A dominantly-inherited ATAXIA first described in people of Azorean and Portuguese descent, and subsequently identified in Brazil, Japan, China, and Australia. This disorder is classified as one of the SPINOCEREBELLAR ATAXIAS (Type 3) and has been associated with a mutation of the MJD1 gene on chromosome 14. Clinical features include progressive ataxia, DYSARTHRIA, postural instability, nystagmus, eyelid retraction, and facial FASCICULATIONS. DYSTONIA is prominent in younger patients (referred to as Type I Machado-Joseph Disease). Type II features ataxia and ocular signs; Type III features MUSCULAR ATROPHY and a sensorimotor neuropathy; and Type IV features extrapyramidal signs combined with a sensorimotor neuropathy. (From Clin Neurosci 1995;3(1):17-22; Ann Neurol 1998 Mar;43(3):288-96)

DUI

D017827 MeSH Browser

CUI

M0026933

Previous indexing

Cerebellar Ataxia (1980-1986); Spinocerebellar Degeneration (1986-1993)

History note

94; was see SPINOCEREBELLAR DEGENERATION 1987-93

Online note

use SPINOCEREBELLAR DEGENERATION to search MACHADO-JOSEPH DISEASE 1987-93

Public note

94; was see SPINOCEREBELLAR DEGENERATION 1987-93