Semaphorins [semaforiny]
- Terms
-
Class 1 Semaphorins
Class 2 Semaphorins
Class 3 Semaphorins
Class 4 Semaphorins
Class 5 Semaphorins
Class 6 Semaphorins
Class 7 Semaphorins
Class V Semaphorins
Sema 1
Semaphorin
Semaphorin-1
Semaphorin-2
Semaphorin-3
Semaphorin-4
Semaphorin-5
Semaphorin-6
Semaphorin-7
Semaphorin-V
A family of proteins that mediate AXONAL GUIDANCE. Semaphorins act as repulsive cues for neuronal GROWTH CONES and bind to receptors on their filopodia. At least 20 different molecules have been described and divided into eight classes based on domain organization and species of origin. Classes 1 and 2 are invertebrate, classes 3-7 are vertebrate, and class V are viral. Semaphorins may be secreted (classes 2, 3, and V), transmembrane (classes 1, 4, 5, and 6), or membrane-anchored (class 7). All semaphorins possess a common 500-amino acid extracellular domain which is critical for receptor binding and specificity, and is also found in plexins and scatter factor receptors. Their C termini are class-specific and may contain additional sequence motifs.
- DUI
- D039961 MeSH Browser
- CUI
- M0419969
- History note
- 2003; for SEMA 1 & SEMAPHORIN-1 use SEMAPHORIN 1A, GRASSHOPPER (NM) 1994-2002
- Public note
- 2003; SEMA 1 & SEMAPHORIN-1 was indexed under CELL ADHESION MOLECULES, NEURONAL 1994-2002
Allowable subheadings
- AD
- administration & dosage
- AE
- adverse effects
- AG
- agonists
- AN
- analysis
- AI
- antagonists & inhibitors
- BI
- biosynthesis
- BL
- blood 1
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry
- CL
- classification
- DF
- deficiency
- EC
- economics
- GE
- genetics 3
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism 1
- PK
- pharmacokinetics
- PD
- pharmacology
- PH
- physiology
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use
- TO
- toxicity
- UR
- urine
CD100 antigen Chemical MeSH Browser
SEMA3B protein, human Chemical MeSH Browser
SEMA3E protein, human Chemical MeSH Browser
SEMA4A protein, human Chemical MeSH Browser
SEMA5A protein, human Chemical MeSH Browser
SEMA6A protein, human Chemical MeSH Browser
SEMA6B protein, human Chemical MeSH Browser
SEMA6C protein, human Chemical MeSH Browser
SEMA6D protein, human Chemical MeSH Browser
SEMA7A protein, human Chemical MeSH Browser
Sema 3D protein, mouse Chemical MeSH Browser
Sema2b protein, Drosophila Chemical MeSH Browser
Sema3C protein, human Chemical MeSH Browser
Sema3D protein, human Chemical MeSH Browser
Sema3D protein, rat Chemical MeSH Browser
Sema3E protein, zebrafish Chemical MeSH Browser
Sema3b protein, mouse Chemical MeSH Browser
Sema3e protein, mouse Chemical MeSH Browser
Sema4A protein, mouse Chemical MeSH Browser
Sema4C protein, rat Chemical MeSH Browser
Sema4c protein, human Chemical MeSH Browser
Sema4c protein, mouse Chemical MeSH Browser
Sema4d protein, mouse Chemical MeSH Browser
Sema4g protein, mouse Chemical MeSH Browser
Sema5A protein, mouse Chemical MeSH Browser
Sema5c protein, Drosophila Chemical MeSH Browser
Sema6A protein, rat Chemical MeSH Browser
Sema6a protein, mouse Chemical MeSH Browser
Sema6a protein, zebrafish Chemical MeSH Browser
Sema6b protein, mouse Chemical MeSH Browser
Sema6c protein, mouse Chemical MeSH Browser
Sema6c protein, rat Chemical MeSH Browser
Sema6d protein, mouse Chemical MeSH Browser
Sema7a protein, mouse Chemical MeSH Browser
Sema7a protein, rat Chemical MeSH Browser
Semaphorin 3E, chicken Chemical MeSH Browser
sema3d protein, zebrafish Chemical MeSH Browser
semaphorin 1a, Drosophila Chemical MeSH Browser
semaphorin 3A lytic peptide Chemical MeSH Browser
semaphorin 3C protein, mouse Chemical MeSH Browser
semaphorin 3G, human Chemical MeSH Browser
semaphorin 3G, mouse Chemical MeSH Browser
semaphorin 4B, human Chemical MeSH Browser
semaphorin 4B, mouse Chemical MeSH Browser
semaphorin 4E, zebrafish Chemical MeSH Browser
semaphorin 6D, zebrafish Chemical MeSH Browser
semaphorin Z8 Chemical MeSH Browser