An integrin that binds to a variety of plasma and extracellular matrix proteins containing the conserved RGD amino acid sequence and modulates cell adhesion. Integrin alphavbeta3 is highly expressed in OSTEOCLASTS where it may play role in BONE RESORPTION. It is also abundant in vascular smooth muscle and endothelial cells, and in some tumor cells, where it is involved in angiogenesis and cell migration. Although often referred to as the vitronectin receptor there is more than one receptor for vitronectin (RECEPTORS, VITRONECTIN).

Annotation

do not confuse entry term VITRONECTIN RECEPTOR with VITRONECTIN RECEPTORS

DUI

D039302 MeSH Browser

CUI

M0418730

History note

2003; use RECEPTORS, VITRONECTIN 1996-2002

Public note

2003; see RECEPTORS, VITRONECTIN 1996-2002