A dimeric cell surface receptor involved in angiogenesis (NEOVASCULARIZATION, PHYSIOLOGICAL) and AXONAL GUIDANCE. Neuropilin-1 is a 140-kDa transmembrane protein that binds CLASS 3 SEMAPHORINS, and several other growth factors. Neuropilin-1 forms complexes with plexins or VEGF RECEPTORS; their binding affinity and specificity are determined by the composition of the neuropilin dimer and the identity of other receptors complexed with it. Neuropilin-1 is expressed in distinct patterns during neural development, complementary to those described for NEUROPILIN-2.

DUI

D039942 MeSH Prohlížeč

CUI

M0191842

Předchozí užití

Nerve Tissue Proteins (1991-2002)

Historická pozn.

2003; use NEUROPILIN-1 (NM) 1991-2002

Veřejná pozn.

2003; A5 ANTIGEN (now NEUROPILIN-1) was indexed under NERVE TISSUE PROTEINS 1991-2002