776.543.689 Peroxisomal Biogenesis Factor 2
D12.776.543.693 Phospholipid Transfer Proteins 6
D12.776.543.695 Pore Forming Cytotoxic Proteins 8
D12.776.543.696 Presenilins 6
D12.776.543.697 Protoporphyrinogen Oxidase 5
D12.776.543.701 Pulmonary Surfactant-Associated Protein B 4
D12.776.543.717 Pulmonary Surfactant-Associated Protein C 5
D12.776.543.725 Receptor Activity-Modifying Proteins 1
D12.776.543.733 Receptor-Like Protein Tyrosine Phosphatases
D12.776.543.750 Receptors, Cell Surface 511
D12.776.543.800 Serrate-Jagged Proteins 1
D12.776.543.850 Spectrin 20
D12.776.543.875 Stromal Interaction Molecules 3
D12.776.543.900 Tetraspanins 13
D12.776.543.930 Thylakoid Membrane Proteins 1
D12.776.543.935 Thyroid Hormone-Binding Proteins
D12.776.543.940 Tight Junction Proteins 5
D12.776.543.985 Utrophin 1
D12.776.543.990 Vesicular Transport Proteins 45

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