A synthetic methylprostaglandin E1 analog that reduces gastric acid secretion and enhances the gastric mucus-bicarbonate barrier. It is effective in the therapy of gastric ulcers and gives significant protection against NSAID-induced gastric mucosal damage. The drug also prevents cyclosporin A-induced damage to endocrine and exocrine pancreatic secretions. It shows a low order of acute toxicity and there is no evidence of embryotoxicity, fetotoxicity, teratogenicity, or mutagenicity in animal studies.

DUI

D016630 MeSH Browser

CUI

M0025346

CAS

Prost-13-en-9-one, 1,11,16-trihydroxy-16-methyl-, (11alpha,13E)-

Previous indexing

Anti-Ulcer Agents (1977-1991); Prostaglandins E (1975-1991); Prostaglandins, Synthetic (1977-1991)

History note

92; was RIOPROSTIL (NM) 1985-91

Online note

use RIOPROSTIL (NM) to search RIOPROSTIL 1985-91

Public note

92; RIOPROSTIL was indexed under PROSTAGLANDINS E 1985-91