Receptors, Thrombin [receptory trombinu]
- Terms
-
peptid aktivující trombinový receptor
peptidy aktivující trombinové receptory
receptor thrombinu
receptor trombinu
receptory thrombinu
TRAP
-
Thrombin Receptor
Thrombin Receptor Activating Peptide Ligand
Thrombin Receptor Activating Peptides
Thrombin Receptor Activator Peptide
Thrombin Receptors
TRAP Peptide
A family of proteinase-activated receptors that are specific for THROMBIN. They are found primarily on PLATELETS and on ENDOTHELIAL CELLS. Activation of thrombin receptors occurs through the proteolytic action of THROMBIN, which cleaves the N-terminal peptide from the receptor to reveal a new N-terminal peptide that is a cryptic ligand for the receptor. The receptors signal through HETEROTRIMERIC GTP-BINDING PROTEINS. Small synthetic peptides that contain the unmasked N-terminal peptide sequence can also activate the receptor in the absence of proteolytic activity.
- DUI
- D018179 MeSH Browser
- CUI
- M0027406
- Previous indexing
- Receptors, Cell Surface (1981-1993); Proteins (2000-2003)
- History note
- 1994; use THROMBIN RECEPTOR (NM) 1981-1993; for TRAP PEPTIDE use RECEPTORS, THROMBIN (NM) 2000-2003
- Public note
- 1994; THROMBIN RECEPTOR was indexed under RECEPTORS, ENDOGENOUS SUBSTANCES 1981-1993; TRAP PEPTIDE was indexed under PROTEINS 2000-2003
Allowable subheadings
- AD
- administration & dosage 1
- AG
- agonists
- AN
- analysis
- AI
- antagonists & inhibitors 6
- BI
- biosynthesis
- BL
- blood
- CH
- chemistry
- CL
- classification
- DF
- deficiency
- DE
- drug effects
- GE
- genetics
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism 2
- PH
- physiology 1
- RE
- radiation effects
- TU
- therapeutic use 2
- UL
- ultrastructure
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