Mutagenesis, Insertional [inzerční mutageneze]

topical
56
Terms

genová inzerce
inzerce genu
inzerce sekvence
inzerční aktivace
inzerční mutace
inzerční mutageneze pomocí linkerů
kazetová mutageneze
mutageneze inzerční
sekvenční inzerce
virová inzerční mutageneze

 

Gene Insertion
Insertion Mutation
Insertional Activation
Insertional Mutagenesis
Linker-Insertion Mutagenesis
Mutagenesis, Cassette
Sequence Insertion
Viral Insertional Mutagenesis

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Definition

Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation.

DUI
D016254 MeSH Browser
CUI
M0024827
Previous indexing
DNA Insertion Elements (1983-1990); Mutation (1982-1990)
History note
91
Public note
91

E Analytical, Diagnostic and Therapeutic Techniques and Equipment
E05.393.420 Genetic Engineering 520
E05.393.420.601 Protein Engineering 80
E05.393.420.601.035 Amino Acid Substitution 177
E05.393.420.601.292 Cell Surface Display Techniques 4
E05.393.420.601.550 Mutagenesis, Insertional 56
E05.393.420.601.575 Mutagenesis, Site-Directed 141

G Phenomena and Processes
G05.365.590 Mutation 5 036
G05.365.590.029 Allelic Imbalance 2
G05.365.590.060 Base Pair Mismatch 14
G05.365.590.175 Chromosome Aberrations 1 578
G05.365.590.195 Codon, Nonsense 52
G05.365.590.220 DNA Repeat Expansion 7
G05.365.590.265 Frameshift Mutation 47
G05.365.590.288 Gain of Function Mutation 18
G05.365.590.310 Gene Amplification 334
G05.365.590.320 Gene Duplication 65
G05.365.590.335 Genomic Instability 88
G05.365.590.350 Germ-Line Mutation 202
G05.365.590.500 INDEL Mutation 17
G05.365.590.538 Loss of Function Mutation 13
G05.365.590.575 Mutagenesis, Insertional 56
G05.365.590.594 Mutation Accumulation 3
G05.365.590.612 Mutation Rate 18
G05.365.590.650 Mutation, Missense 216
G05.365.590.675 Point Mutation 246
G05.365.590.762 Sequence Deletion 104
G05.365.590.770 Sequence Inversion 2
G05.365.590.803 Silent Mutation 2
G05.365.590.835 Suppression, Genetic 29
G05.558 Mutagenesis 276
G05.558.315 Gene Amplification 334
G05.558.320 Gene Duplication 65
G05.558.370 INDEL Mutation 17
G05.558.800 Sequence Deletion 104
G05.558.805 Sequence Inversion 2
G05.558.835 Suppression, Genetic 29
G05.558.860 Translocation, Genetic 343